DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDLBP and BicC

DIOPT Version :9

Sequence 1:	NP_001307894.1	Gene:	HDLBP / 3069	HGNCID:	4857	Length:	1268	Species:	Homo sapiens
Sequence 2:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	126/585 - (21%)
Similarity:	216/585 - (36%)	Gaps:	166/585 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   317 SLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPS-------- 373
            |..:::..:...|..||      .|.|..|...:| :|:.::|..::.:|.| .|||
  Fly     6 SFNKLMYPSAADVAKPP------MVGLEVEAGSIG-SLSSLHALPSTTSVGS-GAPSETQSEISS 62

Human   374 ----WLH-RFIIGKKGQNLAKITQQMPKVHIE-FTEGEDKITLEGPTEDVNVAQEQIEGMVKDLI 432
                |.. |.|..|.|      .|....:|.| |.....|:      |.:..|:..||||
  Fly    63 VDSDWSDIRAIAMKLG------VQNPDDLHTERFKVDRQKL------EQLIKAESSIEGM----- 110

Human   433 NRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVS----VRIPPDSEKSNLIRIEGDPQGVQQA 493
            |..:|.       ||         :|....|.| ||    ::|...|:|...:||.|....||:|
  Fly   111 NGAEYF-------FH---------DIMNTTDTY-VSWPCRLKIGAKSKKDPHVRIVGKVDQVQRA 158

Human   494 KRELLELASRMENERTKDLI---IEQRFHRTIIGQKGERIREIRDKFPEVIINFPD-----PAQK 550
            |..:|   |.:::..|:.::   :....|..|||:.|..|:.|.|. ....|:|||     |.:|
  Fly   159 KERIL---SSLDSRGTRVIMKMDVSYTDHSYIIGRGGNNIKRIMDD-THTHIHFPDSNRSNPTEK 219

Human   551 SDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKI 615
            |:.|.|.|....||:....::            :|.|:...|...::|.
  Fly   220 SNQVSLCGSLEGVERARALVR------------LSTPLLISFEMPVMGP---------------- 256

Human   616 DLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIM 680
            :.|..:..:..|.:...:.|                  .:|..|...|||.||:..||.
  Fly   257 NKPQPDHETPYIKMIETKFN------------------VQVIFSTRPKLHTSLVLVKGS------ 297

Human   681 EECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAK--PEYHKFLI 743
                                  ...|:.|..|.:.|::.|.|.......|:::.:  |::|:.:.
  Fly   298 ----------------------EKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHEIVK 340

Human   744 GKGGGKIRKVRDSTGARVIFPAAEDKD-----QDLITIIGKEDAVREAQKELEALIQNLDNVVED 803
            ||....:..:.:.|..::|||...|.:     :..:||.|:.|.|..|:::|      |.|:...
  Fly   341 GKNNVNLLSIMERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQL------LGNLPVA 399

Human   804 SMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSD-KVTLKGAKDCVEAAKKRIQEII 867
            .:...|.:|..     ...:..:..:| ||.::..:...||. .:.:||.:..::...:..|||:
  Fly   400 LIFDFPDNHND-----ASEIMSLNTKY-GVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEIL 458

Human 868 867
Fly 459 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDLBP	NP_001307894.1	vigilin_like_KH	152..213	CDD:239087
		vigilin_like_KH	224..283	CDD:239087
		vigilin_like_KH	297..357	CDD:239087	9/39 (23%)
		vigilin_like_KH	368..425	CDD:239087	16/70 (23%)
		vigilin_like_KH	438..498	CDD:239087	17/63 (27%)
		vigilin_like_KH	509..571	CDD:239087	21/69 (30%)
		vigilin_like_KH	583..644	CDD:239087	7/60 (12%)
		vigilin_like_KH	655..717	CDD:239087	12/61 (20%)
		vigilin_like_KH	729..791	CDD:239087	16/68 (24%)
		vigilin_like_KH	802..864	CDD:239087	9/62 (15%)
		vigilin_like_KH	875..968	CDD:239087
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..944
		vigilin_like_KH	974..1035	CDD:239087
		vigilin_like_KH	1055..1118	CDD:239087
		vigilin_like_KH	1129..1191	CDD:239087
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1233..1268
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	20/66 (30%)
		vigilin_like_KH	327..393	CDD:239087	16/71 (23%)
		SAM_BICC1	805..868	CDD:188919
		SAM	807..867	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740