Protein Alignment HDAC2 and HDAC11

DIOPT Version :10

• Sequence 1: NP_001518.3
• Gene: HDAC2 / 3066
• HGNCID: 4853
• Length: 488
• Species: Homo sapiens
• Sequence 2: NP_733048.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Alignment Length: 309
• Identity: 81/309 - (26%)
• Similarity: 127/309 - (41%)
• Gaps: 71/309 - (22%)

Human    29 HPMKPHRIRMTHNLL-----LNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLR---------- 78
            ||....:.:..|.||     |:.|.:     |.|.:.|.:::.:.|:.||:|.||
  Fly    51 HPFDAAKGKHIHKLLCAQLQLDDGSF-----YEPTELTKDQLRRIHTREYLKSLRWSMNVACIAE 110

Human    79 ----SIRPDN--MSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWA 137
                :..|:.  ...|.:.| ||.                 :.|..:||.:.|:   ...|:|..
  Fly   111 VPLMAFVPNRYIQRSYLRPM-RFQ-----------------AAGSILAGKLALD---YGWAINLG 154

Human   138 GGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTDRVMTVS 198
            ||.||.......|||...||.|.|:.|.:..    :|::.:|:|.|.|:|.|..|.....|..
  Fly   155 GGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYI-- 217

Human   199 FHKYGEY-FPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQC 262
            |..|..: :|     ||..|.:....||.  :|:..:|..|.:..|..:.:.:..::|..||...
  Fly   218 FDMYNAFVYP-----RDHVAKESIRCAVE--LRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNA 275

Human   263 GADSLSGDRLGCFNLTVKGHAKCVE----VVKTF---NLPLLMLGGGGY 304
            |.|.|.||.||...::.:|   .:|    |..||   .:|::||..|||
  Fly   276 GTDVLEGDPLGNLAISAEG---VIERDRLVFSTFRALGIPVVMLLSGGY 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC2	NP_001518.3	HDAC2	9..374	CDD:212535	81/309 (26%)
		Histone deacetylase	9..322		81/309 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..488
HDAC11	NP_733048.1	HDAC_classIV	51..336	CDD:212519	81/309 (26%)