DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HELLS and Hells

DIOPT Version :9

Sequence 1:	NP_001275996.1	Gene:	HELLS / 3070	HGNCID:	4861	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_032260.2	Gene:	Hells / 15201	MGIID:	106209	Length:	821	Species:	Mus musculus

Alignment Length:	868	Identity:	750/868 - (86%)
Similarity:	798/868 - (91%)	Gaps:	47/868 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    17 MVEQLDTAVITPAMLEEEEQLEAAGLERERKMLEKARMSWDRESTEIRYRRLQHLLEKSNIYSKF 81
            |.||.:.||||||||||||||||||||:||||||:|:.|||||||||||||||||||||||||||
Mouse     1 MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKF 65

Human    82 LLTKMEQQQLEEQKKKEKLERKKESLKVKKGKNSIDASEEKPVMRKKRGREDESYNISEVMSKEE 146
            ||||||||||||||||||||:||.|||:.:||:.:|.:.|||||:||||||||||||||||||||
Mouse    66 LLTKMEQQQLEEQKKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEE 130

Human   147 ILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQPVP 211
            |||||||: |:||||:||:|:|||||:||||||||:||||||:|||||:||||||||||||||||
Mouse   131 ILSVAKKH-KDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVP 194

Human   212 FQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLV 276
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   195 FQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLV 259

Human   277 CGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRN 341
            |||||||||||||||||||:|||:|||||:|:|:|||:||:||:|||||||||:|||||||||:|
Mouse   260 CGPLSTLPNWMAEFKRFTPEIPTLLYHGTREDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQN 324

Human   342 ALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFD 406
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   325 ALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFD 389

Human   407 DLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQERIPRMYVSEFTDEGFFEGKLPSRKDLYD 471
            ||||||||||||||||||||||||||||||||||||
Mouse   390 DLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQ----------------------------- 425

Human   472 IRPYENTYLLKLHTNFEILTPFLLRRLKSDVALEVPPKREVVVYAPLSKKQEIFYTAIVNRTIAN 536
                             ||||||||||||||||||||||||||||||..||||||||||||||||
Mouse   426 -----------------ILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIAN 473

Human   537 MFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEKLISQIQPEVDRERAVVEVNIPVESE 601
            ||||.||||:|||||||||||:|||||||::|.||:|||||||||||||:|||.|||.|||:|||
Mouse   474 MFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVNRERTVVEGNIPIESE 538

Human   602 VNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLL 666
            |||||:||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||:
Mouse   539 VNLKLRNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLV 603

Human   667 FSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSEREKNMHSFNTDPEVFIFLVSTRAGGLGINLTA 731
            ||||||||||||||||||:|.||||||||||||||||::||||||:||:||||||||||||||||
Mouse   604 FSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSEREKNIYSFNTDPDVFLFLVSTRAGGLGINLTA 668

Human   732 ADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKN 796
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   669 ADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKN 733

Human   797 HFKGGQSGLNLSKNFLDPKELMELLKSRDYEREIKGSREKVISDKDLELLLDRSDLIDQMNASGP 861
            |||||||||:.||||||.|||||||||||||||:||||||||||:|||||||||||||||.||.|
Mouse   734 HFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLELLLDRSDLIDQMKASRP 798

Human   862 IKEKMGIFKILENSEDSSPECLF 884
            ||.|.|||||||||||||.||||
Mouse   799 IKGKTGIFKILENSEDSSAECLF 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HELLS	NP_001275996.1	SNF2_N	221..>869	CDD:331286	560/647 (87%)
Hells	NP_032260.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..120		29/41 (71%)
		DEXHc_HELLS_SMARCA6	203..436	CDD:350767	222/278 (80%)
		PLN03142	204..>781	CDD:215601	539/622 (87%)
		helicase domain I	226..238		11/11 (100%)
		helicase domain Ia	258..266		7/7 (100%)
		helicase domain II	334..341		6/6 (100%)
		helicase domain III	363..370		6/6 (100%)
		helicase domain IV	429..439		9/9 (100%)
		helicase domain IVa	547..559		11/11 (100%)
		'helicase domain IVb	602..609		5/6 (83%)
		helicase domain V	655..668		12/12 (100%)
		helicase domain VI	686..693		6/6 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83953612
Domainoid	1	1.000	648	1.000	Domainoid score	I4420
eggNOG	1	0.900	-	-		E2759_KOG0385
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H50037
Inparanoid	1	1.050	1510	1.000	Inparanoid score	I2974
Isobase	1	0.950	-	0	Normalized mean entropy	S1262
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG59939
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		oto114634
orthoMCL	1	0.900	-	-		OOG6_104380
Panther	1	1.100	-	-	LDO	PTHR47161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.220