DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vsx1 and zen2

DIOPT Version :9

Sequence 1:	NP_571408.1	Gene:	vsx1 / 30598	ZFINID:	ZDB-GENE-990415-205	Length:	344	Species:	Danio rerio
Sequence 2:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	57/262 - (21%)
Similarity:	99/262 - (37%)	Gaps:	63/262 - (24%)

- Green bases have known domain annotations that are detailed below.

Zfish   111 RTESHFMQNLEQQRDVYSDDD-----CLSGDRNDGKNSGNSQKRKKRRHRTVFTSHQLEELEKAF 170
            ::|::|:.|       ||..|     |:..:......:......|.:|.||.|:|.||.|||:.|
  Fly     5 QSENYFVDN-------YSVSDLMMYPCVELNVEAAPTATTRSSEKSKRSRTAFSSLQLIELEREF 62

Zfish   171 NEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPL 235
            :...|.....|..::.:..|.|.::::||||||.|.:|...         ..|..||:.. ||||
  Fly    63 HLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTN---------RKGAIGALTT-SIPL 117

Zfish   236 P--------------ESIINSAKSGMMGSCAPWLLGEPAGMHKKSMEIVKKAPGTPESTHSD--- 283
            .              |.::..|.:.:          |.|.:.:....::::...||.....|
  Fly   118 SSQSSEDLQKDDQIVERLLRYANTNV----------ETAPLRQVDHGVLEEGQITPPYQSYDYLH 172

Zfish   284 TYSEEHKG------KDSDTTWSSGANGADDSEDMAIDLSSTSKQENKSTLKRSPPRTENSSDSEN 342
            .:|.|...      .:.|..|:|...|.:.:..:|.::...:.|:.        |..:|.....|
  Fly   173 EFSPEPMALPQLPFNEFDANWASSWLGLEPTIPIAENVIEHNTQDQ--------PMIQNFCWDSN 229

Zfish   343 ES 344
            .|
  Fly   230 SS 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vsx1	NP_571408.1	Octapeptide motif	37..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..70
		COG5576	101..>221	CDD:227863	31/114 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..156		6/33 (18%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:11331779	147..151		0/3 (0%)
		Homeobox	154..207	CDD:278475	21/52 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..344		14/79 (18%)
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	21/52 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910