Protein Alignment HTT and FAS1

DIOPT Version :10

• Sequence 1: NP_002102.4
• Gene: HTT / 3064
• HGNCID: 4851
• Length: 3144
• Species: Homo sapiens
• Sequence 2: NP_012739.1
• Gene: FAS1 / 853653
• SGDID: S000001665
• Length: 2051
• Species: Saccharomyces cerevisiae
• Alignment Length: 2155
• Identity: 378/2155 - (17%)
• Similarity: 648/2155 - (30%)
• Gaps: 801/2155 - (37%)

Human    74 PPPPPGPAVAEEP----------------LHRPKKELSATKKDRV-NHCLTICENIVAQSVRNSP 121
            |.|..|.|..:||                |..|.|   ..:.|:| |.|||..||...
Yeast    42 PEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSK---VGQFDQVLNLCLTEFENCYL------- 96

Human   122 EFQKLLGIAMELFLLCSDDAESDVRMV-ADECLNKVIKALMDSNLP---RLQLELYKEIKKNGAP 182
            |...:..:|.:|.      .|:|..:| ..|.:...|.|.:.:..|   :....|::.:.:..|.
Yeast    97 EGNDIHALAAKLL------QENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQ 155

Human   183 ---------------RSLR----------AALWRFA--ELAHLVR----PQKCRPYLVNLLPCLT 216
                           ..||          ..|.:|:  .|:.|:|    .:|.....:|:|..|.
Yeast   156 LVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLE 220

Human   217 RTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRT----AAG--- 274
            ..|..|::....::..:.|.|          ..|::......|.|...:|...|:    |.|
Yeast   221 NPSNTPDKDYLLSIPISCPLI----------GVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQ 275

Human   275 ---SAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSL 336
               :||:|.:......:|            |.|....:.|..:||.....|....|...:.:.||
Yeast   276 GLVTAVAIAETDSWESFF------------VSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSL 328

Human   337 KGSFGVTRKEMEVSPSAEQLVQVY-ELTLHHT---QHQDHNVVTGALELLQQLFRTPPPELLQTL 397
            :.:.||....:.:|...::.||.| ..|..|.   :..:.::|.||    :.|..:.||:.|..|
Yeast   329 ENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGA----KNLVVSGPPQSLYGL 389

Human   398 TAVGGIGQLTAAKEESG-GRSR------------------------------------------- 418
            ...     |..||..|| .:||
Yeast   390 NLT-----LRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVS 449

Human   419 ----------------------SGSIVELIAG-------------------------GGSSCSPV 436
                                  ||||.|.|..                         ||:|...|
Yeast   450 FNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGV 514

Human   437 LSRKQKG-----KVLLGEEEALEDD----SESRSDVSSSALTAS-----------VKDEISGELA 481
            |:.:.|.     .::.|..:...||    .:...||:|:.|..:           :|:: ||::.
Yeast   515 LTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKLIKNK-SGKIF 578

Human   482 ASSGVS-------------TPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILS 533
            ..:..|             ||.:...|.:.....:.:|::.......|....::|.|.....|..
Yeast   579 VETKFSKLIGRPPLLVPGMTPCTVSPDFVAATTNAGYTIELAGGGYFSAAGMTAAIDSVVSQIEK 643

Human   534 HSSSQVSAVPSDPAMDLNDGTQASSPISDSS---QTTTEGPDSAVTPS-DSSEIVLDGTDNQYLG 594
            .|:..::.:..:|.| |..|......:....   |..|.|   |..|| :.:...::....:|||
Yeast   644 GSTFGINLIYVNPFM-LQWGIPLIKELRSKGYPIQFLTIG---AGVPSLEVASEYIETLGLKYLG 704

Human   595 LQIGQPQDEDEEATGILPDEASEAFRNSSMALQ-------------QAH--LLKNMSHCRQPSDS 644
            |:.|. .|...:...|     ::|..|..:|||             .||  :|:..|..|:..:.
Yeast   705 LKPGS-IDAISQVINI-----AKAHPNFPIALQWTGGRGGGHHSFEDAHTPMLQMYSKIRRHPNI 763

