DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC2 and HDAC4

DIOPT Version :10

Sequence 1:NP_001518.3 Gene:HDAC2 / 3066 HGNCID:4853 Length:488 Species:Homo sapiens
Sequence 2:NP_001259507.1 Gene:HDAC4 / 32278 FlyBaseID:FBgn0041210 Length:1269 Species:Drosophila melanogaster


Alignment Length:438 Identity:100/438 - (22%)
Similarity:168/438 - (38%) Gaps:99/438 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    29 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQ 93
            ||....|::.....|....|.::.:..|..|||.||:...|::.:.....|    |..:.|:   
  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSR--- 917

Human    94 RFNVGEDCPVFDGLF--EFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL--------------- 140
                    |..:...  .|.:||.|| .|......|...|..|...|.|.               
  Fly   918 --------PKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974

Human   141 ---------HHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTD 192
                     |||:.:.|.|||:.|.|.:| .:||:..    :|:|.:|.|:|||:|.::|||.:.
  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSP 1038

Human   193 RVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNF----PMRDGIDDESYGQIFKPIISKVME 251
            .::.:|.|::  |.:|||||...:.|:|.|..:.||.    .:...:.|..|...|:.::..:..
  Fly  1039 DILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIAR 1103

Human   252 MYQPSAVVLQCGADSLSGD--RLG-------CFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIR 307
            .:.|..|::..|.|:.:|.  .||       ||....:      |:::..|..:::...|||.: 
  Fly  1104 SFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDL- 1161

Human   308 NVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHIS-PSNMTNQNTPEYMEKIKQRLFENL 371
                        |..|:...|.......:...|..|..:. |......||.:....|:|..:..:
  Fly  1162 ------------AAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCV 1214

Human   372 RMLPHAPGVQ-----------------MQAIPEDAVHEDSGDEDGEDP 402
            |||.|..|:.                 |..:...::|.....:|.|:|
  Fly  1215 RMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEP 1262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC2NP_001518.3 HDAC2 9..374 CDD:212535 91/391 (23%)
Histone deacetylase 9..322 81/338 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..488 4/14 (29%)
HDAC4NP_001259507.1 ClassIIa_HDAC_Gln-rich-N 43..>87 CDD:421006
HDAC_classIIa 837..1211 CDD:212544 90/385 (23%)
Blue background indicates that the domain is not in the aligned region.

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