Protein Alignment HDAC2 and HDAC3

DIOPT Version :10

• Sequence 1: NP_001518.3
• Gene: HDAC2 / 3066
• HGNCID: 4853
• Length: 488
• Species: Homo sapiens
• Sequence 2: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 428
• Identity: 247/428 - (57%)
• Similarity: 332/428 - (77%)
• Gaps: 12/428 - (2%)

Human    10 KKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYI 74
            ::|.|:|:.|:||::||.||||||.|:.:||:|::||||::||:||||:||:|::|.::||||||
  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68

Human    75 KFLRSIRPDNMS----EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVN 135
            .:|:.:.|.|:.    .|:|.:..|:||||||||||||:||.:.||.|:.||.|||...:|:.:|
  Fly    69 AYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICIN 133

Human   136 WAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFH 200
            |:||||||||.||||||||||||:.||||||||.||||||||:||||||:||||.||||||.|||
  Fly   134 WSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFH 198

Human   201 KYGEY-FPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGA 264
            |||.| ||||||:.:|||..|:||:||.|:::||||:||.|:||||||.:|:.|:|:|:||||||
  Fly   199 KYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGA 263

Human   265 DSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNEL 329
            |||:|||||||:|:.|||.:||:.||..|:|.|::||||||:||||||||:||::.:|.:|.|:|
  Fly   264 DSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDL 328

Human   330 PYNDYFEYFGPDFKLHISP---SNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVH 391
            |..:|:::|.|||.||  |   |...|.|:.:|:|.|.:.::|||:|..|:|.|||...|.|...
  Fly   329 PATEYYDFFAPDFTLH--PEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDL 391

Human   392 ED--SGDEDGEDPDKRISIRASDKRIACDEEFSDSEDE 427
            |:  |..|:..|||.|||:...||.:....||.|.:.:
  Fly   392 EELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQD 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC2	NP_001518.3	HDAC2	9..374	CDD:212535	225/371 (61%)
		Histone deacetylase	9..322		203/316 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..488		14/41 (34%)
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	232/385 (60%)