DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l1camb and sdk

DIOPT Version :9

Sequence 1:	NP_571458.1	Gene:	l1camb / 30656	ZFINID:	ZDB-GENE-980526-512	Length:	1269	Species:	Danio rerio
Sequence 2:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster

Alignment Length:	1449	Identity:	334/1449 - (23%)
Similarity:	554/1449 - (38%)	Gaps:	344/1449 - (23%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MPPVQSQPAGRRGQKRTHLHLLLLFLSAAQT------HAYIQIPHDYTYNKLKQAPEFTTQPVPH 59
            ||   |||      |...|..:|:.|....:      .|.:|..:.....:..|||.|||.|...
  Fly    26 MP---SQP------KLASLLAVLVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSS 81

Zfish    60 TAFSLDDVN--LACEASGDPSPSFRWVKDGKQFGEVLSESGTLTPHPTMDLHFYQ---------G 113
            .:...:...  |.|.|.|.|.|::||:|||...|:..|.            .||:         |
  Fly    82 GSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSS------------QFYRFHSTRREDAG 134

Zfish   114 TYRCYAANELGT----------AVSNLVHLTTEPVPSLAKVKKQKRRAYEVGESAVLRCNPPKSS 168
            :|:|.|.|:.|:          |...:...|||           .|.....|..|:....|.:|.
  Fly   135 SYQCIARNDAGSIFSEKSDVVVAYMGIFENTTE-----------GRLTVISGHPAIFDMPPIESI 188

Zfish   169 VTPKIHWM--------DMQFHHIPLNERVTISRDGNLYFANLIANDSRDDYTCNAHYINASIILP 225
            ..|.:.|.        |:::.....|:.:.:|.|.|          .|..|...|  ||..  |.
  Fly   189 PVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADEN----------DRKGYRAKA--INTQ--LG 239

Zfish   226 KEPMSIYVTPSNS-----------VVKNRRAKLHHPAGARSSYLVLRGQTLTLECIPEGLPTPEV 279
            ||..|.:|..:.|           :|:.:..|:....|           .:.|:||....|..|:
  Fly   240 KEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTG-----------VVELQCIANARPLHEL 293

Zfish   280 H--WDRIDSALSPNRTKKLYNNRW---LQIDNVLESDDGEYVCTAR---NSENSVKHHYTVTVEA 336
            .  |.:...|:.....:...|:.|   |.:.....|..|||.|..|   ....:|.....:.:..
  Fly   294 ETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILE 358

Zfish   337 AP-YWTRRPEEHLYAPGETVRLDCQADGIPAPNITWSINGVPVSGTDVDPRRRVSSGK------- 393
            .| ::|....|.....|..|:|.|...|.|.|.:.|..|...|..       .:.||:
  Fly   359 PPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDA-------HIESGRYTLNTDN 416

Zfish   394 -LILSNVEFSDTAVYQCEAVNKHGSILINTHVHV------------------------------- 426
             |::..:...|.|::||.|:|:.|....:|.:.|
  Fly   417 TLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEK 481

Zfish   427 --------------------VELPAQILTPDERLYQATAGQTVMLDCRTFGSPLPKIHW-----E 466
                                :|||.|.:|       |..|:...:.||..|||.|.|.|     :
  Fly   482 GSESGSSDRRKEFRFASAPIMELPPQNVT-------ALDGKDATISCRAVGSPNPNITWIYNETQ 539

Zfish   467 ILDSIPALSNAKISQMTNGSLKISNVSEEDSNRYTCSVSETNKSISAE--LEVLNRTKIVGPPQN 529
            ::|     .::::..:.:|.|.|||:...|:..|.|..:....|:..|  |.||.||:|:.||.:
  Fly   540 LVD-----ISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVD 599

Zfish   530 LHVIRGSDAILHCKYTVDHNLKSPTVQWKKDGHKITASTSNDKYH-EIEGSLKVLDVQMEDMGIY 593
            ..|:.|..|.|.||.:.|.::.. .:.|.::|...|..:::.:.. :.:|.|::..|:..|:|.|
  Fly   600 TTVLLGLTATLQCKVSSDPSVPY-NIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSY 663

Zfish   594 SCGVSTTLDSDTASGYITVQDKPDPPQSLK---LSEKMERSVTISWMPSVENNSPVTEYVIEMNE 655
            :|.|::...::|.:..::|.:.|.||.::|   |.|..:||:.:||.|..:.|||:::::|:..|
  Fly   664 ACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRRE 728

Zfish   656 ----GETPDE-GQW-QKYRSVSQDIRQLEI-HLQPYSKYHFQIRAVNSIGTSAPSESSLSYSTPA 713
                |..||. ..| .:..:||.|.|.:.: :|:..:.|.|::.|||.:|..:|||.|.....|.
  Fly   729 VSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQ 793

Zfish   714 AKPDRNPENVMTLSTDPKSMIISWQEMDRRQFNGPGFQYKVFWRRAADSGAHWTESSVSNPP--- 775
            ..|...|...:..:.....:|..||.......||....|.:.:|....:...|:..:::|..
  Fly   794 EAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRN 858

