DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tie1 and htl

DIOPT Version :9

Sequence 1:	XP_001334673.5	Gene:	tie1 / 30746	ZFINID:	ZDB-GENE-990415-55	Length:	1122	Species:	Danio rerio
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	463	Identity:	167/463 - (36%)
Similarity:	245/463 - (52%)	Gaps:	69/463 - (14%)

- Green bases have known domain annotations that are detailed below.

Zfish   712 WSSFVQAQTPGEGLSSFIPTTQQVGRPLAEDHQLLFAVV-GSVAVT----------CVTILLALL 765
            |.:.|::.:.|:..|:   ...:|.|.|   |.|...|. ||:..|          .:.|.:..|
  Fly   269 WYTCVESNSLGQSNST---AYLRVVRSL---HVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTL 327

Zfish   766 ALFY-IRK----SVLKRRRTFTYQ----------------SGSGEETILQF----NSGTLTLTRR 805
            .:|| |||    .|||:|....:|                |||.:..|:..    ...|..|...
  Fly   328 FVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNG 392

Zfish   806 PKPSP-EPLTYPI-LEWE----DIKFEDVIGEGNFGQVIKAMVKKDGIKMSAAIKMLKEFASEND 864
            .:|:| ....:|: ..||    .:.....:|||.||:|:.|.|.    ....|:||:||..:::|
  Fly   393 NEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN----NAIVAVKMVKEGHTDDD 453

Zfish   865 HRDFAGELEVLCKLGQHTNIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVL----ETDPAF 925
            ......|:||:..:|:|.|||||:|.|...|.||:.:||||:|||.|||.|:|..    :.|.:.
  Fly   454 IASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQ 518

Zfish   926 AKEHGTASTLTSQQLLQFAADVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSR---G 987
            ......|..:|.:.|::||..:|.||.||:.::.||||||||||||.|:.|.|||||||:|   .
  Fly   519 PPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQS 583

Zfish   988 EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPY-CGMTCAELYEKLP 1051
            .:.|.|.|.||||::|||.|||....|.:||||||:|:|||||::.|..|| ..|:..|||..|.
  Fly   584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLM 648

Zfish  1052 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRMQEARKAYVNMALFENFTYAGID 1116
            .|.|||:|..|...:|.||||||.....:||||::|...::::.:.::.|:::.:      |.:|
  Fly   649 SGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI------ANLD 707

Zfish  1117 ---ATAEE 1121
               :|::|
  Fly   708 TPPSTSDE 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tie1	XP_001334673.5	EGF_CA	<219..244	CDD:238011
		IG_like	346..431	CDD:214653
		fn3	<461..508	CDD:278470
		fn3	538..616	CDD:278470
		FN3	628..720	CDD:238020	2/7 (29%)
		PKc_like	820..1116	CDD:304357	130/307 (42%)
		Pkinase_Tyr	823..1091	CDD:285015	126/275 (46%)
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653	4/22 (18%)
		PKc_like	404..692	CDD:304357	129/291 (44%)
		STYKc	416..688	CDD:214568	126/275 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810