DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ret and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_858048.2	Gene:	ret / 30512	ZFINID:	ZDB-GENE-980526-307	Length:	1106	Species:	Danio rerio
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	129/304 - (42%)
Similarity:	198/304 - (65%)	Gaps:	12/304 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish   708 KWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTLLK 772
            :|||||..|.....||||.||:|.:..|..:.|..|.||||||.|||:|:..:.:|||||..::|
  Fly   462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMK 526

Zfish   773 QVN-HPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDER 836
            .:. |.:|:.:.|.|:...|.::|:||...|.|:.:||.||  ...:.||...:::
  Fly   527 SLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR--AERHYGNTHGKSN--------- 580

Zfish   837 ALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRS 901
            .||..||.||.:|:::||.||....::||||||||:|:.:....|::|||.:|||.....|.::|
  Fly   581 VLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKS 645

Zfish   902 KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPE 966
            :|::|::|||.|||:|:|::.:||:||||:|:|||||||..|||||:...:...::.|||:||||
  Fly   646 EGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPE 710

Zfish   967 NCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDL 1010
            :|..|:||:|..||..:..:||.|::|.:.|:|::....||::|
  Fly   711 HCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIEL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ret	NP_858048.2	CA	186..256	CDD:214520
		PTKc_RET	715..1004	CDD:173631	121/289 (42%)
		Pkinase_Tyr	716..997	CDD:285015	119/281 (42%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	119/281 (42%)
		PTKc	474..742	CDD:270623	118/278 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810