DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chrna1 and nAChRbeta1

DIOPT Version :9

Sequence 1:	NP_571520.1	Gene:	chrna1 / 30725	ZFINID:	ZDB-GENE-980526-137	Length:	456	Species:	Danio rerio
Sequence 2:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	193/498 - (38%)
Similarity:	285/498 - (57%)	Gaps:	70/498 - (14%)

- Green bases have known domain annotations that are detailed below.

Zfish    21 SEDETRLVKTLFTGYNKVVRPVSHFKDPVVVTVGLQLIQLISVDEVNQIVTSNVRLKQQWKDVHL 85
            ||||.|||:.||.||||::|||.:....|.|..||..:|||:|:|.|||:.|||.|:..|.|..|
  Fly    25 SEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQL 89

Zfish    86 QWNPDDYGGIRKIRIPSTDLWKPDLVLYNNADGDFAIVHETKVLLEHTGMITWTPPAIFKSYCEI 150
            ||:..|||||..:|:|...:||||:||:|||||::.:.:::.||:..||.:.|.||||::|.|.|
  Fly    90 QWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTI 154

Zfish   151 VVLHFPFDLQNCSMKLGTWTYDG---NLVIINPDSDRPDLSNFMESGEWVMKDYRSWKHWVYYAC 212
            .|.:||||.|.|.||.|:||::|   :|.:.| :.:..|||::.:||.|.:.:..::.: ||...
  Fly   155 DVTYFPFDQQTCIMKFGSWTFNGDQVSLALYN-NKNFVDLSDYWKSGTWDIIEVPAYLN-VYEGD 217

Zfish   213 CPDTPYLDITYHFLLLRLPLYFIVNVIIPCMLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFL 277
            .......|||::.::.|..|::.||:|:|.:|.|||..||||||.::|||:||.||:||||.|||
  Fly   218 SNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFL 282

Zfish   278 LVIVELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVINTHHRSPSTHIMPAWVRKIFIDTIPN 342
            |::.:::|.||..:|||.||:|||.|....||::|||:||.:.|.|.||.||.::|.||:..:|.
  Fly   283 LLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPA 347

Zfish   343 MMFFSTMKRPSQERQEKRL----------------FPADF--DISDISGKPMPASV----TYHSP 385
            .:|   ||||.:.|....:                .||:.  .||.|.||.....|    ..|.|
  Fly   348 FLF---MKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHP 409

Zfish   386 -----------------------------ITKNPDVRSAIEGVKYIADTMKSDEESNNAAEEWKF 421
                                         |..:|:...|.|.|::||:.:::::......|:||:
  Fly   410 NCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKY 474

Zfish   422 VAMVLDHILLCVFMAVCIIGTLGVF-----------AGRLIEL 453
            ||||:|.:.|.:|..|...||:|:.           ..|:||:
  Fly   475 VAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEI 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chrna1	NP_571520.1	LIC	21..447	CDD:273305	190/490 (39%)
		Neur_chan_LBD	24..231	CDD:280998	91/209 (44%)
		Neur_chan_memb	238..446	CDD:280999	93/258 (36%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	190/479 (40%)
		Neur_chan_LBD	28..236	CDD:280998	91/209 (44%)
		Neur_chan_memb	243..498	CDD:280999	92/257 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.880