DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egr1 and odd

DIOPT Version :9

Sequence 1:	NP_571323.1	Gene:	egr1 / 30498	ZFINID:	ZDB-GENE-980526-320	Length:	511	Species:	Danio rerio
Sequence 2:	NP_722922.1	Gene:	odd / 33583	FlyBaseID:	FBgn0002985	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	90/382 - (23%)
Similarity:	134/382 - (35%)	Gaps:	96/382 - (25%)

- Green bases have known domain annotations that are detailed below.

Zfish   148 SSTSSIPSSSSSSTSSASLSCSVHQSEPNPIYSAAPTYSSASPDIFPESGPNFSTTVGTSLQYSS 212
            ||||:.|.|:.:.....:||.....:|.:.|.......:|.||.:.|...|
  Fly     2 SSTSASPISNITVDDELNLSREQDFAEEDFIVIKEERETSLSPMLTPPHTP-------------- 52

Zfish   213 STYPSAKTCNPSFSVPMIPDYLF--------------TQQQSEISLVPPDQKPIQTQAGQQPALT 263
             |....:..:|:.|...:...|.              .|||.....:...|:..|.||.||..:.
  Fly    53 -TEEPLRRVHPAISEEAVATQLHMRHMAHYQQQQQQQQQQQQHRLWLQMQQQQQQHQAPQQYPVY 116

Zfish   264 PLHTIKAFATQTGSQDL-------KSVYQSQLIKPSRMRK-----YPNRPSKTPPHERPY----- 311
            |..:....|..   |.|       .::||.|..:......     :|:.|...|.|.|||
  Fly   117 PTASADPVAVH---QQLMNHWIRNAAIYQQQQQQQQHPHHHHHHGHPHHPHPHPHHVRPYPAGLH 178

Zfish   312 ------------ACPV----------------------------ETCDRRFSRSDELTRHIRIHT 336
                        |.|.                            :.|:|:|::|..|..|.|.||
  Fly   179 SLHAAVMGRHFGAMPTLKLGGAGGASGVPSGATGSSRPKKQFICKYCNRQFTKSYNLLIHERTHT 243

Zfish   337 GQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHMRQKDKKA-- 399
            .::|:.|.||.:.|.|.|||..|...|:.:|||.|..||:.|.:|.....|...|:.:...|.
  Fly   244 DERPYSCDICGKAFRRQDHLRDHRYIHSKDKPFKCSDCGKGFCQSRTLAVHKVTHLEEGPHKCPI 308

Zfish   400 ---EKGATAAVQSSVSNISISASSPVSSYPSPITSY--PSPVSSFPSPVNSCYSSPV 451
               .....|.::|.:.:.|..::..|....||.||:  |:...|.|.|.|.....||
  Fly   309 CQRSFNQRANLKSHLQSHSEQSTKEVVVTTSPATSHSVPNQALSSPQPENLAQHLPV 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egr1	NP_571323.1	DUF3446	99..185	CDD:288757	10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..169		8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..312		7/42 (17%)
		zf-C2H2	311..335	CDD:278523	10/68 (15%)
		C2H2 Zn finger	313..335	CDD:275368	8/49 (16%)
		zf-H2C2_2	327..352	CDD:290200	10/24 (42%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		zf-H2C2_2	355..380	CDD:290200	11/24 (46%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..406		3/26 (12%)
		DUF3432	403..498	CDD:288743	15/51 (29%)
odd	NP_722922.1	COG5048	<203..334	CDD:227381	34/130 (26%)
		C2H2 Zn finger	222..242	CDD:275368	7/19 (37%)
		zf-H2C2_2	234..259	CDD:290200	10/24 (42%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		zf-H2C2_2	262..285	CDD:290200	10/22 (45%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		zf-C2H2	304..326	CDD:278523	3/21 (14%)
		C2H2 Zn finger	306..326	CDD:275368	2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940