DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egr1 and cbt

DIOPT Version :9

Sequence 1:	NP_571323.1	Gene:	egr1 / 30498	ZFINID:	ZDB-GENE-980526-320	Length:	511	Species:	Danio rerio
Sequence 2:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	98/374 - (26%)
Similarity:	146/374 - (39%)	Gaps:	102/374 - (27%)

- Green bases have known domain annotations that are detailed below.

Zfish   124 GLVGINP-------PPASIPSSTSQATHPSSS-------------------------STSSIPSS 156
            |::..||       |..::|:...:...|:.|                         |:.::.||
  Fly    52 GIITPNPSDTEDEAPEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSS 116

Zfish   157 SSSSTSSASLSCSVHQSEPNPIYSAAPTYSSASPDIFPESGPNFSTTVGTSLQYSSSTYPSAKTC 221
            |....||:|.||....|..|...|:.|   ....|.:||:      .|..:|::..:...:|:..
  Fly   117 SQDENSSSSTSCCSSSSNTNTSTSSVP---PTVEDDYPEA------NVWRNLKFKMNRKRAAEVA 172

Zfish   222 NPSFSVPMIPDYLFTQQQSEISLV-PPDQKPIQTQAGQQPALTPLHTIKAFATQTGSQDLKSVYQ 285
            .|....|..|         ...|| ||.......:...:|.|||::.         |....|..|
  Fly   173 LPPVQTPETP---------VAKLVTPPAPAECIKEEEIKPILTPIYV---------SPVASSASQ 219

Zfish   286 SQLIKPSRMRKYPNRPSKTP------------------PHERPYACPVETCDRRFSRSDELTRHI 332
            ..|:.....::.|....|||                  ...|.|.|....|.:.:.:|..|..|.
  Fly   220 LILLSTVAAQQSPTPVPKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQ 284

Zfish   333 RIHTGQKPFQCR--ICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHMRQK 395
            |:|||::||.|:  .|.:.|||||.|:.|.|||||||.|.|.:|.:||.|||...:|.|.|  .|
  Fly   285 RVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH--NK 347

Zfish   396 DKK---------AEKGATAAVQSSVSNISI-----------SASSPVSS 424
            ||.         |....:|:|.:|:.:.|:           ::|||:||
  Fly   348 DKANGVNRHVSLANNNTSASVAASLCDASLHLRAIAPAGSSASSSPISS 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egr1	NP_571323.1	DUF3446	99..185	CDD:288757	20/92 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..169		11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..312		5/38 (13%)
		zf-C2H2	311..335	CDD:278523	7/23 (30%)
		C2H2 Zn finger	313..335	CDD:275368	6/21 (29%)
		zf-H2C2_2	327..352	CDD:290200	11/26 (42%)
		C2H2 Zn finger	343..363	CDD:275368	10/21 (48%)
		zf-H2C2_2	355..380	CDD:290200	14/24 (58%)
		C2H2 Zn finger	371..391	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..406		7/30 (23%)
		DUF3432	403..498	CDD:288743	9/33 (27%)
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	7/23 (30%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	41/93 (44%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940