DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3a1 and Sf3a1

DIOPT Version :9

Sequence 1:	NP_001100705.1	Gene:	Sf3a1 / 305479	RGDID:	1311477	Length:	791	Species:	Rattus norvegicus
Sequence 2:	NP_650583.1	Gene:	Sf3a1 / 42048	FlyBaseID:	FBgn0266917	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	850	Identity:	433/850 - (50%)
Similarity:	546/850 - (64%)	Gaps:	139/850 - (16%)

- Green bases have known domain annotations that are detailed below.

  Rat    15 VVTEPKQPNEEEASSKEDSTPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNP 79
            :.|...:.|||:..:.:..:.|.|::|||||||||||||||||||||||||||||||||||:.||
  Fly     1 MATLDAEANEEQFGNDQPKSMSGPIIGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNELGNP 65

  Rat    80 KFNFLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQQQA---TQQQLPQKVQAQVIQETI 141
            ||||||..|||||||||||:||:||.    .|.|..:...:|.|   ..||..|::..||:::..
  Fly    66 KFNFLNGGDPYHAYYRHKVNEFREGN----DAGITALASMKQLAVTSAAQQRQQELLKQVVEQQF 126

  Rat   142 VPKEPPPEFEFIADPPSISAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFN 206
            ||||||||||||||||||||.|||:|||||||||||||||||.||.:||||:||||||||||||.
  Fly   127 VPKEPPPEFEFIADPPSISALDLDIVKLTAQFVARNGRQFLTNLMSREQRNFQFDFLRPQHSLFQ 191

  Rat   207 YFTKLVEQYTKILIPPKGLFAKLKKEAENPR----EVLDQVCYRVEWAKFQERERKKEEEEKEKE 267
            |||||:|||||:|||||.|..||:.|:...|    :||:||.||..|.:.||.:|::|||:.|:|
  Fly   192 YFTKLLEQYTKVLIPPKDLLGKLRSESAPGRSSMNQVLEQVKYRANWQRHQEAQRRREEEKIERE 256

  Rat   268 RVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEE 332
            |||||||||||||||||||:||.|.|||||||.|:|:|||:|::||.  ..|..:.||::|||:|
  Fly   257 RVAYAQIDWHDFVVVETVDYQPFESGNFPPPTNPDEVGARVLMEERL--MDEEGDTEMQIESDDE 319

  Rat   333 DQEKTEE------TPSQLD---------------------QDTQVQDMDEGSDDEEEGQKVPPPP 370
            ...:...      ..||::                     .:||||||||.|.||:.......|.
  Fly   320 GDSQANNLLDSGLKLSQMENRVGIQMKNVSSYGQPTGPKRDNTQVQDMDEASSDEDTPTTKLQPS 384

  Rat   371 ETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAP-DEYLVSPITGEKIPASKMQEHMRIGLLDP 434
            ..||   ||||.|:|:|:| |||||::| ..||.| ||||:||||||||||||:.||||||||||
  Fly   385 VAPM---LPPTHDKVVVKK-YDPKATQP-KQAPMPTDEYLISPITGEKIPASKVSEHMRIGLLDP 444

  Rat   435 RWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGV--EETAIGKKIGEEEIQKPEEK 497
            ||:||||:...||.:.|.|:|.|..||:|||||||||||||||  |||.||||:||||.:| :::
  Fly   445 RWVEQRDKHTVEKINQDNVFAAGTAIEASLKQLAERRTDIFGVGDEETVIGKKLGEEETKK-DDR 508

  Rat   498 VTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKP--NEIP-QQPPPPS 559
            ||||||:.|:....:||:|||||:|||..|||.|||:| |:.|||||| ||  |:.. ..||.||
  Fly   509 VTWDGHTSSVEAATRAARANITLEEQIHQIHKVKGLLP-DEEKEKIGP-KPVGNKATLSAPPQPS 571

  Rat   560 SATNIPSSA----------------------PPITSVP-------RPPAMPPPVRTTVVSAVPVM 595
            :.:....|:                      ||....|       .||..|.|| ..::...|.|
  Fly   572 TKSQHSHSSQSQHHQGGGGGHHGHHNPHHHHPPHQQAPPHQSHHHHPPQQPQPV-MQLMQLRPTM 635

  Rat   596 PRPPMAS----VVRLPPGSVIAPMPPIIHAPRINVVPMPPAAPPIMAPRPPPMIVPTAFVPAPPV 656
            .:||..:    .:.:.||.                                   :|....|||||
  Fly   636 MQPPFGAGGGGYMNMQPGG-----------------------------------IPQQIAPAPPV 665

  Rat   657 APVPAPAPMPPVHPPPPMEDEPPSKKLKTEDSLMPEEEFLRRNKGPVSIKVQVPNMQDKTEWKLN 721
                           ..||:||||||:::||:|:||.:|:..:|.||:|:|.||| .||:|||||
  Fly   666 ---------------DIMEEEPPSKKIRSEDNLIPEADFIATHKSPVTIQVLVPN-SDKSEWKLN 714

  Rat   722 GQGLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMASGAVIHLALKER 786
            ||.:..|:.|::.::.:|.|:.:.||||..|||:.|||:|.||||::|:||:.:|..:||.:|||
  Fly   715 GQMIAVTMALSEPIANLKTKLQDETGMPPAKQKIFYEGMFFKDSNTMAFYNLVNGTTVHLQVKER 779

  Rat   787 GGRKK 791
            |||||
  Fly   780 GGRKK 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3a1	NP_001100705.1	SWAP	50..103	CDD:197818	47/52 (90%)
		Surp	165..215	CDD:280053	42/49 (86%)
		PRP21_like_P	229..469	CDD:289034	140/271 (52%)
		SF3a120_C	716..791	CDD:176395	38/74 (51%)
		UBQ	716..784	CDD:214563	32/67 (48%)
Sf3a1	NP_650583.1	SWAP	36..89	CDD:197818	47/52 (90%)
		Surp	150..200	CDD:280053	42/49 (86%)
		PRP21_like_P	227..479	CDD:289034	156/281 (56%)
		SF3a120_C	709..784	CDD:176395	33/68 (49%)
		UBQ	713..777	CDD:214563	31/63 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349404
Domainoid	1	1.000	253	1.000	Domainoid score	I1994
eggNOG	1	0.900	-	-		E1_KOG0007
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4294
Inparanoid	1	1.050	772	1.000	Inparanoid score	I511
OMA	1	1.010	-	-		QHG55212
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	1	1.000	-	-		FOG0003484
OrthoInspector	1	1.000	-	-		oto97622
orthoMCL	1	0.900	-	-		OOG6_102246
Panther	1	1.100	-	-	LDO	PTHR15316
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3377
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770