DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppef2 and rdgC

DIOPT Version :9

Sequence 1:	XP_038947795.1	Gene:	Ppef2 / 305246	RGDID:	1307093	Length:	793	Species:	Rattus norvegicus
Sequence 2:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster

Alignment Length:	796	Identity:	295/796 - (37%)
Similarity:	419/796 - (52%)	Gaps:	149/796 - (18%)

- Green bases have known domain annotations that are detailed below.

  Rat    16 VSKPLPSLGSGSTVCPAGALCLSTMGSSSSTQ--------HHF-------AFQNAEKAFKAAALI 65
            |...:.:||....  |..:...::..:||..|        .||       :...|||..:||..|
  Fly    35 VGASMQTLGPNGQ--PQSSAAQTSTRASSLLQLFQRRGWCKHFRKPLRGMSASRAEKTIRAAIFI 97

  Rat    66 QRWYRRYMARLEMRRRCTWNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEE 130
            |:||||:.||.||:|||.|.|||::|||.:|||.:|::||:.|:.|...::..:..:........
  Fly    98 QKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSV 162

  Rat   131 RFAQDVETEEGGDFESIEVPDSYTGPRLSFPLLPDHATALVEAFRLRQ--QLHARYVLNLLYETR 193
            ...:|...||.||.         ...::..|:..:|...|::.||.::  :||.:||..:|.|..
  Fly   163 LDDKDDLVEEFGDI---------VNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAA 218

  Rat   194 RHLAQLPNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVEV 258
            :.|.|||||:.|||..|::|||||||||:||||:.:.:||||||....||||||||||||..:||
  Fly   219 KSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEV 283

  Rat   259 LMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLV 323
            |::|.:..|.:|....||||||||.::|.||||.:||..||..:.|:||..:.:|:.||||.:::
  Fly   284 LLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVL 348

  Rat   324 DEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENLEEQKRKDNQTSSAQKPTPWFLP 388
            :.:||::|||.||.|.|:|:..:||.|.||.:|
  Fly   349 NSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILR-------------------------------- 381

  Rat   389 QSRSLPSSPFHLGSGFKAYKACRSCSIPCGSAVSKELSRQGQVRRSMDLELELCRQQAGFLGIRE 453
                                       |
  Fly   382 ---------------------------P------------------------------------- 382

  Rat   454 KRESLPLADCDADAGGMLKPTPEEWKQVVDILWSDPMAQEGCKANTVRGGGCYFGPDVTEQLMEK 518
                 ||.|     |..|..|  ||:|:.||:||||.|..||..||:||.|.:||||||:..:::
  Fly   383 -----PLTD-----GEPLDKT--EWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQR 435

  Rat   519 YKLQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQY-QANKAT 582
            ::|.::||||||||.|:||.|:.|::|||||||||.:|||:|||::|...|.||.||| .|...|
  Fly   436 HRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQT 500

  Rat   583 HRLTMRQRISRVEESALRALRQKLFAHSSDLLVEFRKRDPDESGVITLSDWAVAVEAVLHLGLPW 647
            .||:.:||:..||.|||:.|..::..|..:|..||||.||.:||.|::|.|...:|.|..|||||
  Fly   501 KRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPW 565

  Rat   648 RMLRPQLVNSSADNVLEYKSWLDSLAKEQ-LSRENIQSSLLEKLYRNRSNLETIFRIIDSDHSGF 711
            |:||.:|...:....:.|...||.|..:. |..|....|:::.||.|:::|..||.|||:|:||.
  Fly   566 RLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGE 630

  Rat   712 ISLDEFRQTWKLFSSHMNIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVE----------- 765
            |:||||.....|..:||....:...:.:..|.:|.|.||.:|:|||||||||.:
  Fly   631 ITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSDLHRKEQQDENI 695

  Rat   766 QSCSEGQASACPQSTD 781
            :..|.|:.|....:||
  Fly   696 RRRSTGRPSVAKTATD 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppef2	XP_038947795.1	IQ	60..79	CDD:197470	11/18 (61%)
		MPP_RdgC	161..577	CDD:277364	165/418 (39%)
		FRQ1	617..761	CDD:227455	59/144 (41%)
		EFh	697..762	CDD:238008	29/64 (45%)
rdgC	NP_536738.3	IQ	89..111	CDD:197470	12/21 (57%)
		MPP_RdgC	184..494	CDD:277364	164/417 (39%)
		EFh	616..681	CDD:238008	29/64 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55959
Inparanoid	1	1.050	555	1.000	Inparanoid score	I1073
OMA	1	1.010	-	-		QHG59402
OrthoDB	1	1.010	-	-		D215218at33208
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105509
Panther	1	1.100	-	-	LDO	PTHR45668
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2939
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910