Protein Alignment HDC and amd

DIOPT Version :10

• Sequence 1: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Sequence 2: NP_476592.1
• Gene: amd / 35188
• FlyBaseID: FBgn0000075
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 227/527 - (43%)
• Similarity: 316/527 - (59%)
• Gaps: 39/527 - (7%)

Human     2 MEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIM 66
            |:.:|:||.|:..:|||..||..:|:..|.|:|:||||...||...||:|::|..:.|||.|:|.
  Fly     1 MDAKEFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIK 65

Human    67 PGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPE 131
            ||:.||||||||||||..||:||::|:|||.....:||:|..||||||||:.|||||||.|.||.
  Fly    66 PGLTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPA 130

Human   132 HFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSS 196
            || .|.....||||:|.:.||:.|:|:||||:..:...:.|.|:..||.:..|||||:|||::|.
  Fly   131 HF-QHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRGRLVAYSSDQSNSC 194

Human   197 VEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGP 261
            :||||:::.:.::.||..::|.|||:.|:.|||||...|.:||...|||||||.||:|.:..|..
  Fly   195 IEKAGVLAAMPIRLLPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIESLSA 259

Human   262 ISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPEFRGFLK 326
            :               || .|.                   :|||:||||||.||...|.....|
  Fly   260 V---------------CE-EFK-------------------VWLHVDAAYAGGAFALEECSDLRK 289

Human   327 GIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVA--TDFMHWQIPLS 389
            |::..||..||..|:|:|:|||:..|::|..|:..:|:|:.|||:|.:.|.:  .||.||||||.
  Fly   290 GLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLG 354

Human   390 RRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCL 454
            ||||::|:|...|:.|.:.|:.|||...|:||.||.||..|..||:.|.|.||||.||.||.|.:
  Fly   355 RRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELVAPRALGLVCFRPKGDNEI 419

Human   455 TENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAAT-LILSQHCTSQP 518
            |..:|:.:....:::::.|....:..:||.|....|...||...|..|....| |...|...::.
  Fly   420 TTQLLQRLMDRKKIYMVKAEHAGRQFLRFVVCGMDTKASDIDFAWQEIESQLTDLQAEQSLVARK 484

Human   519 SPRVGNL 525
            |..||:|
  Fly   485 SGNVGDL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDC	XP_016877583.1	Pyridoxal_deC	36..449	CDD:395219	192/414 (46%)
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:395219	192/414 (46%)