Protein Alignment tcf7l1a and pan

DIOPT Version :10

• Sequence 1: NP_571344.1
• Gene: tcf7l1a / 30523
• ZFINID: ZDB-GENE-980605-30
• Length: 560
• Species: Danio rerio
• Sequence 2: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Alignment Length: 780
• Identity: 186/780 - (23%)
• Similarity: 271/780 - (34%)
• Gaps: 289/780 - (37%)

Zfish    12 LGANDELISFKDEGEQEEKISENVSSERD-LDEVKSSLVNESE------------------NNSS 57
            |.:|.|.:    :|...:...:.:..::: |.::|..|.|.|:                  ||.|
  Fly   244 LKSNKEAL----DGYDLQHTCDFIREQKNILIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGS 304

Zfish    58 SSDSEQTDRRP--RPRPDLES-----------YEKQREYFAEALRR-----QQDGGFFKGPPYAG 104
            :|..|::.||.  ..|..:|:           :.....|:..:|:|     ::||      .|..
  Fly   305 NSALEESVRRQLNGNRKSIENLLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDG------EYTS 363

Zfish   105 YPFLMIPDITNPYLSNGSLSPSTRTYLQMKWP------------------------LLDVPASAA 145
            .|...|..:....|||.|:.|.....:..|.|                        :|.:.:|..
  Fly   364 TPTHTIMALAAIALSNESILPQKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVN 428

Zfish   146 LKDSRSPTPGH------------LSNKVP---------VVQHPHHVHPLTPLITYSNEHFSPGTP 189
            :..|.|.:..|            .||..|         ..:|...|.|.:.......|:.|..:.
  Fly   429 MHQSSSASTPHESYSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSS 493

Zfish   190 PSHLSPEILDPKTGIPRTPHPSELSPYYPL------SPGAVGQIPHPLGWLVPQQGQHMYSIPPG 248
            .:..:..:|...:.:........::...|:      ...|...:..||  |||:     :|..|.
  Fly   494 SNIETSRLLTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPL--LVPE-----FSTAPS 551

Zfish   249 GFRHPYPALAMNASMS------------------------SLVSSRFSPHMVPHPPHGLHQTGIP 289
                 .|:...|:..|                        :|.::.|..:.:    .|.....|.
  Fly   552 -----TPSTGSNSGCSTGMVSGIFGLSQNRRKQRLARHIETLTTNSFKSNAI----RGNVDNEIT 607

Zfish   290 HPAIVSPAIKQEP-------------------------------------NGESPSNSTHGKPSV 317
            :....||:|:..|                                     .|.:.|..|...|.:
  Fly   608 NQLKTSPSIRALPTENVSHLITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMI 672

Zfish   318 PV---------------------------KKE---EEKKPHIKKPLNAFMLYMKEMRAKVVAECT 352
            ..                           .||   ::||||||||||||||||||||||||||||
  Fly   673 DAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECT 737

Zfish   353 LKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYG---KRKKRKRD--- 411
            ||||||||||||||||.||||||:||||.||:|||||.:||||||||||||   |:||||:|
  Fly   738 LKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRST 802

Zfish   412 ----------CKS----DSPSESNFSPQPKKQCVPYL---------------------------- 434
                      |::    |..|:.....:.||:|:.|:
  Fly   803 TDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDED 867

Zfish   435 ---------------SSEKMCDSPTSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTK- 483
                           .:.|:.|..:.|....:.||...| .|:|..:|:.|.| .|.||::...
  Fly   868 DYDDDKLGGSCGSADETNKIEDEDSESLNQSMPSPGCLS-GLSSLQSPSTTMS-LASPLNMNANS 930

Zfish   484 ------------------PEGRAHHNHPHFPLPGKSSGSGSGSSMALHSLSRPIPFTSLPPSLLG 530
                              .:..|..........|.||||.|..|...::.|...|.|.:....||
  Fly   931 ATNVIFPASSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLG 995

Zfish   531  530
              Fly   996  995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tcf7l1a	NP_571344.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77		18/96 (19%)
		CTNNB1_binding	17..233	CDD:462440	49/303 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..328		10/97 (10%)
		HMG-box_TCF7-like	328..403	CDD:438812	68/74 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..513		44/199 (22%)
pan	NP_726528.2	HMG-box_TCF7-like	713..791	CDD:438812	70/77 (91%)