Protein Alignment tcf7l1b and pan

DIOPT Version :9

• Sequence 1: NP_571371.2
• Gene: tcf7l1b / 30556
• ZFINID: ZDB-GENE-991110-10
• Length: 550
• Species: Danio rerio
• Sequence 2: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Alignment Length: 812
• Identity: 222/812 - (27%)
• Similarity: 303/812 - (37%)
• Gaps: 298/812 - (36%)

Zfish    11 ELGANDEMISFKDEGEQEDKISENVSAERDLDDVKSSLVNESE------------------NNSS 57
            :|.:|.|.:...|.....|.|.|.   :..|.|:|..|.|.|:                  ||.|
  Fly   243 KLKSNKEALDGYDLQHTCDFIREQ---KNILIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGS 304

Zfish    58 SSDSEQTERRPQPRADLESYEKARE--------------YFTEALRR-----QQDGCFFKSPHYP 103
            :|..|::.|| |...:.:|.|...|              |:..:|:|     ::||      .|.
  Fly   305 NSALEESVRR-QLNGNRKSIENLLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDG------EYT 362

Zfish   104 GYPFLMIPDLANPYLSNGALSPSARTYLQMKWP------------------------LLDVPGSA 144
            ..|...|..||...|||.::.|.....:..|.|                        :|.:..|.
  Fly   363 STPTHTIMALAAIALSNESILPQKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSV 427

Zfish   145 ALKDSQSPSPGH------------LSNKVPV-VQHA------HMHPLTP---------------- 174
            .:..|.|.|..|            .||..|. :.|:      |...:.|
  Fly   428 NMHQSSSASTPHESYSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSS 492

Zfish   175 --------LITYSNEFPPGTPPAHLSPE----------------ILDPK-----TGIPRTPHPAE 210
                    |:|.::.....|...:::.:                :.||.     :..|.||....
  Fly   493 SSNIETSRLLTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPLLVPEFSTAPSTPSTGS 557

Zfish   211 LSPYYPLSPGAVGQIPHPLGWLVPQQGQ----HMYPITAGGFR----------------HPYPAL 255
            .|   ..|.|.|..|   .|....::.|    |:..:|...|:                ...|::
  Fly   558 NS---GCSTGMVSGI---FGLSQNRRKQRLARHIETLTTNSFKSNAIRGNVDNEITNQLKTSPSI 616

Zfish   256 -----------------AMNASMSS---LVSSRFSPHLVPHHPH-GLHQTGIPHPAIVSPV---- 295
                             :.|||:::   .:::.|...|.....: |..:|.| .|.|.:|.
  Fly   617 RALPTENVSHLITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEI-FPMIDAPYDLSI 680

Zfish   296 --IKQEPNGELSPPVNTKSPGPNKKDED-KKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAIN 357
              ..:..|.|.....|.:|....:...| ||||||||||||||||||||||||||||||||||||
  Fly   681 GSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAIN 745

Zfish   358 QILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYG---KRKKRKRD-NKTDSTPEDF 418
            ||||||||.||||||:||||.||:|||||.:||||||||||||   |:||||:| :.|||...:.
  Fly   746 QILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNM 810

Zfish   419 S-----------------MRSKKPCVQYL-------PQE-------------------------- 433
            .                 .|.||.|::|:       |.|
  Fly   811 KKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDEDDYDDDKLG 875

Zfish   434 ---------------------KMIDSPGSSHG-SMLDSPATPSAALASPA---APAATH-----S 468
                                 :.:.|||...| |.|.||:| :.:||||.   |.:||:     |
  Fly   876 GSCGSADETNKIEDEDSESLNQSMPSPGCLSGLSSLQSPST-TMSLASPLNMNANSATNVIFPAS 939

Zfish   469 EQA-------QPLSLTTKPERFPLLSKPPPSSSSSSSSSSSGLPTPPLLSRPLPFALLTPP---S 523
            ..|       ||    |..:|..|:|    :|.|||.|:||...||...|...|...:|.|   |
  Fly   940 SNALLIVGADQP----TAQQRPTLVS----TSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLGS 996

Zfish   524 PFHQAAL----HSHHALFQSQP-LSLVTKSSD 550
            ...:|.:    .||..:..|.| :|..|..|:
  Fly   997 SQERAMMLGNRFSHLGMGLSPPVVSTSTSKSE 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tcf7l1b	NP_571371.2	CTNNB1_binding	1..231	CDD:285538	65/344 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		21/82 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..326		8/28 (29%)
		SOX-TCF_HMG-box	325..396	CDD:238684	64/70 (91%)
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	64/70 (91%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4951
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm25294
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.870