Protein Alignment HDC and Ddc

DIOPT Version :10

• Sequence 1: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Sequence 2: NP_724163.1
• Gene: Ddc / 35190
• FlyBaseID: FBgn0000422
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 243/505 - (48%)
• Similarity: 327/505 - (64%)
• Gaps: 37/505 - (7%)

Human     2 MEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIM 66
            ||..|:::..:.|||:|.:||..:|||||.|:|:||||:..:|::|||.|:.|..:..||||:||
  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100

Human    67 PGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPE 131
            |||.||.||..|||:|...|:|:::.|||:.||.|:||||.:||||||||:.:||||.|||.||.
  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPA 165

Human   132 HFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSS 196
            .|| .....:||||:|.|.|||||:|||.|:..|:.|:|...|:.||..:..:||.|.|||||||
  Fly   166 EFL-ACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSS 229

Human   197 VEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGP 261
            ||:|||:..||::.:. .:|..:||.||:||||:|...||:|.:...|||||..||||.|.|.||
  Fly   230 VERAGLLGGVKLRSVQ-SENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGP 293

Human   262 ISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPEFRGFLK 326
            :...|:                                   ||:|:||||||:||:|||:|..:|
  Fly   294 VGNKHN-----------------------------------LWIHVDAAYAGSAFICPEYRHLMK 323

Human   327 GIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRR 391
            |||.||||.|||.|||:|:|||:..|:||...:...|:|:|:||:|...|.|.|:.||||||.||
  Fly   324 GIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYLKHDMQGSAPDYRHWQIPLGRR 388

Human   392 FRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTE 456
            ||::|||||:|.:||:|||||:|.....||.|..|...|..||:.|:.::|||.|||||.|...|
  Fly   389 FRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCFRLKGSNERNE 453

Human   457 NVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAA 506
            .:||.|...|.:.|:||.|:|...:|..:.|:||..:|:...|..:..||
  Fly   454 ALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFTQSEDMEYSWKEVSAAA 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDC	XP_016877583.1	Pyridoxal_deC	36..449	CDD:395219	205/412 (50%)
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:395219	205/412 (50%)