Protein Alignment HDLBP and Dp1

DIOPT Version :10

• Sequence 1: NP_005327.1
• Gene: HDLBP / 3069
• HGNCID: 4857
• Length: 1268
• Species: Homo sapiens
• Sequence 2: NP_523781.2
• Gene: Dp1 / 37116
• FlyBaseID: FBgn0027835
• Length: 1301
• Species: Drosophila melanogaster
• Alignment Length: 1323
• Identity: 614/1323 - (46%)
• Similarity: 884/1323 - (66%)
• Gaps: 79/1323 - (5%)

Human     1 MSSVAVLTQESFA----EHRSGLVPQQIKVATLNSEEESDP-----PT---------------YK 41
            |.:.||:.:.:.|    :....|:..|.:||  |.::.|.|     ||               |.
  Fly     1 MQAAAVMEETNNATTIEQQPIALINGQEQVA--NEQQPSSPTSVATPTSTTSGGTGNATPAFSYD 63

Human    42 DAFPPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLE 106
            |.||.||...    |||..:||.|:.:..:.:|..|.:.|||.:|||..:..:|||||..:||.:
  Fly    64 DLFPALPANT----SAQSQSGASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEGESKRICQQ 124

Human   107 IMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGE 171
            |.:.|||.:|:...|:|.|:.::.||...::.||:.|:....||||..|.:|:||.|.::||.|:
  Fly   125 ITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGKGGQ 189

Human   172 KLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPF 236
            :|:::|..|||:|.||...|.|..|.|.||||||.:|..|:..:||||.|::.:|:.|.|.:|||
  Fly   190 RLREIERVTATRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQYKKSSDRITVPKVYHPF 254

Human   237 IAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVE 301
            |.|||:..:.::.:|||.|||:||..|.:.|||.:|||:.:|.|.|:::.||::.:||.:|::||
  Fly   255 IVGPYSENLNKLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVSVE 319

Human   302 VKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTV 366
            |.|.:|:|||||||:::.|||:.||||||:||:||.|||:.|||....||.|||.||.|:||...
  Fly   320 VAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSETITLRGPQVALGNALTVVYQKSNSVKS 384

Human   367 SSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDL 431
            ..:.|..|:|:::||:||.|:.::.:..|.|::...  ||||.|||..|:|:.|...:..::|:.
  Fly   385 VEINAAHWIHKYVIGRKGANMKQLEEDCPNVNVNCL--EDKIKLEGDPENVDRAVAYLSEIIKNY 447

Human   432 INRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRE 496
            .....:..:.::..:::|:|||:|||:||:||:.||::.| .:.|..|.|||||..:||:||:.|
  Fly   448 EENFTFEVMTVNPSYYKHIIGKAGANVNRLKDELKVNINI-EEREGQNNIRIEGPKEGVRQAQLE 511

Human   497 LLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKN 561
            |.|...::|||::||:||::|.||:|||.|||:|||::|::.:|.|..|.|.:.:|||:|||||.
  Fly   512 LQEKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRGPKE 576

Human   562 EVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSET 626
            :|:||.|.:.|:|.::.|:|:.|.|||||||||.:||||||||||||:|:.||||||||...:|.
  Fly   577 DVDKCHKDLLKLVKEIQESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTNEV 641

Human   627 IIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFP 691
            |:||||:.|...|:.||..||.:|::|...||.||.|.:||:|||.|:||.|||||||||.|.||
  Fly   642 IVITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGGVSIKFP 706

Human   692 VEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDS 756
            ...|.||.|.||||..||||||.|||.||.|:|..|||.::|||.::|||||||.|..|||:||:
  Fly   707 NSDSKSDKVTIRGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKIRDA 771

Human   757 TGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQ 821
            ||||:|||:.||.|:::|||||||::|::|:::|||:|:..|.|.|..:.||||||:|||.:||.
  Fly   772 TGARIIFPSNEDTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKRGF 836

Human   822 VLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHR 886
            :|..|:||.||||:||||.|..|||||:||||||:|||::||:||:.|||||.|:|..|||:.||
  Fly   837 ILHRISEECGGVMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHR 901

Human   887 SVMGPKGSRIQQITRDFSVQIKFPDREENAVHSTEPV-------VQENGDEAGEGREA-----KD 939
            ::||.:|.::||:|.:|.||||||||:     :||||       ..|||.| .||:|.     |:
  Fly   902 TIMGARGFKVQQVTFEFDVQIKFPDRD-----ATEPVEGLTNGGSGENGGE-NEGQEGEQEVEKE 960

Human   940 CDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEV 1004
            .:....|:||:|.|:||.|||||||:||..|:|:..|:.|||||||.:||.:|:.:|:.|.:.:|
  Fly   961 AEQEPVRQCDVIRITGRIEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGANVRQFMSKHDV 1025

