DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elavl4 and Rbp9

DIOPT Version :9

Sequence 1:	NP_001231529.1	Gene:	elavl4 / 30737	ZFINID:	ZDB-GENE-990415-246	Length:	411	Species:	Danio rerio
Sequence 2:	NP_001259974.1	Gene:	Rbp9 / 33498	FlyBaseID:	FBgn0010263	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	234/452 - (51%)
Similarity:	284/452 - (62%)	Gaps:	71/452 - (15%)

- Green bases have known domain annotations that are detailed below.

Zfish    16 EGSTETQWRQADLPQLQGWAE-----KGLLTQPKMI--ISNMEPQVTNGPNS------------- 60
            ||.|..| :|...|...|.|.     .|....|...  ::|.:.|...|..:
  Fly     3 EGQTAVQ-QQQQQPSGAGGASGVGSTTGSAGGPATANNVTNSQAQTNGGTTATTTAAAGAGSTTN 66

Zfish    61 -----ATANGPSSNSRSCPSPMQTGGSND-----------DSKTNLIVNYLPQNMTQEEFRSLFG 109
                 ||||..:||:.:..:......:|:           |.|||||||||||.|:|:|.||||.
  Fly    67 AAVGQATANNAASNNNNNNNNTNNNNNNNATANNNNNNEPDPKTNLIVNYLPQTMSQDEIRSLFV 131

Zfish   110 SIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDA 174
            |.||:|||||:|||:||||||||||||:..:|||||||.|||||||.||||||.|||||.||:.|
  Fly   132 SFGEVESCKLIRDKVTGQSLGYGFVNYVKQEDAEKAINALNGLRLQNKTIKVSIARPSSESIKGA 196

Zfish   175 NLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGPTGGSRGVGFIRFDKRIEAEEAIKGLN 239
            |||||||||.|||.:||.|||.||:|||||||.|.:||.   |:||||||||:|.||:.|||.||
  Fly   197 NLYVSGLPKNMTQSDLESLFSPYGKIITSRILCDNITGL---SKGVGFIRFDQRFEADRAIKELN 258

Zfish   240 GQKPSGAAEPITVKFANNPSQKTSQALLSQLYQSP-----NRRYP-------------GPLHHQA 286
            |..|..:.||||||||||||...:.......|.:|     .|.:|             ..:|..|
  Fly   259 GTTPKNSTEPITVKFANNPSSNKNSMQPLAAYIAPQNTRGGRAFPANAAAGAAAAAAAAAIHPNA 323

Zfish   287 QRFRLDNLLNMAYGVKRFSPITIDSMTSLVGMNIPGHT--GTGWCIFVYNLSPDSDESVLWQLFG 349
            .|:        :..:.|:||:|.|.:|:  || |.|:|  .:|||||||||:||::|:|||||||
  Fly   324 GRY--------SSVISRYSPLTSDLITN--GM-IQGNTIASSGWCIFVYNLAPDTEENVLWQLFG 377

Zfish   350 PFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKS 411
            |||||.:||||||..:||||||||||||||:||.:||.|||||.||:|||||||||||..::
  Fly   378 PFGAVQSVKVIRDLQSNKCKGFGFVTMTNYEEAVLAIQSLNGYTLGNRVLQVSFKTNKNKQT 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elavl4	NP_001231529.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..89		11/67 (16%)
elavl4	NP_001231529.1	ELAV_HUD_SF	85..410	CDD:273741	214/344 (62%)
Rbp9	NP_001259974.1	ELAV_HUD_SF	107..438	CDD:273741	214/344 (62%)
		RRM1_Hu	109..186	CDD:241094	61/76 (80%)
		RRM2_Hu	196..274	CDD:241096	55/80 (69%)
		RRM3_Hu	355..432	CDD:240823	61/76 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5514
eggNOG	1	0.900	-	-		E1_KOG0145
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40729
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1806
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425303at33208
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	1	1.000	-	-		mtm6531
orthoMCL	1	0.900	-	-		OOG6_103306
Panther	1	1.100	-	-	O	PTHR10352
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.830