Protein Alignment c3a.2 and Tep1

DIOPT Version :10

• Sequence 1: NP_571318.1
• Gene: c3a.2 / 30491
• ZFINID: ZDB-GENE-990415-36
• Length: 1651
• Species: Danio rerio
• Sequence 2: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Alignment Length: 1621
• Identity: 396/1621 - (24%)
• Similarity: 667/1621 - (41%)
• Gaps: 400/1621 - (24%)

Zfish     6 LFLSAVLLSSALLTLCDPLYVLMAPNLLRVGSSENVFVEAQDYSGEPLRVKISVKNFPAKNVEMM 70
            |.||:.:|...||:..:.||.::||..||..|:.||.|              ::.|    .....
  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVV--------------AIHN----TTRTT 50

Zfish    71 QKTVTLTG-----EKYQILTDIEIPDDKNFFSDDEKKQYVYLQAHFPSVT---LEKVVM----VS 123
            :.:|:|||     .||   .|::....|:...|            .|.:|   .|..||    :.
  Fly    51 EVSVSLTGPSLNSRKY---VDVQSMSSKSVRFD------------IPKLTEGDYELKVMGSGGIE 100

Zfish   124 FQS----------GYLFVQTDKPIYTPGSNVQYRIFSMTPNLKP--LSQPGITVDIMN-PQGITV 175
            ||:          .:|::|:||..|.||..:|:|:..:..|.:|  :.:| |.::|.: .|.:..
  Fly   101 FQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKP-IKIEIRDGDQNLIK 164

Zfish   176 ASDAIKAEKGVKSSIYNIPDVTSLGMWKVVT------RYTNTPLKTFTAEFEVKEYVLPTFE-VK 233
            :...||..|||.|....:.|...||.|.|..      :.||.        ..|.:||:|.|| |.
  Fly   165 SWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNV--------LVVDKYVVPKFEVVV 221

Zfish   234 LTPSSFFYYVGDNKQENDEEDSLTVDIEAKYLFGKKMDGNAFVVFGVMDGAAKTSIVNSLQKVPV 298
            ||..:.....|          .:...|:|:|.|.|.:.|:   |...::|:      ::.|.:|
  Fly   222 LTAKNVAASAG----------YIRATIKARYTFKKPVKGH---VVATIEGS------STEQSLP- 266

Zfish   299 VNGVGTAELTREMITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKRT 363
            ::|....|..   |:.|.|.:..:..        ::||   |:.:.:..|    |:..|:|..|.
  Fly   267 IDGEVNVEFP---ISATAKRLLKITA--------IVTE---ELTDIKHNG----TAYVTVHQHRH 313

Zfish   364 S-------QFFKPGMPLGVSVYVTNPDETPAKD----VEVEVLVDGKGGVSGKTRDNGIAKVKVN 417
            .       ..::||:.......|.|.|.:|..|    |...||..........:..|.||...:.
  Fly   314 KLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIM 378

Zfish   418 TPGGASTLKITAKTKNTEYTSEQQAVKTMTAQAYKTKHDSKNYLH-------INIESAEFEIGDQ 475
            .|....:..:|:                    .:.|..:.:.|::       |.|.:.:.::...
  Fly   379 LPETCQSCLVTS--------------------TFDTAENIERYIYKLNKPLMIAINTKKPQLRKL 423

Zfish   476 MTVNLITGQSSGDRDQDYTYMIL---SKGQIVLA----ERFKRQGQTLVTLSLTITKEMVPSFRF 533
            :.:|:|:       |....|.||   ::|.|||:    .:.|::.|.:         |..|:|..
  Fly   424 LKINIIS-------DTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI---------EFEPTFAL 472

Zfish   534 V----AYYHVGKDEV-VSDSVWVDVKDTCMGKLNVEVKEKKNTYE--TGN------DVNLHITGD 585
            |    .:.|...|.| :||...||::           ::.:||.|  |.|      :|:|.:..:
  Fly   473 VPQATIFVHYIIDGVLMSDEKTVDIE-----------RDFENTIEILTTNEALPRDEVSLKVKTN 526

Zfish   586 PGARVGLVVVDKAVQVLNK-NRLTQSKVWDVIEKHDTGCTGGGGKDSMGVFSDAGL-IFESNTAG 648
            |.:.|||:.||::|.:|.. |.|.:..:.:.:..:.|         .:.:.::|.: |:.|  :|
  Fly   527 PHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYST---------DLVILTNANINIYRS--SG 580

Zfish   649 GTDTRTVPECPAPLKRKRRSESLQTITTTLAGQYTEKIRPCCYDGMRNNRIGYTCERRASYVIDG 713
            |                                        ||     ...|||
  Fly   581 G----------------------------------------CY-----TNPGYT----------- 589

Zfish   714 EECVKAFLHCCKEVKNHKEKETEEEELILARSDEDEEGDYKDYDDITS-RTQFPESWLWEEF-DL 776
             .|..:.:.... .||...|.:....::         |..:....:.. |..|||:||:... |:
  Fly   590 -NCTGSLIGRTM-FKNEPTKNSGPVPIV---------GSTRAQASLPPVRKLFPETWLFSNITDV 643