Human   645 SVDKFVLRDEATEPGDQENKPCRIKGDIGQSTDDDSAPLVHCVRLLSASFLLTG----------- 698
            .:                     |.|. |..:.||:.|            .|||
Yeast   764 ML---------------------IFGS-GFGSADDTYP------------YLTGEWSTKFDYPPM 794

Human   699 -------GKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVP---------------- 740
                   |..|::. ::|:.|..  |..|:.|...: |:..:.:.||.|
Yeast   795 PFDGFLFGSRVMIA-KEVKTSPD--AKKCIAACTGV-PDDKWEQTYKKPTGGIVTVRSEMGEPIH 855

Human   741 ------------LDTTEY------------PEEQYVSDILNYIDHGDP-------QVRGATAI-- 772
                        .|.|.:            .:..|:...|| .|...|       |.|....:
Yeast   856 KIATRGVMLWKEFDETIFNLPKNKLVPTLEAKRDYIISRLN-ADFQKPWFATVNGQARDLATMTY 919

Human   773 --LCGTLICSILSRSRFHVGDWMG-TIRTLTGN-------------TFSLADCIPLLRKTLKDES 821
              :...|:..:..||   ...|.. |.||.||:             |.||.....||.|  .||:
Yeast   920 EEVAKRLVELMFIRS---TNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDK--PDEA 979

Human   822 SVTCKLACTAVR---------NCVMSLCSSSYSE-LGLQLIID---VLTLRNSSYWLVRTELLET 873
            ......|..|.|         :..:|:|.:...: :....::|   .:..:..|.|  ::|.||.
Yeast   980 IEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLW--QSEHLEA 1042

Human   874 LAEIDFRLVSFLEAKA----------------ENLHRG-----AHHYTG---------------- 901
            :.:.|.:....|....                :.:|.|     .|.|.|
Yeast  1043 VVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGES 1107

Human   902 LLKLQERVLNNVVIHLLGDEDPRV-----------------------RHVAAASLIRLVPKLFYK 943
            .:.:|.:|.::.|     .||..|                       ||.:.........|:|.
Yeast  1108 PVDVQSQVDSSSV-----SEDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFV- 1166

Human   944 CDQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVI 1008
                 ::|:..|.:....:.:::....|   |..:|.|::...:| .|.|::....::.|:
Yeast  1167 -----SNPIRKVFKPSQGMVVEISNGNT---SSKTVVTLSEPVQG-ELKPTVILKLLKENI---- 1218

Human  1009 AAVSHELITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMIL 1073
              :..|:|.:.|..   |...:|.||....|        ..|..|:|...|.|..       .|.
Yeast  1219 --IQMEMIENRTMD---GKPVSLPLLYNFNP--------DNGFAPISEVMEDRNQ-------RIK 1263

Human  1074 TLLSSAW----FPLDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAATKQEEVWPALGDR 1134
            .:....|    |.||.....   ::.|.....:|.:....:.|.........::.:....|..|.
Yeast  1264 EMYWKLWIDEPFNLDFDPRD---VIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDF 1325

Human  1135 ALV----PMVEQLFSH-----LLKVINICAHVLDDVAPGPAIK-----------AALPSLTNPPS 1179
            |:|    .:::.:|.:     |||::    |:.:.....|..|           |.:.|:.|.|:
Yeast  1326 AIVVGWRAIIKAIFPNTVDGDLLKLV----HLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPT 1386

Human  1180 ------LSPIRRKGKEKEPGEQASVPLSPKKGSEASAASRQSDTSGPVTTSKSSSLGSFYHLPSY 1238
                  :..:.|.||                               ||....|    ||::..:|
Yeast  1387 GKIVDVVGTLSRNGK-------------------------------PVMEVTS----SFFYRGNY 1416

Human  1239 LKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSA---------LDVLSQILELATLQDIGKCVEE 1294
            ....:..:.|   .:....:...|.|....|||.         .|:|::.|...|..::......
Yeast  1417 TDFENTFQKT---VEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNAN 1478