Zfish   776 LLVNNTGTFVSFEIKVQAVNDLGAAPEPLTVIGY--------SGEDFPLEAPSALSVTELQKTSV 832
            .|:....|:..:.:::.|.|::|        :|.        :.|..|...|:.:.|..:..|:.
  Fly   859 FLIQELITWKDYIVQIAAYNNMG--------VGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAA 915

Zfish   833 MVRWSPVRPESVRGHLLGYKIYLRMKGPSGRLRAG------RSPAVGNPTVIEVPADAAEKIVSD 891
            ..||:|..|:.:.|...||||....:    ||..|      |......|::|: |......|:..
  Fly   916 RCRWTPPNPQQINGINQGYKIQAWQR----RLIDGEWRDIERRMKTVPPSLID-PLAEQTAILGG 975

Zfish   892 LQYYSDYTLTITAFNSKGEGPHSEESSFSTPEGAPGPVLFLPFDSPSESEITLRWEAPHKPNGEI 956
            |:.:::|.:::..|...|:|..|.:.:..|.:..|..|..|.||..|:..:.:.|..|...||.:
  Fly   976 LEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGIL 1040

Zfish   957 RGYLLQYQEVVIGSESPQHVESIDLPA-VTEFTLKNLNPESRYTFHLSARNSAGDGAP---AIQS 1017
            .||.::||.    .:.|..::|.:|.| .||.|:..|...:.|.|.:.|....|.|.|   .|||
  Fly  1041 TGYTVRYQV----KDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQS 1101

Zfish  1018 GATLLDGEPPSVINMTAGET-SVNLSWVPG-DRHRNVGFSFRYLK-KIEG-----AEWEESEKIN 1074
            |...:....|:.:.::..|. ||.|.:.|| |.:.::      .| |:||     ..|....:||
  Fly  1102 GVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSI------TKWKVEGQTARNMTWFTICEIN 1160

Zfish  1075 STQA-FYQLQGLDSGVIYHLQVLSGN-------TSYDWDFKTIYS-------------------- 1111
            ...| ...:.||.....|.|::.:.|       :....||:||.:
  Fly  1161 DPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLR 1225

Zfish  1112 --------PEWHKSPRNF--------ATEGWFIGLISALVLLLLVLLLLCYIKKSKGGKYSVKDK 1160
                    .||:.:||.:        .|.|                 .:.|:.:|    ..::|
  Fly  1226 VRWIPLQQTEWYGNPRGYNISYKQLVKTPG-----------------TIKYVPRS----VVIED- 1268

Zfish  1161 EEGQGDAANQKLKDDAFGEYRSLESDMEKCSISQPSGCESKRS------SNDSLADYGDSVDIQF 1219
                 ..||..:. |:..|:...|..|..|:   ..|| ||.|      :.:::..|| .:|:|.
  Fly  1269 -----HTANSHVL-DSLEEWTLYEVKMNACN---DVGC-SKESDTAVERTREAVPSYG-PLDVQA 1322

Zfish  1220 NEDGSFIGQYSGRRDPRGH 1238
            |...|..........||.|
  Fly  1323 NATSSTTVVVQWGEVPRQH 1341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l1camb	NP_571458.1	Ig	69..133	CDD:299845	22/82 (27%)
		Ig	140..231	CDD:299845	20/98 (20%)
		IG_like	255..334	CDD:214653	17/86 (20%)
		Ig3_L1-CAM	265..335	CDD:143284	17/77 (22%)
		IG_like	344..426	CDD:214653	22/89 (25%)
		Ig	352..427	CDD:299845	22/133 (17%)
		IG_like	441..517	CDD:214653	22/82 (27%)
		IGc2	446..505	CDD:197706	18/63 (29%)
		I-set	522..607	CDD:254352	22/85 (26%)
		IGc2	535..595	CDD:197706	15/60 (25%)
		FN3	616..706	CDD:238020	34/99 (34%)
		FN3	719..798	CDD:214495	14/81 (17%)
		FN3	817..921	CDD:238020	26/109 (24%)
		FN3	926..1014	CDD:238020	28/91 (31%)
		FN3	1025..>1095	CDD:238020	20/78 (26%)
		Bravo_FIGEY	1148..1233	CDD:290593	20/90 (22%)
sdk	NP_001284756.1	Ig	71..157	CDD:299845	27/97 (28%)
		I-set	72..150	CDD:254352	26/89 (29%)
		Ig	172..245	CDD:299845	19/86 (22%)
		IG_like	280..356	CDD:214653	17/75 (23%)
		Ig	280..343	CDD:299845	16/62 (26%)
		IG_like	375..450	CDD:214653	21/81 (26%)
		Ig	378..447	CDD:143165	19/75 (25%)
		Ig	506..587	CDD:299845	24/92 (26%)
		IG_like	506..587	CDD:214653	24/92 (26%)
		I-set	592..682	CDD:254352	22/90 (24%)
		Ig	595..682	CDD:299845	21/87 (24%)
		FN3	686..789	CDD:238020	35/102 (34%)
		FN3	798..893	CDD:238020	16/102 (16%)
		FN3	901..1005	CDD:238020	26/108 (24%)
		fn3	1011..1094	CDD:278470	26/86 (30%)
		FN3	1108..1202	CDD:238020	23/99 (23%)
		FN3	1210..1308	CDD:238020	21/129 (16%)
		fn3	1317..1402	CDD:278470	7/25 (28%)
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910