DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ahr2 and ss

DIOPT Version :9

Sequence 1:	NP_571339.1	Gene:	ahr2 / 30517	ZFINID:	ZDB-GENE-990714-16	Length:	1027	Species:	Danio rerio
Sequence 2:	NP_001163629.2	Gene:	ss / 41988	FlyBaseID:	FBgn0003513	Length:	1015	Species:	Drosophila melanogaster

Alignment Length:	999	Identity:	284/999 - (28%)
Similarity:	431/999 - (43%)	Gaps:	261/999 - (26%)

- Green bases have known domain annotations that are detailed below.

Zfish     5 IGT-YAVKKRKKPVQKIPKPPPPDGV-KSNPSKRHRDRLNSELDKLTNLLPFSEDVRARLDKLSV 67
            :|| ||.|:|::..:.: ||||.||| |||||||||:|||:|||.|.:||||.:::.::||:||:
  Fly     4 LGTVYATKRRRRNGKSL-KPPPKDGVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSI 67

Zfish    68 LRLSVGYLKVKSFFNATI---KKTGG--------NGWLNDRSGTFGGNGQTASSLDGVNFSEGEL 121
            |||||.||:.||:|...:   |:..|        :|:.....|.|..           ...:|::
  Fly    68 LRLSVSYLRTKSYFQVVMHKDKEDNGVLPHIHAHDGYRTRELGAFEH-----------GLLDGDM 121

Zfish   122 LLQALNGFVLVVTAEGYVFYSSPTIQDYLGFHQSDVVHHSVFELIHTDDRAMFRRQLHFALNPSS 186
            .|||||||::::|.||.||:::.:|:.||||||||:||.||:||:|::||...:|||.:
  Fly   122 FLQALNGFLMILTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLW------ 180

Zfish   187 DSADGSEAMQSSSDITRDMVNYN-PQHIPPENSSFLERSFCCRFRCLLDNSSGFLALNFQGRLKY 250
                       :|.:..||.:.. .:.:.|:.:.:|||||..||||||||:||||.|:.:||:|.
  Fly   181 -----------NSFLPADMSSMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKV 234

Zfish   251 LHGQNKLAEDGTLAHPQLALFIIATPLQPPSILEIRSKTLLFQTKHKLDFTPMGIDTRGKVVLGY 315
            |||||:..|:     |.||||...||..|||:|||..|..:|::||||||:.:.:|.|||.:|||
  Fly   235 LHGQNRKTEE-----PPLALFAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGY 294

Zfish   316 TEIELCMRGSGYQFIHAADMMYCADNHIRMIKTGESGLTVFRLLSKGGTWIWVQANARLVYKAGR 380
            .:.||...| ||..:|..|:.|.|..|..::|||.||:..:|...|.|.|.|:|.::|||||..:
  Fly   295 ADAELVNMG-GYDLVHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSK 358

Zfish   381 PDFIIARQRALTNEEGEEHLRQRKLQLPFN-CATGEGVLYEVGPTLDVAEIQNQSKGQKMLNPPS 444
            |||:|...|.|.:|||.:.|.:|.:....: ..||....|             .|:..:::.|||
  Fly   359 PDFVICTHRQLMDEEGHDLLGKRTMDFKVSYLDTGLASTY-------------FSEADQLVVPPS 410

Zfish   445 LDPDSLLGSMLKQDHSLYSQNNDPNSQFTIDKAFGDSHALLNVPGNTWQPSTPNTVPGIKEEAVV 509
            ..|                                .:|||   |    .|.|| |.|..:.:..:
  Fly   411 TSP--------------------------------TAHAL---P----PPVTP-TRPNRRYKTQL 435

Zfish   510 KDMLETLQQIIEVGNNCNSLEDFNLDRMELKEWENTLCRMNYNNDMEINEIITEDIFSYVED--- 571
            :|.|.|          |.|       :.:|::......:.......::..........|:.|
  Fly   436 RDFLST----------CRS-------KRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYLPDPAA 483

Zfish   572 -VLFKENGIQPLKDLGPFSEMSEGLSELELQNNLAAN----------QEFSCQAGVHGGSPGQGG 625
             |....:.:.|:....|::..::   .|.:.:::.||          .::..|..|       ||
  Fly   484 AVAAAYSNLNPMYTTSPYASAAD---NLYMGSSMPANAFYPVSENLFHQYRLQGAV-------GG 538

Zfish   626 FIGMNIQEGMDTSSPGRGTVKLSHMGPQMLPGNNFIQSFGLDQTTQKMAGNSNILFRPSLAMQQS 690
            :.         |..|..|....:::      .|.|:...|.                 ::|.:..
  Fly   539 YY---------TDYPHSGAPASAYV------ANGFLSYDGY-----------------AIASKAD 571

Zfish   691 QQPNQVNLGLQGVVQENGIVPCGQRNLLTGNQPHPNTMTLPLQSPLVQGTSTQPMGFRNQNSLPQ 755
            ::           .||.|....|..:                             |:.:..|.||
  Fly   572 EK-----------WQETGKYYSGYSS-----------------------------GYGSPTSTPQ 596

Zfish   756 QPSISQNPQWVPSSNSVVDNRMNSCAHNVSGPQDAGLHSG-----PFANLQGQFSLHTQNAANAG 815
            |..: :.|:..|....|:     ||:.:...|......:|     |...|.|     |..||.||
  Fly   597 QIPL-KTPKSSPQVMEVI-----SCSSDGPSPVGGATPNGVGSVTPKVELAG-----TTAAAAAG 650

Zfish   816 PPGWQQ------SQPTPQGVPTSFSGGH----QPGFISQVTDFQRG--------TLNQMMPHTNG 862
            ...:::      ......|||.:..||.    .|....:.|....|        ..|.:.|.|..
  Fly   651 QDPYERQTVLMWGTTHSSGVPLNSHGGRTGAGNPASPQRSTPLGNGLGYASANNNNNDLEPATAA 715

Zfish   863 QGIGSGFLPKESASAIYPQ----QGD---FINNSPHKTSTSCMFMNNAQPSVNGMQYGSADLVSG 920
            :..|:..||.:|.||..|:    |.|   ..:.|.|.||.    ....|..:...|.|....||.
  Fly   716 KWNGTKELPGKSGSASTPESYQMQHDDSGLYSASSHTTSP----QQQQQQQLQQSQRGVGSNVSA 776

Zfish   921 MSSCQGTKGLLTQSPTQASCYFQR 944
            .||...:.|...|:...:||:.|:
  Fly   777 PSSSLTSTGTDQQAVHPSSCHQQQ 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ahr2	NP_571339.1	HLH	35..76	CDD:238036	25/40 (63%)
		PAS	118..232	CDD:279347	46/114 (40%)
		PAS	120..183	CDD:214512	33/62 (53%)
		PAS_11	292..396	CDD:291273	47/103 (46%)
		PAS	305..385	CDD:238075	36/79 (46%)
ss	NP_001163629.2	HLH	35..76	CDD:197674	25/40 (63%)
		PAS	123..178	CDD:214512	31/54 (57%)
		PAS_3	282..366	CDD:285623	37/84 (44%)
		PAS	<291..369	CDD:238075	34/78 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580934
Domainoid	1	1.000	105	1.000	Domainoid score	I6572
eggNOG	1	0.900	-	-		E1_KOG3560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004717
OrthoInspector	1	1.000	-	-		otm25417
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10649
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.800