Human  1295 ILGYLKSCFS----REPMMATV---------------CVQQLLKTLFGT-----NLASQ-----F 1330
            |...:| ||.    ..|...||               .|...||....|     ||.:.     .
Yeast  1479 IFSSVK-CFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVL 1542

Human  1331 DGLSSNPSKSQGRAQRLG---------------------------SSSVRPGLYHYC-------- 1360
            |  |..||.::..|:..|                           |:|||..:.::.
Yeast  1543 D--SYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRV 1605

Human  1361 ---------FMAPYTHFTQALADASL---RNMVQAEQEND-----TSGWFDVLQKVSTQLKT--- 1405
                     .:.|.|....::....:   |.:::.|..|:     .:|..::.|.|:|.:.|
Yeast  1606 RGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQG 1670

Human  1406 --------NLTSVTK------NRADKN------------AIHNHIRL------------------ 1426
                    :|...:|      ||||.:            .|:|.:.|
Yeast  1671 SQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSA 1735

Human  1427 --FEPLV---------IKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYC------------LLD 1468
              ||.:|         .|.:.:::|:...:.:|.:|. ..|..|..:...            |:.
Yeast  1736 MIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLS-ATQFTQPALTLMEKAAFEDLKSKGLIP 1799

Human  1469 SDQVFIGFVLKQFEYI-EVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCD----- 1527
            :|..|.|..|.::..: .:......|:::..:|:        |..:.| :.:|:     |
Yeast  1800 ADATFAGHSLGEYAALASLADVMSIESLVEVVFY--------RGMTMQ-VAVPR-----DELGRS 1850

Human  1528 --GIMA--SGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLE 1588
              |::|  .||.|.:.:..|||.:|..:....|.........:|.|:.|....|..|.....||.
Yeast  1851 NYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLN 1915

Human  1589 MFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQMHIDSHEALGVLNTLFEIL----APSSLR 1649
            ...|                  |..|||....:.....::.|        ||||:    ..|:::
Yeast  1916 FIKL------------------QKIDIIELQKSLSLEEVEGH--------LFEIIDEASKKSAVK 1954

Human  1650 PVDMLLRSMF 1659
            |..:.|...|
Yeast  1955 PRPLKLERGF 1964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTT	NP_002102.4	Sufficient for interaction with TPR. /evidence=ECO:0000269|PubMed:15654337	3..13
		CAG repeat region	18..40
		HEAT repeat	133..155	CDD:293787	5/22 (23%)
		HEAT repeat	169..197	CDD:293787	7/54 (13%)
		HEAT 1	206..243		7/36 (19%)
		HEAT repeat	210..240	CDD:293787	7/29 (24%)
		HEAT 2	248..285		10/46 (22%)
		HEAT repeat	249..278	CDD:293787	8/38 (21%)
		HEAT 3	318..362		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..471		6/25 (24%)
		Interaction with ZDHHC17. /evidence=ECO:0000269|PubMed:28757145	493..504		1/10 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..585		14/69 (20%)
		HEAT 4	804..841		11/45 (24%)
		HEAT	807..936	CDD:441023	31/201 (15%)
		HEAT 5	904..942		9/60 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1178..1227		6/54 (11%)
		DUF3652	1515..1555	CDD:463554	12/48 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2332..2353
		Nuclear export signal. /evidence=ECO:0000250	2397..2406
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2635..2664
FAS1	NP_012739.1	FAS_N	5..131	CDD:407694	26/104 (25%)
		SAT	158..413	CDD:465005	58/285 (20%)
		Acyl_transf_1	<335..493	CDD:471802	27/166 (16%)
		NMO	590..>821	CDD:367316	50/277 (18%)
		DUF1729	727..1074	CDD:369827	67/392 (17%)
		FAS_meander	1134..1271	CDD:407799	28/170 (16%)
		hot_dog	1284..1406	CDD:469797	23/156 (15%)
		FAS_MaoC	1536..1660	CDD:239531	16/125 (13%)
		Acyl_transf_1	1663..2037	CDD:395567	62/343 (18%)