Human  1005 NIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIG 1069
            ::.:|..||:||:|.:.|..|.:..|:..|::.:::.:|::.||.||||.|.|.||.::|.|:||
  Fly  1026 HVELPPSELKSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIG 1090

Human  1070 RKGAVITQIRLEHDVNIQFPDKDDGNQPQDQ-ITITGYEKNTEAARDAILRIVGELEQMVSEDVP 1133
            |.||||.::|.:|||.|..|.:|   :|.|: |:||||:.|.||||||||.|||:.|.:..|.:.
  Fly  1091 RHGAVINKLRADHDVIISLPKRD---EPNDRIISITGYQANAEAARDAILEIVGDPETLHREVIE 1152

Human  1134 LDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYL 1198
            :|.|:|..:||.|.:.||||:::.||:|:| .:...:||.:.::|..|:||...:.:..:.|:|.
  Fly  1153 IDKRIHPHLIGQRRRTIRKIIEDNKVNIKF-SADDDNPNSIFISGKIEDVENVKELLFGMAEDYE 1216

Human  1199 ADVVDSEALQVYMKPP-----------AHEEAKAPSRGFVVRDAPWTASSSEK---APDMSSSEE 1249
            .|.:|:.|:    .||           ..:.|.|...|||::||||......|   ||:..|.|:
  Fly  1217 RDYLDNVAI----APPTIGAFLTGQGSGSDAAGASENGFVIKDAPWEKQKQAKNLTAPNTQSQED 1277

Human  1250 FPSF---GAQVA--PKTLPWGPK 1267
            ||.|   ||.||  |.|..||||
  Fly  1278 FPHFAAGGAPVASTPITSVWGPK 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDLBP	NP_005327.1	KH-I_Vigilin_rpt1	77..144	CDD:411833	26/66 (39%)
		KH-I_Vigilin_rpt2	147..221	CDD:411834	36/73 (49%)
		KH-I_Vigilin_rpt3	224..283	CDD:411835	27/58 (47%)
		KH-I_Vigilin_rpt4	297..358	CDD:411836	37/60 (62%)
		KH-I_Vigilin_rpt5	364..433	CDD:411837	21/68 (31%)
		KH-I_Vigilin_rpt6	435..502	CDD:411804	28/66 (42%)
		KH-I_Vigilin_rpt7	507..573	CDD:411838	34/65 (52%)
		KH-I_Vigilin_rpt8	583..644	CDD:411839	40/60 (67%)
		KH-I_Vigilin_rpt9	653..722	CDD:411840	45/68 (66%)
		KH-I_Vigilin_rpt10	726..791	CDD:411841	38/64 (59%)
		KH-I_Vigilin_rpt11	802..867	CDD:411842	42/64 (66%)
		KH-I_Vigilin_rpt12	875..970	CDD:411843	50/106 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..944		12/41 (29%)
		KH-I_Vigilin_rpt13	972..1049	CDD:411844	27/76 (36%)
		KH-I_Vigilin_rpt14	1053..1126	CDD:411845	40/73 (55%)
		KH-I_Vigilin_rpt15	1128..1196	CDD:411846	21/67 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1233..1268		19/43 (44%)
Dp1	NP_523781.2	KH-I_Vigilin_rpt1	95..162	CDD:411833	26/66 (39%)
		KH-I_Vigilin_rpt2	165..239	CDD:411834	36/73 (49%)
		KH-I_Vigilin_rpt3	243..>290	CDD:411835	22/46 (48%)
		KH-I_Vigilin_rpt4	315..376	CDD:411836	37/60 (62%)
		KH-I_Vigilin_rpt5	382..449	CDD:411837	21/68 (31%)
		KH-I_Vigilin_rpt6	451..517	CDD:411804	28/66 (42%)
		KH-I_Vigilin_rpt7	522..588	CDD:411838	34/65 (52%)
		KH-I_Vigilin_rpt8	599..659	CDD:411839	40/59 (68%)
		KH-I_Vigilin_rpt9	668..737	CDD:411840	45/68 (66%)
		KH-I_Vigilin_rpt10	741..806	CDD:411841	38/64 (59%)
		KH-I_Vigilin_rpt11	817..882	CDD:411842	42/64 (66%)
		KH-I_Vigilin_rpt12	890..991	CDD:411843	50/106 (47%)
		KH-I_Vigilin_rpt13	993..1070	CDD:411844	27/76 (36%)
		KH-I_Vigilin_rpt14	1074..1144	CDD:411845	40/72 (56%)
		KH-I_Vigilin_rpt15	1147..1214	CDD:411846	21/67 (31%)