DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tcf7l1a and pan

DIOPT Version :9

Sequence 1:	NP_571344.1	Gene:	tcf7l1a / 30523	ZFINID:	ZDB-GENE-980605-30	Length:	560	Species:	Danio rerio
Sequence 2:	NP_726528.2	Gene:	pan / 43769	FlyBaseID:	FBgn0085432	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	186/780 - (23%)
Similarity:	271/780 - (34%)	Gaps:	289/780 - (37%)

- Green bases have known domain annotations that are detailed below.

Zfish    12 LGANDELISFKDEGEQEEKISENVSSERD-LDEVKSSLVNESE------------------NNSS 57
            |.:|.|.:    :|...:...:.:..::: |.::|..|.|.|:                  ||.|
  Fly   244 LKSNKEAL----DGYDLQHTCDFIREQKNILIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGS 304

Zfish    58 SSDSEQTDRRP--RPRPDLES-----------YEKQREYFAEALRR-----QQDGGFFKGPPYAG 104
            :|..|::.||.  ..|..:|:           :.....|:..:|:|     ::||      .|..
  Fly   305 NSALEESVRRQLNGNRKSIENLLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDG------EYTS 363

Zfish   105 YPFLMIPDITNPYLSNGSLSPSTRTYLQMKWP------------------------LLDVPASAA 145
            .|...|..:....|||.|:.|.....:..|.|                        :|.:.:|..
  Fly   364 TPTHTIMALAAIALSNESILPQKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVN 428

Zfish   146 LKDSRSPTPGH------------LSNKVP---------VVQHPHHVHPLTPLITYSNEHFSPGTP 189
            :..|.|.:..|            .||..|         ..:|...|.|.:.......|:.|..:.
  Fly   429 MHQSSSASTPHESYSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSS 493

Zfish   190 PSHLSPEILDPKTGIPRTPHPSELSPYYPL------SPGAVGQIPHPLGWLVPQQGQHMYSIPPG 248
            .:..:..:|...:.:........::...|:      ...|...:..||  |||:     :|..|.
  Fly   494 SNIETSRLLTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPL--LVPE-----FSTAPS 551

Zfish   249 GFRHPYPALAMNASMS------------------------SLVSSRFSPHMVPHPPHGLHQTGIP 289
                 .|:...|:..|                        :|.::.|..:.:    .|.....|.
  Fly   552 -----TPSTGSNSGCSTGMVSGIFGLSQNRRKQRLARHIETLTTNSFKSNAI----RGNVDNEIT 607

Zfish   290 HPAIVSPAIKQEP-------------------------------------NGESPSNSTHGKPSV 317
            :....||:|:..|                                     .|.:.|..|...|.:
  Fly   608 NQLKTSPSIRALPTENVSHLITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMI 672

Zfish   318 PV---------------------------KKE---EEKKPHIKKPLNAFMLYMKEMRAKVVAECT 352
            ..                           .||   ::||||||||||||||||||||||||||||
  Fly   673 DAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECT 737

Zfish   353 LKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYG---KRKKRKRD--- 411
            ||||||||||||||||.||||||:||||.||:|||||.:||||||||||||   |:||||:|
  Fly   738 LKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRST 802

Zfish   412 ----------CKS----DSPSESNFSPQPKKQCVPYL---------------------------- 434
                      |::    |..|:.....:.||:|:.|:
  Fly   803 TDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDED 867

Zfish   435 ---------------SSEKMCDSPTSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTK- 483
                           .:.|:.|..:.|....:.||...| .|:|..:|:.|.| .|.||::...
  Fly   868 DYDDDKLGGSCGSADETNKIEDEDSESLNQSMPSPGCLS-GLSSLQSPSTTMS-LASPLNMNANS 930

Zfish   484 ------------------PEGRAHHNHPHFPLPGKSSGSGSGSSMALHSLSRPIPFTSLPPSLLG 530
                              .:..|..........|.||||.|..|...::.|...|.|.:....||
  Fly   931 ATNVIFPASSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLG 995

Zfish 531 530
Fly 996 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tcf7l1a	NP_571344.1	CTNNB1_binding	1..233	CDD:285538	51/308 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77		18/96 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..328		10/97 (10%)
		SOX-TCF_HMG-box	328..399	CDD:238684	64/70 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..513		44/199 (22%)
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	64/70 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4951
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm25294
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.870