DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cntn2 and Cont

DIOPT Version :9

Sequence 1:	NP_571521.1	Gene:	cntn2 / 30726	ZFINID:	ZDB-GENE-990630-12	Length:	1040	Species:	Danio rerio
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1014	Identity:	312/1014 - (30%)
Similarity:	466/1014 - (45%)	Gaps:	82/1014 - (8%)

- Green bases have known domain annotations that are detailed below.

Zfish    33 GPVFEEQPSSLIYPEGMPE--GKVTLGCQARSSPAAVYRW--------RVNGTDISFAEESHYTQ 87
            ||.|.:||:...:......  ..|||.|.|...|...|.|        |:....|....:..||.
  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI 425

Zfish    88 VAGNLVINNPQNGRDGGSYQCLAINRCGTIVSRVANLKFGYLRDFPPESRSPQTVHEGMGTFLAC 152
            ..|||:|..|:...|.|:|.|:|.|:.|.|.|..|:|.||::.:|..: ||.:|.....|..:.|
  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK-RSAETSEMNWGKSIFC 489

Zfish   153 QPPAHYPALSYRWFINEFPNFIQPEAGRWFVSQVTGNLYLANARANDTGNYFCFTTINMDVSTKS 217
            .||.|||.:.|.|..:.||||:: |..|.|||: .|.||.:.....|..||.|  |:...||...
  Fly   490 DPPQHYPDVRYYWARDYFPNFVE-EDQRVFVSR-DGALYFSFIETVDRANYSC--TVQTLVSDTG 550

Zfish   218 IFSKAVQLTVHPDASPR-----KTAPNIRVRFPAETYALSGQTAQLECFAYRNPIPKIRWRKVDG 277
            .......|.|.|:::.:     .|.|.:   ||....|  |...:|||.|:..|||...|.:...
  Fly   551 RNGPFFPLRVTPNSNYQALIFANTFPKV---FPEAPVA--GDEIRLECMAFGYPIPSYNWTRQGL 610

Zfish   278 ILPPKVGTSVDGPILIIPELNFDDEGMYECEVYNSEGRETHQGRVSVQAQPDWLQVMSDSEVEIS 342
            .|.....|...|.:|||.....:|.|.|.|.:.|..........:::|.:|.:...:.|...:.:
  Fly   611 PLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYN 675

Zfish   343 SELQWSCAAAGKPRPTIRWLRNGHAL----ITQDRVEVNNGRLKIANLALE-DSGMYQCVAENKH 402
            |::.:.|.|...|.....|.:|...|    |.:||..:.:..|.|..|..: |..||||.|:|:.
  Fly   676 SDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQL 740

Zfish   403 STIYSNAELRVQVQAPDFRLNPVRKLVPAARGGQVKMECKPRAAPKPTLFWSRGTELLTNSTRIT 467
            .|.:|:|:|||....|.|:.:|:...|.|...|...:.|.|.|||:|...|.:..:::.:.....
  Fly   741 KTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRR 805

Zfish   468 VTPDGILWIYNISRADEGKYTCFAENYLGKANSTGHLSVRDATKITLAPSNADINQGENAT-LQC 531
            :.|.|.|.|...||.|||.|||.|.|..|...|...:.|....:....|....:::..:.. |.|
  Fly   806 ILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHC 870

Zfish   532 HASHDPTMDLTFTWSLNGVPLDLEEPNGHYRRMEGKETI----GDLVIVNGQLSHAGTYTCTAQT 592
            .|:.|..:|:.:.|..||..|    .|.|    :|...|    ..|.:.|..:..||.|.|..::
  Fly   871 EAAFDELLDIAYVWKHNGEVL----KNNH----DGTGRIIVDWNRLTVHNTSMRDAGDYECVVKS 927

Zfish   593 VVDSAMASAKLVVRGPPGPPGGLVVTSVNDTSVELRWSRGYDNHSPIGKYVILGRSSQTHDWKRM 657
            .|:...:...:.:.|.||.|||:.|..::.|...:.|..|..|...|..|.||||::....|..:
  Fly   928 AVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNV 992

