DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pax3a and gsb-n

DIOPT Version :9

Sequence 1:	NP_571352.1	Gene:	pax3a / 30532	ZFINID:	ZDB-GENE-980526-52	Length:	509	Species:	Danio rerio
Sequence 2:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	217/491 - (44%)
Similarity:	266/491 - (54%)	Gaps:	119/491 - (24%)

- Green bases have known domain annotations that are detailed below.

Zfish    24 GYSLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILC 88
            ||..:     |||||||||||||||||||||||.||||||..|:||||||||||||||||||||.
  Fly    15 GYPFQ-----GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILN 74

Zfish    89 RYQETGSIRPGAIGGSKPKQSTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDGICDRNNVPSVSS 153
            |||||||||||.||||||| .|:|::|.:|:|.::|||.:||||||:||:|:|..|   .||.||
  Fly    75 RYQETGSIRPGVIGGSKPK-VTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD---PPSTSS 135

Zfish   154 ISRMLRCKFGGNGDEDEDDDEVEKREIEENERRAKHSIDGILGDRSSHSDEGSDVDSEPGLPLKR 218
            |||:||....|:.|..:|                 ::|:||||.|.|   :.||.:||||:||||
  Fly   136 ISRLLRGSDRGSEDGRKD-----------------YTINGILGGRDS---DISDTESEPGIPLKR 180

Zfish   219 KQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQ 283
            |||||||||||||||.|||||.||.|||:||||||||...|||||:||||||||||.||.:|.:.
  Fly   181 KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSN 245

Zfish   284 --LMAFNH--------------LIPGGFPPSAMSSLQPYQLADSPYPPSS---------ISQVSE 323
              |...|.              ..|.|:.|..:.|:..|    ||.|.::         :...:.
  Fly   246 SGLSPMNSGSSNVGVGVGLSGATAPLGYGPLGVGSMAGY----SPAPGTTATGAGMNDGVHHAAH 306

Zfish   324 QPSTVHRPQPLPPTSVHQSGLGSGPGAQEGSSAYCLSSGRHGFSGYSDGYVAAPGHANPVNPSIS 388
            .||:.|........:.|.:.:|.....|        |:.:|||.|   |: |.|||....|
  Fly   307 APSSHHSAATAAAAAHHHTQMGGYDLVQ--------SAAQHGFPG---GF-AQPGHFGSQN---- 355

Zfish   389 NGLPSQVMGLLNPGAVPHQPQSDFAL---SPLTGGLEPSTGMPASCHSS---QRLEALPGLPSMP 447
                           ..||..|...:   |.||.  :..:.:..|.|.|   .:|||
  Fly   356 ---------------YYHQDYSKLTIDDFSKLTA--DSVSKISPSLHLSDNYSKLEA-------- 395

Zfish   448 ALPSSQSYCPSSYSSPGYSV-----DHVASYQYSQY 478
                     ||::|...|..     .|||.:|.:.|
  Fly   396 ---------PSNWSQAAYHAAANYNAHVAQHQLNDY 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pax3a	NP_571352.1	PAX	34..159	CDD:128645	94/124 (76%)
		Homeobox	223..276	CDD:278475	44/52 (85%)
		Pax7	350..394	CDD:289156	12/43 (28%)
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	94/124 (76%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	44/52 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm6578
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4594
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.910