DRSC/TRiP Functional Genomics Resources

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Protein Alignment c3a.2 and Tep1

DIOPT Version :9

Sequence 1:NP_571318.1 Gene:c3a.2 / 30491 ZFINID:ZDB-GENE-990415-36 Length:1651 Species:Danio rerio
Sequence 2:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster


Alignment Length:1622 Identity:396/1622 - (24%)
Similarity:667/1622 - (41%) Gaps:402/1622 - (24%)


- Green bases have known domain annotations that are detailed below.


Zfish     6 LFLSAVLLSSALLTLCDPLYVLMAPNLLRVGSSENVFVEAQDYSGEPLRVKISVKNFPAKNVEMM 70
            |.||:.:|...||:..:.||.::||..||..|:.||.|              ::.|    .....
  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVV--------------AIHN----TTRTT 50

Zfish    71 QKTVTLTG-----EKYQILTDIEIPDDKNFFSDDEKKQYVYLQAHFPSVT---LEKVVM----VS 123
            :.:|:|||     .||   .|::....|:...|            .|.:|   .|..||    :.
  Fly    51 EVSVSLTGPSLNSRKY---VDVQSMSSKSVRFD------------IPKLTEGDYELKVMGSGGIE 100

Zfish   124 FQS----------GYLFVQTDKPIYTPGSNVQYRIFSMTPNLKP--LSQPGITVDIMN-PQGITV 175
            ||:          .:|::|:||..|.||..:|:|:..:..|.:|  :.:| |.::|.: .|.:..
  Fly   101 FQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKP-IKIEIRDGDQNLIK 164

Zfish   176 ASDAIKAEKGVKSSIYNIPDVTSLGMWKVVT------RYTNTPLKTFTAEFEVKEYVLPTFE-VK 233
            :...||..|||.|....:.|...||.|.|..      :.||.        ..|.:||:|.|| |.
  Fly   165 SWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNV--------LVVDKYVVPKFEVVV 221

Zfish   234 LTPSSFFYYVGDNKQENDEEDSLTVDIEAKYLFGKKMDGNAFVVFGVMDGAAKTSIVNSLQKVPV 298
            ||..:.....|          .:...|:|:|.|.|.:.|:   |...::|:      ::.|.:|:
  Fly   222 LTAKNVAASAG----------YIRATIKARYTFKKPVKGH---VVATIEGS------STEQSLPI 267

Zfish   299 VNGVGTAELTREM-ITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKR 362
                 ..|:..|. |:.|.|.:..:..        ::||   |:.:.:..|    |:..|:|..|
  Fly   268 -----DGEVNVEFPISATAKRLLKITA--------IVTE---ELTDIKHNG----TAYVTVHQHR 312

Zfish   363 TS-------QFFKPGMPLGVSVYVTNPDETPAKD----VEVEVLVDGKGGVSGKTRDNGIAKVKV 416
            ..       ..::||:.......|.|.|.:|..|    |...||..........:..|.||...:
  Fly   313 HKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHI 377

Zfish   417 NTPGGASTLKITAKTKNTEYTSEQQAVKTMTAQAYKTKHDSKNYLH-------INIESAEFEIGD 474
            ..|....:..:|:                    .:.|..:.:.|::       |.|.:.:.::..
  Fly   378 MLPETCQSCLVTS--------------------TFDTAENIERYIYKLNKPLMIAINTKKPQLRK 422

Zfish   475 QMTVNLITGQSSGDRDQDYTYMIL---SKGQIVLA----ERFKRQGQTLVTLSLTITKEMVPSFR 532
            .:.:|:|:       |....|.||   ::|.|||:    .:.|::.|.:         |..|:|.
  Fly   423 LLKINIIS-------DTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI---------EFEPTFA 471

