DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arxa and Rx

DIOPT Version :9

Sequence 1:	NP_571459.1	Gene:	arxa / 30657	ZFINID:	ZDB-GENE-990415-15	Length:	453	Species:	Danio rerio
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	156/597 - (26%)
Similarity:	225/597 - (37%)	Gaps:	191/597 - (31%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MSSQYDDDSRDRSECKSKSPTVL------SSYCIDSILGRRSPCKVR------------------ 41
            :::|..:.....|:....|||..      .:|.::|.....:|.::.
  Fly   336 LAAQAQEQQNQHSKYAKSSPTGAGPPPPPGAYFMESQTAPVAPSQINYDERSMSSASDLEEDDDD 400

Zfish    42 ----QLGAQSLPAPVRPDHEMTTEVTSKENSFDSDMHLPPKLRRLYGPGGKYLDSGRGFHE--HL 100
                ||...|.|.| .|..::..:..|.....|.:   .|||.....|||.|....|...|  |.
  Fly   401 AAKLQLDVTSPPTP-SPRGQLAAKRKSAGVFCDDN---EPKLANGQLPGGNYGIRPRSMEEVHHQ 461

Zfish   101 EKG---ERERLLDQACESLKISQAPQVSISRSKSYRENAPFSQSDEGQSPEHMAQELVELSTLKF 162
            ::.   ::::...|..:.|:..|..|.....|.:...|...:..|.|:             .|..
  Fly   462 QQSHHHQQQQQQQQQQQQLQQQQGFQHDFRNSGNGNPNGNSNSGDHGE-------------RLNA 513

Zfish   163 EEDVVKEEACGDNSLSPKDEESLHNDGDVKDGEDSVCLSAGSDSE---EGMLKRKQRRYRTTFTS 224
            :.|.:...:|..:       |.|:.....:.||.   :::|||.|   :...|:|.||.|||||:
  Fly   514 DSDSLVNGSCASS-------EDLNQTNSSEQGEK---ITSGSDDEGQDDNCAKKKHRRNRTTFTT 568

Zfish   225 YQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA-----GVQAHPTG 284
            |||.||||||:|:|||||::||||||:::|.|.||||||||||||||::||:     |: .|.|.
  Fly   569 YQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGL-THFTQ 632

Zfish   285 LP-----------------------FPG---------PLAAAHPLS----------------HYL 301
            ||                       .||         |.....|||                |:.
  Fly   633 LPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHA 697

Zfish   302 EGGPFP----------------------PHPH------------PALESAWTAAAAAAAAFPGLA 332
            ..||.|                      ||||            |.|......|.:..:...|:.
  Fly   698 HNGPPPPHVGHGGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHATSLGSPHHGVT 762

Zfish   333 P--PPNSSALPP---ATPLGLGTFLGTAMFRHPAFIGPTF-----------------GR-LFSSM 374
            |  .|..|:|||   ||.:.:.:...::........||..                 || |.|.:
  Fly   763 PLGTPLHSSLPPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDL 827

Zfish   375 GPLTSASTAAALLRQTAPPV---------ESPVQPSAALPEPPSSSSST-AADRRASSIAALRLK 429
            ...:::|...:.|.:.|...         :||..|    |.|....||| ..|.|::|||.||:|
  Fly   828 DAGSTSSNPGSSLDKCAASANIELLDVGRDSPPPP----PTPTGKGSSTPPTDMRSNSIATLRIK 888

Zfish   430 AKEHSAQLTQLN 441
            ||||   |..||
  Fly   889 AKEH---LDNLN 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arxa	NP_571459.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..75		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..149		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..212		9/44 (20%)
		Homeobox	219..271	CDD:278475	40/51 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..418		9/37 (24%)
		OAR	417..434	CDD:281777	11/16 (69%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	421..434		9/12 (75%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	40/51 (78%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	10/15 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920