DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pax7a and gsb-n

DIOPT Version :9

Sequence 1:	NP_571400.1	Gene:	pax7a / 30587	ZFINID:	ZDB-GENE-990415-201	Length:	507	Species:	Danio rerio
Sequence 2:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	211/460 - (45%)
Similarity:	259/460 - (56%)	Gaps:	101/460 - (21%)

- Green bases have known domain annotations that are detailed below.

Zfish    24 GFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILC 88
            |:|.:     |||||||||||||||||||||||.||||||..|:||||||||||||||||||||.
  Fly    15 GYPFQ-----GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILN 74

Zfish    89 RYQETGSIRPGAIGGSKPRQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRGTVPSGEA 153
            |||||||||||.||||||: |.:|::|.||:|.::|||.:||||||:||:|:|..|        .
  Fly    75 RYQETGSIRPGVIGGSKPK-VTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD--------P 130

Zfish   154 SSVSSISRVLRARFGKKDDDDECDKKDEDGEKKTKHSIDGILGDKGNRTDEGSDVESEPDLPLKR 218
            .|.|||||:||.          .|:..|||.|  .::|:|||   |.|..:.||.||||.:||||
  Fly   131 PSTSSISRLLRG----------SDRGSEDGRK--DYTINGIL---GGRDSDISDTESEPGIPLKR 180

Zfish   219 KQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQ 283
            |||||||||||||||.||:||.||.|||:||||||||.|.|||||:||||||||||.||.:|.:.
  Fly   181 KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSN 245

Zfish   284 --LAAFNH--------------LLPGGFPPTGMPTLPTYQLPESTYPSTTLSQDGSSTLHRPQPL 332
              |:..|.              ..|.|:.|.|:.::..|    |..|.||.:..|.:........
  Fly   246 SGLSPMNSGSSNVGVGVGLSGATAPLGYGPLGVGSMAGY----SPAPGTTATGAGMNDGVHHAAH 306

Zfish   333 PPSSMHQGGLSADSG------SAYGL--SSNRHTF-----------------SSYS----ETFMS 368
            .|||.|....:|.:.      ..|.|  |:.:|.|                 ..||    :.|..
  Fly   307 APSSHHSAATAAAAAHHHTQMGGYDLVQSAAQHGFPGGFAQPGHFGSQNYYHQDYSKLTIDDFSK 371

Zfish   369 PTASSNHMNPVSNGL---------------SPQVMSILSNPSAVPSQPQ-HDFSISPLHGGLEAS 417
            .||.|  ::.:|..|               |.......:|.:|..:|.| :|::.:..||
  Fly   372 LTADS--VSKISPSLHLSDNYSKLEAPSNWSQAAYHAAANYNAHVAQHQLNDYAAAAAHG----- 429

Zfish   418 NPISA 422
            ||.||
  Fly   430 NPASA 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pax7a	NP_571400.1	PAX	34..166	CDD:238076	95/131 (73%)
		Homeobox	223..276	CDD:278475	44/52 (85%)
		Pax7	343..386	CDD:289156	15/86 (17%)
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	93/129 (72%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	44/52 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm6578
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.020