DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vtg3 and cv-d

DIOPT Version :9

Sequence 1:	NP_571340.1	Gene:	vtg3 / 30518	ZFINID:	ZDB-GENE-991019-2	Length:	1253	Species:	Danio rerio
Sequence 2:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster

Alignment Length:	1321	Identity:	258/1321 - (19%)
Similarity:	457/1321 - (34%)	Gaps:	358/1321 - (27%)

- Green bases have known domain annotations that are detailed below.

Zfish    24 LNSKKTYEYKYEGLVQV-------GRELPHLVESALKLRCTFKIIGESPHTFVLQVSNVDF---- 77
            ||.:..||  |||.|.|       |.:.|......::.:.|.:...|......|.:.:|..
  Fly    27 LNKQMLYE--YEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAALVIDDVTLNNSG 89

Zfish    78 EDFNGIPGKSVFSPSKNITKHLSAEISQPIIFEYSKGQITDIRTAPGVSNTVVNIVRGILGFLQV 142
            |.|  :..|.::.|.|.....|:.:           |.|:.:....|.....:|..|.|...||.
  Fly    90 EKF--LQNKEMYPPYKPFKIALTKD-----------GAISHVVFKEGDPIWSMNFKRAIASVLQF 141

Zfish   143 TVKTTQSFYELIELGIHGLCQSSYTVDEDSNAKELIVTRIVDITNCQQPASLYRGMALAPEDKLS 207
            .:|::.:|. :.||||||.|::.|.|...:|                     |..:...||.|..
  Fly   142 QMKSSGAFV-VDELGIHGTCRTEYFVSNRTN---------------------YISIRKTPEVKTC 184

Zfish   208 KQRGESVVSTVKHTYTVKSTADGG------QITKAFAQERQY-FSPFNVKGGNFRMLALRDIELL 265
            |...|:|       :|.:|.....      |.:.....|..| .||.|..|....|...:...|:
  Fly   185 KPYSEAV-------HTTRSNVPPNTCEFDHQKSVIIGNEAIYGMSPHNETGYYLSMAHAKGTTLI 242

Zfish   266 KVSDTTDKVVTGQVQSRGNLMYKTNKDLKPIPV-------------VMLNLNDPV----PK---- 309
            ...::|.:......:...|.:.:|..| .||.:             ..|:.|||.    |:
  Fly   243 HTFESTGEAQFINSELLLNFLNETPID-NPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQET 306

Zfish   310 -------ILDLIKRLAQANIYHVDSETSTEILDLIQLMRVTTLDNLEHLWKQVSGNDEHRRWFLD 367
                   :||.:....:...:.......:.:.|:|:|:.....|:|..|:::|.....:|:   :
  Fly   307 LIAQAGTLLDSLAEALETTEFKFSEPYDSTLSDVIKLLSEMDFDSLTKLYREVDIGTSYRQ---E 368

Zfish   368 LVVEVTDERILK-------FLEARYKAGDITANEAGQALVVAFN----HLSAEPVSVALAQEFLT 421
            .:..:..|.|.:       ||........:|..:....|::...    .||||  .|...::||.
  Fly   369 TIRNIFHEIIPRIGTKASVFLTHHLVLNKLTKPQIAVQLLIPMPFHIFELSAE--LVQKCEDFLN 431

Zfish   422 IPFSKSHPLLWNTVVLAYGSLVHRYCV-----------YTDPCPITVVQPLLNMAASSLSKNSED 475
            |  ....|.:....:|::.:|:|...|           |        ||...|   :.||....|
  Fly   432 I--GPDRPDVRQAAILSFATLIHNVYVAKGIDKEKFEEY--------VQKYFN---AYLSDRDFD 483

Zfish   476 EMVLALKSLGNAAHLSSFKTLLKFLPGYSNGAEKLSTRVQGAAVQAFRLLASRASHSVQDIVLNL 540
            :.:|.|:.|.| ..|.:....|:.:....|..|.|..:    |......||.|.:..:.::...:
  Fly   484 QKMLYLQGLNN-LQLGNVANYLEPIVQDPNEHEDLKFQ----AAWTTLALADRRAERIYEVYWPI 543

Zfish   541 FVQKHLPAEIRMLACIVLLETKPSTALISVVSEVLLEEADLQVASFSYSLLKGFAKSRTPDNQHL 605
            |..::...|:|:.|..:||.:.|:.|.:..:..::..|.|..:.::..:.:...:::..|..|||
  Fly   544 FESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISETTYPCYQHL 608

