DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPIND1 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	377	Identity:	104/377 - (27%)
Similarity:	187/377 - (49%)	Gaps:	42/377 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   137 LYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF----KDFVNASSKYEITT 197
            :|::| .:.:|..|:.::||.|.|.:.|:.:|.:|.|.:::.|.|..    |:.|.|.
  Fly    21 IYQLL-SKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAAR------- 77

Human   198 IHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ-IADFSDPAFISK 261
                :..|.:.|..:..|..|:..|.:|:..|:.:..::...|||.:.:||: |:..:.|....:
  Fly    78 ----YGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAER 138

Human   262 TNNHIMKLTKGLIKDALENIDPAT-----QMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVV 321
            .|..::..|.|.||..   |||.:     :.:::|.|||||.|.:||....|....|::...:.|
  Fly   139 INQWVLDQTSGKIKGM---IDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSV 200

Human   322 KVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSM 385
            .|.||...|.|.|...::||..:::|.|: ..:||.|.:|.::.|:..||.::.     .:.:.:
  Fly   201 PVQMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEEKIV-----GFARPL 260

Human   386 TNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIA--IDLFKHQGTITVNEE 448
            ..:...:.|||||:|....|.|:|:.:|||.||....:::|:...:..  :....|:..:.||||
  Fly   261 VAKEVYLKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQVSHKAFLEVNEE 325

Human   449 GTQATTVTTVGFMPLSTQVRFT----VDRPFLFLIYEHRTSCLLFMGRVANP 496
            |.:|...|:|.   ::.:..|:    .|.||.|:|.:..|  :.|.|||.:|
  Fly   326 GAEAAGATSVA---VTNRAGFSTFLMADHPFAFVIRDANT--IYFQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	104/377 (28%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		2/19 (11%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	101/372 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020