DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTT and STE6

DIOPT Version :10

Sequence 1:NP_002102.4 Gene:HTT / 3064 HGNCID:4851 Length:3144 Species:Homo sapiens
Sequence 2:NP_012713.1 Gene:STE6 / 853671 SGDID:S000001692 Length:1290 Species:Saccharomyces cerevisiae


Alignment Length:774 Identity:145/774 - (18%)
Similarity:265/774 - (34%) Gaps:285/774 - (36%)


- Green bases have known domain annotations that are detailed below.


Human  1239 LKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCF 1303
            |.::||:...|:...:...|.|:              |.||:   .||..|..:|:|:..||...
Yeast   288 LNINDVITCFHSCIMLGSTLNNT--------------LHQIV---VLQKGGVAMEKIMTLLKDGS 335

Human  1304 SREPMMATVCVQQLLKTLFGTNLASQ---FDGLS-SNPSKSQGRAQRLGSSSVRPGLYHYCFMAP 1364
            .|.|:..||..|      |..:.|:.   |..:| |.||              ||          
Yeast   336 KRNPLNKTVAHQ------FPLDYATSDLTFANVSFSYPS--------------RP---------- 370

Human  1365 YTHFTQALADASLRNMVQAEQENDTSGWFDVLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEP 1429
                    ::|.|:|:    ..|.::|.|..:             |.|:.:.|:.:.|       
Yeast   371 --------SEAVLKNV----SLNFSAGQFTFI-------------VGKSGSGKSTLSN------- 403

Human  1430 LVIKALKQYTTTTCVQLQK-QVLD--LLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVG--QF 1489
            |:::....|..:..:.... |.:|  ||.:.:.:....|.|.:|.:....:|...:.:...  ..
Yeast   404 LLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCST 468

Human  1490 RESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQL---CDGIMASG----RKAVTHAIPALQPI 1547
            .|:..:|.:.....:|   :|:    |:.:|..::.   ..|:..||    |.|:..|.....||
Yeast   469 NENRHLIKDACQMALL---DRF----ILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPI 526

Human  1548 VHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQI 1612
               ||:....:..|.         |..::|::.|::                     |::....|
Yeast   527 ---LFLDEAVSALDI---------VHRNLLMKAIRH---------------------WRKGKTTI 558

Human  1613 ADIILPMLAKQQMHIDSHEALGVL--------NTLFEILAPSSLRPVDMLLRSMFVTPNTMASVS 1669
                  :|..:...|:|.:.|.::        .|..|:||                .|.|     
Yeast   559 ------ILTHELSQIESDDYLYLMKEGEVVESGTQSELLA----------------DPTT----- 596

Human  1670 TVQLW--ISGILAILRVLISQSTEDIVLSRIQELSFSPYLISCTVINRLRDGDSTSTLEEHSEGK 1732
            |...|  :....:..:.::...||:..:..::  ||:                  |.||....|.
Yeast   597 TFSTWYHLQNDYSDAKTIVDTETEEKSIHTVE--SFN------------------SQLETPKLGS 641

Human  1733 QIKNLP-EETFSRFLLQLVGILLEDIVTKQLKVE-------MSEQQHTFYCQELGTLLMCLIHIF 1789
            .:.||. :||......:.:.....::.|:::|||       :.:|::|.  ...|..|:.:|.|.
Yeast   642 CLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTE--SSTGPQLLSIIQII 704

Human  1790 KSGMFRRITAAATRLFRSDGCGGSFYTLDSLNLRARSMI-----------TTHPALVLLWCQILL 1843
            |            |:.:|              :|.:.::           .|:|.....:..:|.
Yeast   705 K------------RMIKS--------------IRYKKILILGLLCSLIAGATNPVFSYTFSFLLE 743

Human  1844 -LVNHTDYRWWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGMCNREIVRRGALILFC-D 1906
             :|..||       .:|...|.|:...||   :.|      :||..|:.|   ..:|.|:..| :
Yeast   744 GIVPSTD-------GKTGSSHYLAKWSLL---VLG------VAAADGIFN---FAKGFLLDCCSE 789

Human  1907 YVCQNLHDS--EHLT-----W-------------LIVNHIQDLISLSHEPPVQDFISAV 1945
            |...:|.:.  |.||     |             |::|.::||.||     |.:|:||:
Yeast   790 YWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSL-----VSEFLSAM 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTTNP_002102.4 Sufficient for interaction with TPR. /evidence=ECO:0000269|PubMed:15654337 3..13
CAG repeat region 18..40
HEAT repeat 133..155 CDD:293787
HEAT repeat 169..197 CDD:293787
HEAT 1 206..243
HEAT repeat 210..240 CDD:293787
HEAT 2 248..285
HEAT repeat 249..278 CDD:293787
HEAT 3 318..362
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..471
Interaction with ZDHHC17. /evidence=ECO:0000269|PubMed:28757145 493..504
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 519..585
HEAT 4 804..841
HEAT 807..936 CDD:441023
HEAT 5 904..942
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1178..1227
DUF3652 1515..1555 CDD:463554 12/46 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2332..2353
Nuclear export signal. /evidence=ECO:0000250 2397..2406
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2635..2664
STE6NP_012713.1 MdlB 1..592 CDD:440747 78/428 (18%)
MdlB 702..1290 CDD:440747 40/192 (21%)
Blue background indicates that the domain is not in the aligned region.

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