Zfish   606 SIACNIAMKILTRKLGHL------SYRYSKNLHFDWFHDDFLFGTSADVYMLQN-ESPIPTKLML 663
                   .::|:....||      .|..:.|..||:....|..|....|:::.: :|.:|.....
  Fly   609 -------RRLLSYMHRHLPQKPESRYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDMPVVAFF 666

Zfish   664 KGKFHFIGRILQFLEFGIRADGLKDLFAGKIPEL--TKDLGISDLASILKILS----NWQSL--- 719
            |.....:|:....|...|:|.||.|....|:...  :.......:.::|.:|.    |.:.|
  Fly   667 KFDTEALGKFTGQLALYIKARGLPDTILNKMQSRNGSDPFTFKSIKALLAMLQAPIINSKDLHLE 731

Zfish   720 ----PKDKPLLTAY--ARVFGQEAFLMDVSRDSVQSIIKSFSPSAGKESKVWERIQDVQKGTSWH 778
                .:.|.:|:.|  .|:|.|..:  |...:.:|.||::       :|.:  .:|.|:
  Fly   732 FILQMEGKTVLSYYLNQRMFRQLTY--DNILERMQQIIRT-------DSHI--NMQTVR------ 779

Zfish   779 WTKPHLVYEARFIQPTCLGLPVEISKYYSVVNAVTMKAKAEINPPPKEHLGEL---LSSDISMQT 840
            |.     :..|:..||.||...::....:|:.::......:.|.|..:|..|:   .||..|:::
  Fly   780 WP-----FMNRYTVPTVLGTSSDVLLQTTVLTSLRGNITEQRNSPITKHTLEIDARYSSYASVRS 839

Zfish   841 DGFIGVTKDHF--LFHGINTDLFQCGTELKSKVSMGLPWAFDLKINPK-EQTYEMNLTPSKSVTE 902
            ..:     :.|  |.|.||.:         ....:.:|::.:|.:|.. .:....:.:..:::|.
  Fly   840 RSY-----NPFLNLDHEINRE---------QGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTS 890

Zfish   903 LFSVSSNVYAVLRNIEDPTSSKITP----MMPETGE------SWQ----GVPLRMLPPLRDEQTK 953
            ..|..|......|.:...|::  .|    |:||...      |:.    ||.|.|...| :|..|
  Fly   891 GLSFKSRAVTKTRGLITKTAA--APFEEIMVPEGRNDVVQLFSYPMTDLGVRLSMTTNL-NELIK 952

Zfish   954 KSGMKFRQCAEAKIYGTALCIEAEAKRAHYLHEYPLYYLLGDTHFSYSLEPAKDAKPIEKIQIQV 1018
            ..||..:.......:...:.:.|            |.|:.|.|..|               .|.:
  Fly   953 YRGMLLKSEFTENGFSGNMVVNA------------LMYIFGFTQLS---------------SIHL 990

Zfish  1019 SASRQHPSVMSGMVNLNQRVFKETRDENTSCEERKTSSSLPVTQDLDVTPDPVVTVKALSLSPQA 1083
            ...|....:|     .|:   |.||.|...|.|           |:..|.|           .:.
  Fly   991 GHDRNFTMLM-----YNE---KNTRIEGNFCAE-----------DVLKTSD-----------MKG 1025

Zfish  1084 KPLGYEGVAFYLPTAQKDDIEMIVSEVGEEANWKMCANAHFDKTHTSAKAHLRWGAECQTYDVSM 1148
            |.:|.        |.:..|                    |.::.|.:...| ||       ::::
  Fly  1026 KQIGL--------TLEHTD--------------------HMNENHAADALH-RW-------NITL 1054

Zfish  1149 RVSAACQPESKPSISTKINWGTLPSVFTTVGQIVQE---------------YVPGV--------- 1189
            .|.|          |||.||      |...||:.:.               |.|.|
  Fly  1055 DVLA----------STKSNW------FKLTGQVQRNSKDDEDDWKACTKLTYEPLVFTKRPHTLN 1103

Zfish  1190 -SYIMGFYQKKEENPERQASV 1209
             ..:.|...::.|.||:.::|
  Fly  1104 GDVVFGLATEESECPEKGSTV 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vtg3	NP_571340.1	Vitellogenin_N	24..592	CDD:279663	129/635 (20%)
		DUF1943	626..912	CDD:286281	59/307 (19%)
		DUF1944	1070..1238	CDD:286284	27/165 (16%)
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	128/628 (20%)
		DUF1943	632..>813	CDD:286281	41/202 (20%)
		VWD	1277..1435	CDD:295339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581668
Domainoid	1	1.000	54	1.000	Domainoid score	I11190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950