Protein Alignment HDC and Hdc

DIOPT Version :10

• Sequence 1: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Sequence 2: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 294/511 - (57%)
• Similarity: 373/511 - (72%)
• Gaps: 35/511 - (6%)

Human     2 MEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIM 66
            |:.:|||:||:||||||..||..:|||||.|||.|||:|..||||||.:.:.|..||.|:|||:|
  Fly     1 MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVM 65

Human    67 PGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPE 131
            ||:.||||||||||:|||.|.|||||||||||||||||||||||||||||:.||:||.||:|||:
  Fly    66 PGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPD 130

Human   132 HFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSS 196
            .|||....||||||||:|.||:||:.|||.|...|.......|...::.:|||||||.|||||||
  Fly   131 AFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSS 195

Human   197 VEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGP 261
            ||||.||.||:|:::..||:.::||:.|::|||:|.::||||.:|||||||||.|:||.|.|:|.
  Fly   196 VEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGI 260

Human   262 ISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPEFRGFLK 326
            :...||                                   ||||:||||||:||:|||||.:|:
  Fly   261 VCAEHH-----------------------------------LWLHVDAAYAGSAFICPEFRTWLR 290

Human   327 GIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRR 391
            |||.|||..||||||:|||||.|..||:|...:.:||:|.|:||:|.|||||.||||||||||||
  Fly   291 GIERADSIAFNPSKWLMVHFDATALWVRDSTAVHRTFNVEPLYLQHENSGVAVDFMHWQIPLSRR 355

Human   392 FRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTE 456
            ||::|:|||:||:|:|.||.|:|.|..:|:.||:||..|..||:||||||||||||::|.|.:||
  Fly   356 FRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITE 420

Human   457 NVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQ 512
            .:||.:...|.|..||::::.:.:||||:||..||.|||::||..||..|:.:|.:
  Fly   421 KLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTTLDDIVKDWMEIRQVASTVLEE 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDC	XP_016877583.1	Pyridoxal_deC	36..449	CDD:395219	245/412 (59%)
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	245/412 (59%)