DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btd and CG32751

DIOPT Version :9

Sequence 1:	XP_006252671.1	Gene:	Btd / 306262	RGDID:	1305316	Length:	535	Species:	Rattus norvegicus
Sequence 2:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	159/565 - (28%)
Similarity:	226/565 - (40%)	Gaps:	129/565 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat    26 FLLGCSALALGVC-----SASLEHGEAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVY 85
            |.|.|  ||||:.     .|||  .:.::|.|.|.|    ..|:. |||          .||..|
  Fly     8 FFLFC--LALGLMLNLSQQASL--FKRDFYTAGVVE----FEPSN-ELS----------DNLAGY 53

  Rat    86 EQQVMAAAQKGAHIIVFPEDGIHGFNFTRTSIYPFLDLMPSPRLVSWNPCL-EPFRFNDTEVLQR 149
            .:.:.:.......||||||..::....|        ..:|:|. ...|||| :|......|.|..
  Fly    54 LEIIQSQNATSTDIIVFPESTLNSAGST--------TFVPNPE-DQINPCLSDPNATYYEEFLVT 109

  Rat   150 LSCMAIKGKMFLVANLGTKQPC--LGSDP-GCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEE 211
            |||.|.....::|.||..||.|  :..|. .|..:|...|||||.|...|.:|.||||.:||.|.
  Fly   110 LSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLYGEP 174

  Rat   212 AFDSPADVDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLA---- 272
            . :|....:|:||:|.|...||.|.||||||:.||.:|:.:..:....||..|.:|||.|.
  Fly   175 K-NSTFLPELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTVNGI 238

  Rat   273 ----AIEIQKAFATAFGVTVLAANIHHPTLGMTGSGIHTPLKSFWYH----------NMDDPEGH 323
                |::||..::.|..|.:|||....|.:|.:||||        ||          ..:..|..
  Fly   239 FSSKAVQIQLGWSYANNVNLLAAGASDPIVGNSGSGI--------YHGRSGSLRSVMRQESGERS 295

  Rat   324 LIIARVATNPQGLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHS 388
            :.:|||                  |.:|                .:.|.....|..:....:|:.
  Fly   296 IYVARV------------------PKYR----------------AKRRMKRDLKRQVATSSSFNI 326

  Rat   389 EMMY-DNFT---LVPVWGKEGHL--QVCSNSLCCHLLFERPALSKE-------LYALGVFDGLHT 440
            :..| :|||   |....||.|:|  .:|....|||......:|.|.       .|.:|:::|...
  Fly   327 KRDYLENFTSEELKIDAGKIGNLSQNLCHGGFCCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRN 391

  Rat   441 VH--GTYYVQACALVKCGGAGFETCGQEISEAE-GLFDF-HL-----WGNFSTLYVFPLFLTSGM 496
            ..  ...|::.|.:..|.|...:.|||.:.:.: .|..| |:     :.......:||..|...:
  Fly   392 EKRLDVNYIRNCGVFTCSGNSIDDCGQLLPDIQRPLVTFTHVEIRVTYPQSREFLLFPDTLLDNL 456

  Rat   497 TLDTPDQLGW------ESDH---YFLRKRGLSSGLVTAALYGRLY 532
            ....|.|..|      |..|   :.|||......|:|..:||..|
  Fly   457 LPLEPKQFEWSQKRISEESHQVRFALRKSLEVKHLLTFGIYGNYY 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btd	XP_006252671.1	biotinidase_like	50..353	CDD:143591	102/324 (31%)
Btd	XP_006252671.1	Vanin_C	385..535	CDD:408788	45/179 (25%)
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	105/362 (29%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	45/178 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351403
Domainoid	1	1.000	87	1.000	Domainoid score	I7801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37255
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9093
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	O	PTHR10609
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900