DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HELLS and SPAC144.05

DIOPT Version :9

Sequence 1:	NP_001275996.1	Gene:	HELLS / 3070	HGNCID:	4861	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001342916.1	Gene:	SPAC144.05 / 2542902	PomBaseID:	SPAC144.05	Length:	1375	Species:	Schizosaccharomyces pombe

Alignment Length:	1370	Identity:	242/1370 - (17%)
Similarity:	392/1370 - (28%)	Gaps:	666/1370 - (48%)

- Green bases have known domain annotations that are detailed below.

Human    45 ERKMLEKARMSWDRESTEIRYRRLQHLLEK--SNIYSKFLLTKMEQQQLEEQ---KKKEKLERKK 104
            :|:.:||       |::.:..|  .:|||.  :|.|..|    ..|.:|::|   ..:::|.|.|
pombe     5 KRRKIEK-------EASLLNER--NNLLESDFANCYRAF----QHQLKLDQQIWRGPEDELNRLK 56

Human   105 ESL---------------------KVKKGKN-----SIDASEE------KPV----------MRK 127
            .::                     |:...||     |:|.:::      .|:          .|.
pombe    57 STIYPVVFWVDGSEKLHAYSFTQRKISLAKNLIPLFSVDLNKDTYSALKAPLKIWSKLWEDNRRL 121

Human   128 KRGREDESYNISEVMSKEEILS---------VAKKNKKENEDENSSSTNLCVEDLQKNKDSNSII 183
            |:..:..||  ..|...|.|||         :|.::...:...:||.|.|.......::|.....
pombe   122 KKIIKYTSY--VTVKGSELILSFGISILDSFLAPQDAILSSGSSSSYTALLDYTFLPSEDEEYSC 184

Human   184 KDRLSETVRQNTKFFFDPVRK---------------CNGQPVPFQ-----------QPKHFTGGV 222
            .|       .||..|:|..||               .:.:.:|||           :.|..|...
pombe   185 LD-------INTALFYDCARKLAKSLRFANVSRDPRLSSELLPFQMRVLEWMKRREEEKFLTSND 242

Human   223 M--RWYQVEGMEWLRMLWENGI--------------------NGILADEMGLGKTVQCIATIALM 265
            :  .||..:.:...||::.|.:                    .||||||||:|||::   .:.|:
pombe   243 LPPLWYHCKSLFDDRMVYVNHVYGYMTFSKEKTYLLASGDIRGGILADEMGMGKTLE---VLGLV 304

Human   266 IQRGVP--------------------GPFLVCGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQ 310
            :...:|                    ...|:..|.:.|..|::|.....|.:....|.|.::.
pombe   305 LHHQLPISLTDTCTFDQVVGKNVKYSKATLIITPSTILDQWLSEIDLHVPSLKVFHYQGIRKS-- 367

Human   311 KLVRNIYKRKGTLQIHPVVITS-----FEIAMRDRNA--LQH--------------CYWKYLIVD 354
                |..|.........:|:||     ||:...:.::  |:|              |:|: :.||
pombe   368 ----NGLKSAKIFLDCDIVVTSYSDLRFELLYTESHSRTLRHEKRHVSPKSPLIDVCWWR-ICVD 427

Human   355 EGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITS 419
            |...::..:..:.:.:.|....|...::|||:::.:.:|:.|| |||......|...::|..|..
pombe   428 EAQMVETSQSNVAQMIYRIPRVNCWTVSGTPVRSEVDDLFGLL-FLLRYSPMYLYKKQAWMQIIE 491

Human   420 LSETAE------DIIAKEREQNV---LHMLHQERI---PRMYVSEFT------------------ 454
            .....|      .::.:..:|:|   |.:..|.||   .|:.|.|.|
pombe   492 KKRVREFCDLFGSLVCRHSKQDVEEELKLPPQHRICMTTRLSVVEETNYQDLLSEAAKSLHFFKD 556

Human   455 ------DE-------------------GF-----FEG--------------------------KL 463
                  ||                   ||     |.|                          ||
pombe   557 RNLDLCDEESMRRWLVRLRQACCHPQVGFGNKSAFGGGPMKSINDVLVFMLEQTNSTFSSLNRKL 621

