DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hsp90ab1 and Gp93

DIOPT Version :9

Sequence 1:	NP_571385.2	Gene:	hsp90ab1 / 30573	ZFINID:	ZDB-GENE-990415-95	Length:	725	Species:	Danio rerio
Sequence 2:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	733	Identity:	333/733 - (45%)
Similarity:	483/733 - (65%)	Gaps:	30/733 - (4%)

- Green bases have known domain annotations that are detailed below.

Zfish     3 EEMRQEEEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELVSNASDALDKIRYESLTDPTKLDSG 67
            :|:|  |:|:.|.||.|:.::|.||||:.|.|||||||||:||||||:||||..:|::..:|::.
  Fly    66 KEIR--EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETN 128

Zfish    68 KDLKIDIIPNVQERTLTLIDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIG 126
            .:|.|.|..:.:.:.|.::|:|||||..||||||||||||||..|:..:|     .|.|:: |||
  Fly   129 PELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIG 193

Zfish   127 QFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVKVD-HGEPIGRGTKVILHLKEDQTE 190
            |||||||||:|||::|.|.||||||:||.|||.| .||::..| .|:.:.||:.:.|:|||:..:
  Fly   194 QFGVGFYSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQD 257

Zfish   191 YIEEKRVKEVVKKHSQFIGYPITLYVEKERDKEISDDEAEEEKAEKEEKEEEGEDKPKIEDVGSD 255
            ::||..|:|:::|:||||.:||.::..|..::|:..:  ||.|.||.|.:.|.|| .|:|:  ::
  Fly   258 FLEEDTVRELIRKYSQFINFPIRMWSSKTVEEEVPVE--EEAKPEKSEDDVEDED-AKVEE--AE 317

Zfish   256 DEEDTKDKDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDISNEEYGEFYKSLTNDWEDHLAVKHF 320
            ||       |.|.||:.:...|...:|.:||||||.|.:::.:||..||||||.|..:.|...||
  Fly   318 DE-------KPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHF 375

Zfish   321 SVEGQLEFRALLFIPRRAPFDLFEN-KKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSED 384
            ..||::.|::||::|:..|.:.|.. ..|.:|||||||||||.|...:::|.||:||||||||:|
  Fly   376 IAEGEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDD 440

Zfish   385 LPLNISREMLQQSKILKVIRKNIVKKCLELFAELAEDKDNYKKFYDAFSKNLKLGIHEDSQNRKK 449
            ||||:|||.|||.|::|||:|.:|:|.|::..::  ||:.|:||:..||.|:|||:.||..||.:
  Fly   441 LPLNVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSR 503

Zfish   450 LSELLRYQSSQSGDEMTSLTEYVSRMKENQKSIYYITGESKDQVAHSAFVERVCKRGFEVLYMTE 514
            |::|||:|:| :|..:|||.||..|||..|:.||||.|.::.:|..|.||||:..:|:||||:.|
  Fly   504 LAKLLRFQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVE 567

Zfish   515 PIDEYCVQQLKDFDGKSLVSVTKEGLELPEDEDEKKKMEEDKAKFENLCKLMKEI-LDKKVEKVT 578
            .:||||:..|.:||||...:|.|||.:|.|.|..||..|..|:.||.|.|.:.:: |..::.|..
  Fly   568 AVDEYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQ 632

Zfish   579 VSNRLVSSPCCIVTSTYGWTANMERIMKAQALR---DNSTMGYMMAKKHLEINPDHPIMETLRQK 640
            ||.||.:|||.:|...:|||.||||:..:.|.:   |.....|:..||.|||||.||:|..|.::
  Fly   633 VSERLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRR 697

Zfish   641 AEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDEDVPVEEPSSAAA 705
            .|||:.|...||:.:::|.||.|.||:.|.:....::.|.:|::..||:.:||.|..:|.....|
  Fly   698 VEADEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDA 762

Zfish   706 PEDIPPLEGDDDASRMEE 723
            .|.....:...:|...||
  Fly   763 EETATGSQESGNADDEEE 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hsp90ab1	NP_571385.2	PTZ00272	13..725	CDD:240341	329/723 (46%)
		HATPase_c	34..185	CDD:214643	85/157 (54%)
		HSP90	190..715	CDD:278607	228/529 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..269		16/48 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..725		9/33 (27%)
		TPR repeat-binding	721..725		2/3 (67%)
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	318/686 (46%)
		HATPase_c	97..216	CDD:238030	66/118 (56%)
		HSP90	257..748	CDD:278607	222/505 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720