DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdlim4 and Pax

DIOPT Version :9

Sequence 1:	NP_062290.2	Gene:	Pdlim4 / 30794	MGIID:	1353470	Length:	330	Species:	Mus musculus
Sequence 2:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	77/369 - (20%)
Similarity:	113/369 - (30%)	Gaps:	128/369 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 HSVTLRGPSPWGFRLVGGRDFSAPLT---------ISRVHAGSKAALAAL--------------- 43
            :||..|.|:       .|.||:...|         :.|..||:...|:.|
  Fly    88 YSVETRSPT-------AGHDFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKIDVPVN 145

Mouse    44 --CPGDLIQAINGEST------------EL-MTHLEA-------QNRIKGCHDHLTLSVSRPENK 86
              .|......:|..:|            || ..|:.|       ::...|.|..:|:..::.|..
  Fly   146 YSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKL 210

Mouse    87 NWPSAP------------DDKAQAH-----RIHIDPESQDCSPATSRRSSVSGISLEDNRSGLGS 134
            ..|..|            |.....|     ::|....||.........:|:|...:.:..:|:|
  Fly   211 TGPDGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIG- 274

Mouse   135 PYGQPPRLPVPHNGSSNEATLPAQMSALHVSPPTSADTARVLPRNRDCRVDLGSEVYRMLREPAE 199
                        |||.     |.|.|:. |...|..|.||  |..       ||:...:.:...|
  Fly   275 ------------NGSH-----PQQHSST-VQHQTVTDYAR--PNK-------GSQQAHLTQTIEE 312

Mouse   200 PTASEPKQSGSFRYLQGMLEAGEGGDRPGSGGPRNLKPAASKLGAPLSGLQGLPE-----CTRCG 259
            .|..|..:......:.|.|:|.                         ...||:..     |..|.
  Fly   313 TTIVEDSREDQLDSMLGNLQAN-------------------------MSRQGVNTVQKGCCNACE 352

Mouse   260 HGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
            ..|||.::.|..|.:|||.|.|:.|...|..|.:|..|...|||
  Fly   353 KPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCE 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdlim4	NP_062290.2	PDZ_signaling	2..80	CDD:238492	23/122 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..153		9/48 (19%)
		DUF4749	150..226	CDD:292558	17/75 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..242		1/22 (5%)
		LIM_RIL	255..307	CDD:188835	20/49 (41%)
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	20/49 (41%)
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810