Protein Alignment HDAC2 and HDAC1

DIOPT Version :10

• Sequence 1: NP_001518.3
• Gene: HDAC2 / 3066
• HGNCID: 4853
• Length: 488
• Species: Homo sapiens
• Sequence 2: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 373/487 - (76%)
• Similarity: 422/487 - (86%)
• Gaps: 4/487 - (0%)

Human     5 QGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYH 69
            |...||:||||||.||||||||||||||||||||||||||||||||||||||||||||:||||:|
  Fly     2 QSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFH 66

Human    70 SDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAV 134
            ||||::|||||||||||||:||||||||||||||||||:||||||.|||||.|||||:|.:::.:
  Fly    67 SDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICI 131

Human   135 NWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSF 199
            ||.||||||||||||||||||||||.|||||||||||||||||:|||||||||||||||||||||
  Fly   132 NWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSF 196

Human   200 HKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGA 264
            |||||||||||||||||||||||||||.|:|||:||::|..||.||||||||.:||:||||||||
  Fly   197 HKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGA 261

Human   265 DSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNEL 329
            |||:||||||||||||||.||||.||.:|||.||:||||||||||:|||||||:|||..||.|||
  Fly   262 DSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANEL 326

Human   330 PYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDS 394
            |||||||||||||||||||||||||||.||:||||.||||||||||||||||:|||||||::::|
  Fly   327 PYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDES 391

Human   395 GDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED---KKETED 456
            .|||..|.|.|:.....||||..:.|:||||||||||||:...:|...|:.|:::|   .|.:.:
  Fly   392 DDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSE 456

Human   457 KKTDVKEEDKSKDNS-GEKTDTKGTKSEQLSN 487
            ..:::|:|.:..|.: ||::....|.|...||
  Fly   457 TSSEIKDEKEKGDGADGEESTASNTNSNNNSN 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC2	NP_001518.3	HDAC2	9..374	CDD:212535	318/364 (87%)
		Histone deacetylase	9..322		272/312 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..488		39/103 (38%)
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	319/366 (87%)