DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tcf7l2 and Sox15

DIOPT Version :9

Sequence 1:	NP_571334.1	Gene:	tcf7l2 / 30510	ZFINID:	ZDB-GENE-991110-8	Length:	477	Species:	Danio rerio
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	351	Identity:	77/351 - (21%)
Similarity:	136/351 - (38%)	Gaps:	102/351 - (29%)

- Green bases have known domain annotations that are detailed below.

Zfish   169 QHPHHVHPLTPLITYSNEHFTPGNPPPHLQ--GDVDPKTGIPRPPHPPDISPYYPLSPGTVGQIP 231
            :||||:     |..|:::.:      ||:.  .:....||...|.|...:         |.|::.
  Fly     8 EHPHHL-----LTNYNSKKY------PHVSRTPEYSHSTGSDYPEHGGYL---------TDGRLM 52

Zfish   232 HPLG-----WLVPQQGQPVYP------ITTGGFRH----------------PYPTALTV----NA 265
            |...     :.|.|..:...|      |.:.|:.:                |.|...:.    ..
  Fly    53 HESNSDAGIYHVRQGSEHSSPSLHSPAIQSSGYENEHLNEAVLAAHSHSHSPMPMVSSAYVGGGT 117

Zfish   266 SMSSLLSSRFP-----PHMVPPHHSLHTTGIPHPAIV---TPNVKQESSHSDI-----------G 311
            :..||::|..|     .:.|......|    ||..:|   |..::..:|||.|           |
  Fly   118 ASGSLINSNIPLLGGGGNSVLNKFLSH----PHAGMVGGGTGQMEDCTSHSPIEAASMWSYDYKG 178

Zfish   312 SLNSS---------------KHQDAKKEEEKKKQPHIKKPLNAFMLYMKEMRAKVVAECTLKESA 361
            .|.:.               |::....:.:..|:..|::|:||||::.|..|.|:..|.....:|
  Fly   179 DLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNA 243

Zfish   362 AINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKQAGEGNEHRE 426
            .::::||::|.:|:.:::..|.|.|.:.|.:||..:|.:..|.. .:|:.:.|..|.| |.|..|
  Fly   244 DLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPR-RRKQSKLRAMQPG-GKEQSE 306

Zfish   427 YFP---------NPCLSLPPITDLSA 443
            ..|         ||.|:.||:...|:
  Fly   307 SSPNPGTGGSKSNPKLATPPLATASS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tcf7l2	NP_571334.1	CTNNB1_binding	17..236	CDD:285538	15/73 (21%)
tcf7l2	NP_571334.1	SOX-TCF_HMG-box	332..403	CDD:238684	22/70 (31%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	22/70 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	58	1.000	Inparanoid score	I5417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.050