Protein Alignment HDC and Tdc1

DIOPT Version :10

• Sequence 1: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Sequence 2: NP_610226.2
• Gene: Tdc1 / 35573
• FlyBaseID: FBgn0259977
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 231/559 - (41%)
• Similarity: 333/559 - (59%)
• Gaps: 54/559 - (9%)

Human     2 MEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIM 66
            |:.||:|:.|:|::||||||.:.:.||.|.|.:.||||:..||..||:.|:.:..:..|.|:.||
  Fly     1 MDVEEFRKYGKEVIDYICQYGTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQKIM 65

Human    67 PGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPE 131
            ||||||..|...||:|:..|:||:|||||:.||..:||:|||.||..|||..||:|.||.||||:
  Fly    66 PGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPK 130

Human   132 HFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSS 196
            .|:...|.|.|||.||.:.||..|::|:.||...|.|:| .:....:|.....|:||||.:||||
  Fly   131 AFVSDAPGSTGGGALQGSASECVLVSLITARARAISELK-GQTSVHDSVFLPSLIAYASREAHSS 194

Human   197 VEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGP 261
            ||||..::|||::.:..|::..:|.:.|::||:.|...||.|.||.||:||||.||||.::|:|.
  Fly   195 VEKATKMALVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEIGK 259

Human   262 ISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPEFRGFLK 326
            :.:                          ||        ..:|||:|.||||.:|:.||.|.|..
  Fly   260 VCR--------------------------QV--------SSIWLHVDGAYAGNSFILPEMRVFSA 290

Human   327 GIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHAN-SGVATDFMHWQIPLSR 390
            |:||||||..||:|.::.:||.:..||:|...|:...:|||:||||.: :||  |:.|:.|||||
  Fly   291 GLEYADSFNTNPNKLLLTNFDASALWVRDVMNLKSALNVNPLYLRHEHLTGV--DYRHYGIPLSR 353

Human   391 RFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLT 455
            |||::|||||.|::|::.||.::|:...:||.||.|||.|..||:....|||||.||::..:...
  Fly   354 RFRALKLWFVFRTYGIRGLQEYIRNHMALAKKFEMLVRKDERFEVRNDVHLGLVCFRMRTGDEPN 418

Human   456 ENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQH---CTSQ 517
            ..:|.:|..:|::.:.||....:.:|||.||.:..|..|||..|..|:..|..||..|   .:|.
  Fly   419 HMLLAQINHSGKMHMTPAKFNGRYVIRFCVTYEHATEKDILEAWTQIKCFAEEILRDHQLESSSV 483

Human   518 PSPRVGNLISQIRGARAWACGTSLQSVSG-AGDDPVQAR 555
            |:...|:.            .||.:.::. ||..|::.|
  Fly   484 PTTPEGSE------------RTSSEPLAPVAGKPPIKKR 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDC	XP_016877583.1	Pyridoxal_deC	36..449	CDD:395219	186/413 (45%)
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:395219	186/413 (45%)