DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HCRTR2 and Hcrtr2

DIOPT Version :9

Sequence 1:	XP_016866287.1	Gene:	HCRTR2 / 3062	HGNCID:	4849	Length:	461	Species:	Homo sapiens
Sequence 2:	NP_037206.1	Gene:	Hcrtr2 / 25605	RGDID:	2788	Length:	460	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	432/461 - (93%)
Similarity:	442/461 - (95%)	Gaps:	1/461 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVF 65
            ||.||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVF 65

Human    66 VVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVI 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 VVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVI 130

Human   131 PYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECST 195
            ||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||.|:
  Rat   131 PYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSS 195

Human   196 VFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSS 260
            :.||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   196 MLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSS 260

Human   261 VVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNV 325
            |||||||..||||||||.||.:|:|:|||||||||||||||||||||:|||||||||||||||||
  Rat   261 VVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNV 325

Human   326 LKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQ 390
            ||||||||.|||||||||||||||||||||||||||||||||||||||||||||| ||||||.||
  Rat   326 LKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFS-CCLGVHRRQ 389

Human   391 EDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNWCLQQGPPSSLP 455
            .|||.|||||||||||||||||||||:|||||.|.|||||||||||||||||||.||||.||||.
  Rat   390 GDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLL 454

Human   456 STWLDV 461
            ||||:|
  Rat   455 STWLEV 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HCRTR2	XP_016866287.1	None
Hcrtr2	NP_037206.1	Required for response to orexin-A. /evidence=ECO:0000250\|UniProtKB:O43614	33..49		15/15 (100%)
		7tm_4	65..>185	CDD:304433	118/119 (99%)
		7tm_1	71..364	CDD:278431	277/292 (95%)
		Orexin_rec2	386..443	CDD:281778	50/56 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83697638
Domainoid	1	1.000	574	1.000	Domainoid score	I5293
eggNOG	1	0.900	-	-		E33208_3BIAU
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1168
Inparanoid	1	1.050	852	1.000	Inparanoid score	I6906
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47384
OrthoDB	1	1.010	-	-		D169415at32523
OrthoFinder	1	1.000	-	-		FOG0005211
OrthoInspector	1	1.000	-	-		oto138504
orthoMCL	1	0.900	-	-		OOG6_108762
Panther	1	1.100	-	-	LDO	PTHR24241
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270