Zfish   658 RTDPANIE----GNAESARVIDLRPWMDYEFQVIASNILGSGEPSMPSPRAQTKEAAPTVAPSGL 718
            .|.....|    .:.:.|.|::|.||..|||.|.|.|.||.|.||.|||...|.|..|.:||..:
  Fly   993 STHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNV 1057

Zfish   719 GGGGGNRNELIITWTPMAREYQNGDSFGYILAFRKQGIPTWTV----------VKVPNVESSRYV 773
            |||||...:|.|||.|:..:.|:.....|.:.::.:|...|..          |.|.|:..:.|
  Fly  1058 GGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNY- 1121

Zfish   774 YSNDSLTAYCPFEVRIKAYNKKGEGPFSQIAVVHSAEEEPTVSPRWINATALTAFEIQVSWEPI- 837
                    |..:||:::|.|..|:||.|:|||:||||:.|.|:|:...|.|..:....|:|:||
  Fly  1122 --------YTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPID 1178

Zfish   838 -QHLNINGVLRGYEIRYWRQHEREAAADRVRTAGLENTARVTGLRPNTLYHITVLAYNSAGTGPA 901
             ...||.|.|.|:.::||:...:|..:....:....|.|.:.||:|:|.|.:.|:|||:||.||.
  Fly  1179 MSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPE 1243

Zfish   902 SPRTTVITKKPPPNRPPGNVS-WKVDGSWVTVRWDHVKSMDNESAVLGYKVLYKHEGQSALKVLE 965
            |.|....|.:..|.:||.:|. :.::.|.|.|.|.:|....:|..|.||||......|:   ::.
  Fly  1244 SERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQN---MIT 1305

Zfish   966 KSKTSVKLPLPKDNGYV---------VLEIRSWGDGGDG 995
            .:.|.|.:. .|...|:         .:.:.::.:||||
  Fly  1306 ANNTIVPIG-QKLESYINNLTPGKSYNMRVLAYSNGGDG 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cntn2	NP_571521.1	Ig1_Contactin-2	33..126	CDD:143258	33/102 (32%)
		I-set	34..125	CDD:254352	31/100 (31%)
		Ig	128..225	CDD:299845	32/96 (33%)
		IG_like	138..227	CDD:214653	31/88 (35%)
		Ig	238..325	CDD:299845	24/86 (28%)
		IG_like	245..324	CDD:214653	22/78 (28%)
		Ig	329..413	CDD:299845	25/88 (28%)
		IG_like	335..413	CDD:214653	25/82 (30%)
		IG_like	429..506	CDD:214653	26/76 (34%)
		Ig5_Contactin_like	434..506	CDD:143170	24/71 (34%)
		I-set	511..605	CDD:254352	21/98 (21%)
		Ig6_Contactin-2	525..606	CDD:143262	20/85 (24%)
		FN3	615..702	CDD:238020	31/90 (34%)
		FN3	714..806	CDD:238020	31/101 (31%)
		FN3	817..909	CDD:238020	32/93 (34%)
		FN3	917..1002	CDD:238020	23/89 (26%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	31/98 (32%)
		I-set	362..462	CDD:254352	31/99 (31%)
		Ig	466..559	CDD:299845	32/97 (33%)
		IG_like	584..657	CDD:214653	21/74 (28%)
		IGc2	586..645	CDD:197706	19/58 (33%)
		Ig	667..751	CDD:299845	25/83 (30%)
		IG_like	676..751	CDD:214653	24/74 (32%)
		IG_like	765..844	CDD:214653	26/78 (33%)
		Ig	773..844	CDD:299845	24/70 (34%)
		I-set	851..940	CDD:254352	21/96 (22%)
		Ig	866..944	CDD:299845	21/85 (25%)
		FN3	944..1043	CDD:238020	38/98 (39%)
		FN3	1053..1146	CDD:238020	31/101 (31%)
		fn3	1156..1244	CDD:278470	30/87 (34%)
		fn3	1259..1346	CDD:278470	23/89 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9761
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1476
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm24534
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.740