Protein Alignment HELLS and rhp26

DIOPT Version :9

• Sequence 1: NP_001275996.1
• Gene: HELLS / 3070
• HGNCID: 4861
• Length: 884
• Species: Homo sapiens
• Sequence 2: NP_588091.1
• Gene: rhp26 / 2539473
• PomBaseID: SPCP25A2.02c
• Length: 973
• Species: Schizosaccharomyces pombe
• Alignment Length: 1084
• Identity: 254/1084 - (23%)
• Similarity: 402/1084 - (37%)
• Gaps: 411/1084 - (37%)

Human    19 EQLDTAVITPAMLEEEEQLEAAGLERERKMLEKARMSWDRESTEIRYRRLQHLLE--------KS 75
            |.|:..|...|    .|.:.....|.|:|.|:|.|.  :..|.:.:.|||...::        |.
pombe    18 ENLERDVTNTA----SEYIAHESREIEKKRLQKVRK--EISSVKEKIRRLDERIDSRLTKISVKE 76

Human    76 NI---YSKFLLTKMEQQQLEEQKKK------------------EKLERKKESLKVKKGK------ 113
            |.   .|||..|....|..|...|:                  |:|||::   .::.||
pombe    77 NFRKQLSKFRDTLQSLQSDENDIKRRLNNEDSANAPGIGAFSTEELERQE---LIRTGKVTPFRN 138

Human   114 -----NSIDASEEKPVMRK---------------------------KRGREDESYNISEVMSK-- 144
                 ..:|..:|..:...                           .|..:||...:..|..|
pombe   139 LSGLQKEVDFDDESSIREAVIKSEGTYYETAPHLSSEPSNIDHGIIPRDEKDEYVTVDAVTEKVV 203

Human   145 ------------EEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKF 197
                        .:.|:....|:||..|:.|:|.|        |||....
pombe   204 TAAIDDGDDLVYRQRLNAWCANRKELRDQASASEN--------NKDRGEF--------------- 245

Human   198 FFDPVRKCNGQ-----PVPFQQPKHFTGG----------VMRWYQVEGMEWLRMLWENGINGILA 247
                    .|:     |.|.::.:.|.||          :.| |||..::||..|:.....||:.
pombe   246 --------EGKDEWLLPHPSKKGQTFEGGFTIPGDIRPHLFR-YQVTCVQWLWELYCQEAGGIIG 301

Human   248 DEMGLGKTVQCIATIALMIQRG-VPGPFLVCGPLSTLPNWMAEFKRFTPDIPTMLYHGT------ 305
            ||||||||:|.::.::.:...| ...|.|:..|.:.:..|:.||..:...:..::.|.|
pombe   302 DEMGLGKTIQIVSFLSSLHHSGKFQKPALIVCPATLMKQWVNEFHTWWAPLRVVVLHATGSGQRA 366

Human   306 -QEERQ-------------------------------KLVRNIYKRKGTLQIHPVVITSFE---- 334
             :|:||                               .||.:::.|.     | ::||::.
pombe   367 SREKRQYESDASESEAEESKTSIKLRGASSSFHRYAKNLVESVFTRG-----H-ILITTYAGLRI 425

Human   335 ----IAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWS 395
                |..|:        |.|.::||||:|:|....:....|:....|:::|:|||:||||:|||:
pombe   426 YGDLILPRE--------WGYCVLDEGHKIRNPDSEISISCKQIRTVNRIILSGTPIQNNLTELWN 482

Human   396 LLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQERIPRMYVSEFTDEGFFE 460
            |.:|:.|.....|..|::.|
pombe   483 LFDFVFPGRLGTLPVFQNQF--------------------------------------------- 502

Human   461 GKLPSRKDLYDIRPYENTYLLKLHTNF-------EILTPFLLRRLKSDVALEVPPKREVVVYAPL 518
             .||     .:|..|.|...:::.|.:       ::::|:||||:|.|||.::|.|.|.|::..|
pombe   503 -ALP-----INIGGYANASNVQVQTAYKCACMLRDLISPYLLRRMKLDVAADLPKKSEQVLFCKL 561

Human   519 SKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDF--PNELEKLISQI 581
            :..|...|                                         .||  .::::|::
pombe   562 TPLQRKAY-----------------------------------------QDFLQGSDMQKIL--- 582

Human   582 QPEVDRERAVVEVNIPVESEVNLKLQNI--MMLLRKCCNHPYLIEYPIDPVTQEFKIDEELVT-- 642
                                 |.|.|.:  :.:|||.||||       |.||:|:.:.:|...
pombe   583 ---------------------NGKRQMLYGIDILRKICNHP-------DLVTREYLLHKEDYNYG 619

Human   643 ---NSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDIL-MDYCHLRDFNFSRLDGSMSYSEREKN 703
               .|||..::..:|...||:||:.|||||...||||| :....|.|.::.|:|||.|.:.|:..
pombe   620 DPEKSGKLKVIRALLTLWKKQGHRTLLFSQTRQMLDILEIGLKDLPDVHYCRMDGSTSIALRQDL 684

Human   704 MHSFNTDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRL 768
            :.:||.:....:||::||.||||:|||.||.||::|.||||.:|.||::|..|:||.|.||||||
pombe   685 VDNFNKNEYFDVFLLTTRVGGLGVNLTGADRVILFDPDWNPSTDAQARERAWRLGQKKDVVVYRL 749

Human   769 VTANTIDQKIVERAAAKRKLEKLII---------------------------------------- 793
            :||.||::||..|...|:.|...|:
pombe   750 MTAGTIEEKIYHRQIFKQFLTNKILKDPKQRRFFKMTDLHDLFTLGDNKTEGTETGSMFLGSERV 814

Human   794 -----------------------HKNHFKGGQSGLNLSKNFLDPKELMELLKSRDYEREIKGSRE 835
                                   ||.|.||.:  :|.||.|    |.|.:.....|    |..:|
pombe   815 LRKDNSSRNGNEAEDIPARDRKKHKIHDKGKK--VNSSKVF----EKMGIASMEKY----KPPQE 869

Human   836 KVISDKDLELLLDRSDLIDQMNASGPIKEKMGIFKILENSEDSS 879
            ..::..:.:..|....::|.:.||..|:..:....|:|.|:..|
pombe   870 SNVTKTNSDSTLGDDSVLDDIFASAGIQSTLKHDDIMEASQTES 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HELLS	NP_001275996.1	SNF2_N	221..>869	CDD:331286	197/784 (25%)
rhp26	NP_588091.1	HepA	36..795	CDD:223627	226/932 (24%)
		DEXDc	297..472	CDD:238005	43/188 (23%)
		HELICc	617..747	CDD:238034	58/129 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910