Zfish   777 CDKCSKPSKDKVIYLKDSITTWQILAISLSPTHGICVA-EPEEIVVFKSFFIDLKVPYSAVRGEQ 840
            ........|:.|   .|::|:|.|...||||..|:.|. .|..|.||:.|||...:|||..|||.
  Fly   644 GANGEYIIKETV---PDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEV 705

Zfish   841 VEIKAIIHNYTPKHLK-KV-------RVEFLETAGVCSAASKKG-KYRTTVNVDKDSSVAVSFVI 896
            :.|..|:.||....:| ||       :.||:||.....:...:| :.:.|:.:..::...:||:|
  Fly   706 IAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMI 770

Zfish   897 VPMTLESQHIEVKASISDYE-DGVRKTLKVVSEGV---------LTKFRTEKLELNPGKKGEKPL 951
            .|..:....:::.| ||.|. |.:.:.|||.::||         :...|..:..|.|   .||.:
  Fly   771 RPKKVGLTTLKITA-ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAP---PEKTI 831

Zfish   952 VLRSGIPADQVPGTPVNSYITVTGEEISQSIEQAINGSFMGELIIQPHGCGEQNMVTMTLPFIAT 1016
            ::..   ||.|    :....||..|....|  ||.....:.:|:..|.|||||||.......:|.
  Fly   832 IIEK---ADNV----IEGSETVEFEVCGTS--QAPQLEHLDDLVHLPCGCGEQNMFNFVPSILAL 887

Zfish  1017 HYLDNTNQWEYVGIDRRKVAINHIKTGYEGQLKFRKQDGSYALWIETDS--STWLTAYVAKVFAM 1079
            .||...|:.:.   :....|..:::|||:.:|.:::.|||::.|.:.|:  ||||||||.:.|..
  Fly   888 SYLKAKNRQDQ---EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQ 949

Zfish  1080 ASKLIAIEENVICSALKWLVMHKQLPDGSFKEDKPVYHREIMGGIEGQNTDVSLTAFVLIAMQEG 1144
            |:|.|.|::||:.:.|.:|| .:|..||.|||...|.|       ....:.::||:|||:...|.
  Fly   950 AAKYIDIDKNVLVAGLDFLV-SRQSTDGKFKELGMVIH-------NSHGSPLALTSFVLLTFFEN 1006

Zfish  1145 KEICGGAVGSLHESIRKSVAFLKNQLTKLTNPYAAALTSYALANADS------LDKEILMKHSTK 1203
            :|.    :......|.::|.|:..::.:...||..|:.:.||:.|.:      |||  |.|.:|:
  Fly  1007 EEY----MPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDK--LDKLATR 1065

Zfish  1204 GNDGRFWNVPGWHYHS-IEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVFQ 1267
            ..|.::|........| :|.|:|.:|||::....|.....|.||..:::|:||:.::|.|::...
  Fly  1066 RGDHKWWTGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIM 1130

Zfish  1268 AVAEYRAQVQ------DLKNFDLNVELVVPGRRKTDRWTIQRSNVHLTRSGSV--------DMNK 1318
            |:.:|..|..      |::.:.||.:               :.:|.:|:....        :...
  Fly  1131 ALTKYELQSHASTEAIDIEFWHLNED---------------KKHVRVTKENEFKVQTHQLPENTN 1180

Zfish  1319 DFTVIAKGTGSAILSVLTLYY------ARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTYNFILD 1377
            :..::|||.|.|.:. ||..|      |||..|.|      .:||.........|..|||..|.
  Fly  1181 EVKLLAKGQGRAQVQ-LTYRYNVATKEARPSFKLT------TTVKKSHKGRLILGICGTYTPIA- 1237

Zfish  1378 FFYKNKTNDATMTILDIGLPTGF--DIDE-ADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLNK 1439
            ...:|||.:  |.::.:.||:|:  ||:. ||::.:|..| |...|.|..:|       .||..|
  Fly  1238 ASERNKTTN--MALMQVQLPSGYVCDIEPFADIEAISDVK-RVETKNEDTEV-------HIYFEK 1292

Zfish  1440 VSHKESETLVFRMHKTFNVGLLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLC 1500
            :|..:.:.|......|..|..|:|:.|.:|:||:.:....::||   .|::|..:|.|:.|
  Fly  1293 LSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYH---VDTSLCDICHGNEC 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c3a.2	NP_571318.1	MG1	22..123	CDD:465508	25/112 (22%)
		YfaS	<127..1339	CDD:441940	313/1306 (24%)
		A2M	768..862	CDD:459711	35/103 (34%)
		complement_C3_C4_C5	987..1272	CDD:239226	90/293 (31%)
		A2M_recep	1385..1483	CDD:462226	27/100 (27%)
		NTR_complement_C3	1502..1649	CDD:239638
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	312/1303 (24%)
		A2M_2	859..1135	CDD:239227	90/292 (31%)
		A2M_recep	1243..1336	CDD:462226	29/102 (28%)