Human   464 PSRK----DLYD----------------------IRPYENT------------------------ 478
            .|.|    .:||                      ::..||.
pombe   622 YSDKIIVGQIYDHIKDYNKALAIWSEVRIPVELAVKELENVIYNSKYEDHGKNLPINYFGLDHFI 686

Human   479 -----YLL------------------KLHTNFEILTPFLLRRLKSDVALE------------VPP 508
                 |:|                  |....|.:|...|.|::.|||.::            :|.
pombe   687 HLRVWYVLLHKIYFFIASAYFSLKNEKFENEFYLLAQDLRRKIMSDVIIKTSKHLEEFSEKFIPK 751

Human   509 K-----------------------------------REVVV------------------------ 514
            |                                   :||::
pombe   752 KLVKIPRLQKSYAKGLITGHGIIEDYNRLYKELNDQKEVLIKFRDRLIHLMKLPLLDQESDPTGD 816

Human   515 --YAPLSKKQEIFY------------TAIVNRTIANMFGSSEKET-------------------- 545
              ...|:.:.||.|            .|.|:.|| |.|.|.|.|.
pombe   817 EYEESLNAQSEISYCIDVYRQMLSDRVAAVSGTI-NTFVSHETELEKYKLIESIKKSEKSLDKQA 880

Human   546 ----------IELSPTGRPKR------------------------RTRKSI-NYSKIDDFPNE-- 573
                      .|.....|||.                        .|.|:: .|.:||....|
pombe   881 EERDKKYLLYFEEREEARPKADQYGSLINIVSRLLDASNRSTSSFETSKNMEEYERIDAMAKEQS 945

Human   574 ----------------------------------------------------------------- 573

pombe   946 RICQKLEKELSIIQLTYNSRIEYYKQLQEISDSLMPPPVSNISLNNYVKDDEKKQKFLNSVIIKA 1010

Human   574 ---LEKLISQIQPEVDR--------ERAVVEVNIP--------VESE------------------ 601
               |||.||:.|.|..:        .:.:.|:|||        :|.|
pombe  1011 SVILEKEISEKQDEASQTTNVAELVNQKISEMNIPGHIHLLRELEEEKSNTQRKIAHFESRRRYL 1075

Human   602 ------VNLKLQN--IMMLLR----------------------------KC--C------NHPYL 622
                  :.||.::  |.::.|                            .|  |      |:.|.
pombe  1076 TNLYEHIVLKAESHQICIICRDIIKQGFITTCGHLYCSFCLEAWLKHSSSCPMCKTKLNKNNAYY 1140

Human   623 IEYPIDPVT-QEF-----KIDEEL----------VTN-------SGKFLILDRMLPELKKRGH-- 662
            |....|..: |||     |.||.|          ::|       ..|...:.:.|..||   |
pombe  1141 IGESRDIYSRQEFVTGFNKRDERLEILDDEAYRQISNMELKESFGSKIDTISKHLLYLK---HNE 1202

Human   663 ---KVLLFSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSEREKN--MHSFNTDPEVFIFLVSTRA 722
               ||::|||...:||:|..........|.|.||      :.||  :..|..:..:.:..:..|:
pombe  1203 LYPKVVVFSQWLDVLDVLHKSFEANGIVFIRFDG------KSKNTCLKRFKEERSLQVLTLHARS 1261

Human   723 GGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAK-R 786
            ...|:.||.|..|.:.:...|...::||..|.||||||:|..||..:..:|::..|:..:..| .
pombe  1262 QSSGLTLTNATHVFMCEPLLNSGIEMQAISRVHRIGQTRPTFVYYYIVEDTVEGHILNLSLTKHE 1326

Human   787 KLEKL 791
            :|:||
pombe  1327 QLDKL 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HELLS	NP_001275996.1	SNF2_N	221..>869	CDD:331286	192/1112 (17%)
SPAC144.05	NP_001342916.1	SNF2_N	284..582	CDD:331286	62/308 (20%)
		SMC_N	<877..>1087	CDD:330553	25/209 (12%)
		RING-HC_COP1	1088..1133	CDD:319418	4/44 (9%)
		RAD18	1092..>1192	CDD:333230	16/99 (16%)
		RING-HC finger (C3HC4-type)	1092..1129	CDD:319418	2/36 (6%)
		HepA	<1198..1331	CDD:223627	41/141 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910