Protein Alignment HDC and b

DIOPT Version :10

• Sequence 1: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Sequence 2: NP_476788.1
• Gene: b / 34791
• FlyBaseID: FBgn0000153
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 132/538 - (24%)
• Similarity: 217/538 - (40%)
• Gaps: 112/538 - (20%)

Human    12 REMVDYICQ---YLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQ 73
            |..||.|.:   :..|.|..:|....:|..||........|..:|.|.:     |.::...:.:.
  Fly   101 RACVDEIIKLAVFQGTNRSSKVVEWHEPAELRQLFDFQLREQGESQDKL-----RELLRETIRFS 160

Human    74 SPHMHAY-----YPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHF 133
            ....|.|     |..:..: :|:|..|.||:|...:|:..:|..|.:|..|:..:.:::|.|.
  Fly   161 VKTGHPYFINQLYSGVDPY-ALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPN-- 222

Human   134 LHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNAR-LVAYASDQAHSSV 197
                 ..||.|:.....|.:...|:..||.....|.|.:      ...||: |:.:.|:.||.||
  Fly   223 -----GGQGDGIFCPGGSIANGYAISCARYRHSPESKKN------GLFNAKPLIIFTSEDAHYSV 276

Human   198 EKAGLISLVKMKF-------LPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDC 255
            ||..:.    |.|       :..::...:|...|:|.::...:.|..|:.|.||.|||.:.|||.
  Fly   277 EKLAMF----MGFGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDD 337

Human   256 LSELGPISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPE 320
            |:.:..:.|.::                                   :|:|:|||:.|.|.:..:
  Fly   338 LAGISEVCKKYN-----------------------------------MWMHVDAAWGGGALMSKK 367

Human   321 FRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDF---- 381
            :|..|.|||.|||.|:||.|.:.....|:.|..:.:..|.|..|.|..||...:....|.|
  Fly   368 YRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGD 432

Human   382 MHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVF 446
            .|  |...||....|.||:.::.|.:.|:|||.....||::|.:.||..|.||:.
  Fly   433 KH--IQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELV---------- 485

Human   447 RLKGPNCLTENV--------LKEIAK----AGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDW 499
             |:.|.|  .|:        |:|:.:    ..||..:...:::.:|.:   .|...|...:.:..
  Fly   486 -LESPEC--TNISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKK---GSMMITYQPLRQLP 544

Human   500 NLIRDAATLILSQHCTSQ 517
            |..|    |:|...|..:
  Fly   545 NFFR----LVLQNSCLEE 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDC	XP_016877583.1	Pyridoxal_deC	36..449	CDD:395219	109/429 (25%)
b	NP_476788.1	GadA	127..573	CDD:439846	125/512 (24%)