DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment acvr1l and sax

DIOPT Version :9

Sequence 1:	NP_571420.1	Gene:	acvr1l / 30615	ZFINID:	ZDB-GENE-990415-9	Length:	506	Species:	Danio rerio
Sequence 2:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	264/468 - (56%)
Similarity:	327/468 - (69%)	Gaps:	31/468 - (6%)

- Green bases have known domain annotations that are detailed below.

Zfish    60 RGCLIGPASKRMTCSA------------TASASHVVECCSQHMCNANVSKETLLRLLLTSPEEKK 112
            |||...|....|.||.            |....:|| ||:...||.....|.|       |.:..
  Fly   118 RGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVV-CCAGDYCNEGDFPELL-------PFDSN 174

Zfish   113 TVHY------RVEMLVLFVLGPFVVLGLLSFLALLVCRRLHHGRL--ERLHEFDTEQGAIDG--L 167
            .|..      .:..:::.|||||:|:.||..:.:...||.|..||  .|..: |.|...::.  |
  Fly   175 DVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQ-DPEAYLVNDELL 238

Zfish   168 IASNVGDSTLADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVK 232
            .|::.|||||.:.:.||.|||||||||.|||||:|:|::|:||:|:|:|||||||.|.||::|||
  Fly   239 RATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVK 303

Zfish   233 IFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAV 297
            ||.||||:||.||||||:|:||||||||||:.||||||||.|||||:|||:..|||:|:|.|.|:
  Fly   304 IFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNAL 368

Zfish   298 EMADGLHMAASIASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAVTHTQSD 362
            ...|.:.:..|||:|||||||||||.:||||:||||||||||||..:..|.|||.||||||:...
  Fly   369 SHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVT 433

Zfish   363 NQLDVGNNPKVGTKRYMAPEVLDETIQTDCFDAYKRVDIWAFGLVLWEIARRTISNGIVEEYKPP 427
            .|||:|||||||||||||||||||:|..:||:|.:|.||:||||||||:.|||||.||.||||.|
  Fly   434 GQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVP 498

Zfish   428 FYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTL 492
            |||:||.||||:|||||||::..||.|||||.||..::.:.|||||||:|||..||.|||||||:
  Fly   499 FYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTI 563

Zfish   493 DKIHSSLEKGKTD 505
            .|:.|:.||.:.|
  Fly   564 HKLASADEKIRLD 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acvr1l	NP_571420.1	Activin_recp	28..94	CDD:307282	14/45 (31%)
		TGF_beta_GS	176..203	CDD:312125	18/26 (69%)
		STKc_ACVR1_ALK1	199..496	CDD:271044	205/296 (69%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	14/50 (28%)
		TM_EGFR-like	182..218	CDD:213052	11/35 (31%)
		TGF_beta_GS	247..274	CDD:285687	18/26 (69%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	205/296 (69%)
		TyrKc	276..553	CDD:197581	191/276 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	421	1.000	Domainoid score	I614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1300
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm26154
orthoMCL	1	0.900	-	-		OOG6_107567
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5088
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960