DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smad1 and Mad

DIOPT Version :9

Sequence 1:	NP_571431.2	Gene:	smad1 / 30628	ZFINID:	ZDB-GENE-991119-8	Length:	472	Species:	Danio rerio
Sequence 2:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	341/472 - (72%)
Similarity:	375/472 - (79%)	Gaps:	39/472 - (8%)

- Green bases have known domain annotations that are detailed below.

Zfish     5 SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELERALSCPGQPSNCVTIPR 69
            |||||||||||:|||||||||||||||||||:|||||||:|||:||||||||||||||.||||||
  Fly    89 SLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVTIPR 153

Zfish    70 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALECCEFPFGSKQKDVCINPYHYKRVDSPV 134
            |||||||||||||||||||||||||||||||||||.||.|::||.:|||:|||||||||||:|||
  Fly   154 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPV 218

Zfish   135 LPPVLVPRNSEFNAKLSMLPRFRNPLHQTEPPMPQNATFPDSFPQQPANALPFTPNSPTNSYP-S 198
            ||||||||:|||....||| :|.   |..||.||.|.::               .||..||:. |
  Fly   219 LPPVLVPRHSEFAPGHSML-QFN---HVAEPSMPHNVSY---------------SNSGFNSHSLS 264

Zfish   199 SPNSGTGSTATFPHSPSS--SDPGSPF-QMPETPPPAYMPPEEPMTQDCPQPMDTNLLAPNLPLE 260
            :.|:..|       ||||  |:|.||: .:..||||||.|.|:..:.:   |.|...|..
  Fly   265 TSNTSVG-------SPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNN---PNDGGQLLD----- 314

Zfish   261 ISNRTDVHPVAYQEPKHWCSIVYYELNNRVGEAFLASSTSVLVDGFTDPSNNRNRFCLGLLSNVN 325
             :...||..|:|.||..|.||.|||||.||||.|..::.||:|||||:||||.:|.|||.|||||
  Fly   315 -AQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVN 378

Zfish   326 RNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSRCSLKIF 390
            |||||||||||||||||||||.|||||||||||:||||||||||||||||:||||||..||||||
  Fly   379 RNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIF 443

Zfish   391 NNQEFAELLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD 455
            ||||||:||:||||:||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   444 NNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD 508

Zfish   456 KVLTQMGSPHNPISSVS 472
            |||||||||||.|||||
  Fly   509 KVLTQMGSPHNAISSVS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smad1	NP_571431.2	MH1_SMAD_1_5_9	9..132	CDD:199814	110/122 (90%)
		DUF4045	<110..275	CDD:330572	70/168 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..238		28/83 (34%)
		MH2_SMAD_1_5_9	272..472	CDD:199822	172/199 (86%)
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	110/122 (90%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	172/199 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1166
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21196
Inparanoid	1	1.050	700	1.000	Inparanoid score	I650
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm26196
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010