Zfish   533 FV----AYYHVGKDEV-VSDSVWVDVKDTCMGKLNVEVKEKKNTYE--TGN------DVNLHITG 584
            .|    .:.|...|.| :||...||::           ::.:||.|  |.|      :|:|.:..
  Fly   472 LVPQATIFVHYIIDGVLMSDEKTVDIE-----------RDFENTIEILTTNEALPRDEVSLKVKT 525

Zfish   585 DPGARVGLVVVDKAVQVLNK-NRLTQSKVWDVIEKHDTGCTGGGGKDSMGVFSDAGL-IFESNTA 647
            :|.:.|||:.||::|.:|.. |.|.:..:.:.:..:.|         .:.:.::|.: |:.|  :
  Fly   526 NPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYST---------DLVILTNANINIYRS--S 579

Zfish   648 GGTDTRTVPECPAPLKRKRRSESLQTITTTLAGQYTEKIRPCCYDGMRNNRIGYTCERRASYVID 712
            ||                                        ||     ...|||          
  Fly   580 GG----------------------------------------CY-----TNPGYT---------- 589

Zfish   713 GEECVKAFLHCCKEVKNHKEKETEEEELILARSDEDEEGDYKDYDDITS-RTQFPESWLWEEF-D 775
              .|..:.:.... .||...|.:....::         |..:....:.. |..|||:||:... |
  Fly   590 --NCTGSLIGRTM-FKNEPTKNSGPVPIV---------GSTRAQASLPPVRKLFPETWLFSNITD 642

Zfish   776 LCDKCSKPSKDKVIYLKDSITTWQILAISLSPTHGICVA-EPEEIVVFKSFFIDLKVPYSAVRGE 839
            :........|:.|   .|::|:|.|...||||..|:.|. .|..|.||:.|||...:|||..|||
  Fly   643 VGANGEYIIKETV---PDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGE 704

Zfish   840 QVEIKAIIHNYTPKHLK-KV-------RVEFLETAGVCSAASKKG-KYRTTVNVDKDSSVAVSFV 895
            .:.|..|:.||....:| ||       :.||:||.....:...:| :.:.|:.:..::...:||:
  Fly   705 VIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFM 769

Zfish   896 IVPMTLESQHIEVKASISDYE-DGVRKTLKVVSEGV---------LTKFRTEKLELNPGKKGEKP 950
            |.|..:....:::.| ||.|. |.:.:.|||.::||         :...|..:..|.|   .||.
  Fly   770 IRPKKVGLTTLKITA-ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAP---PEKT 830

Zfish   951 LVLRSGIPADQVPGTPVNSYITVTGEEISQSIEQAINGSFMGELIIQPHGCGEQNMVTMTLPFIA 1015
            :::..   ||.|    :....||..|....|  ||.....:.:|:..|.|||||||.......:|
  Fly   831 IIIEK---ADNV----IEGSETVEFEVCGTS--QAPQLEHLDDLVHLPCGCGEQNMFNFVPSILA 886

Zfish  1016 THYLDNTNQWEYVGIDRRKVAINHIKTGYEGQLKFRKQDGSYALWIETDS--STWLTAYVAKVFA 1078
            ..||...|:.:.   :....|..:::|||:.:|.:::.|||::.|.:.|:  ||||||||.:.|.
  Fly   887 LSYLKAKNRQDQ---EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFH 948

Zfish  1079 MASKLIAIEENVICSALKWLVMHKQLPDGSFKEDKPVYHREIMGGIEGQNTDVSLTAFVLIAMQE 1143
            .|:|.|.|::||:.:.|.:|| .:|..||.|||...|.|       ....:.::||:|||:...|
  Fly   949 QAAKYIDIDKNVLVAGLDFLV-SRQSTDGKFKELGMVIH-------NSHGSPLALTSFVLLTFFE 1005

Zfish  1144 GKEICGGAVGSLHESIRKSVAFLKNQLTKLTNPYAAALTSYALANADS------LDKEILMKHST 1202
            .:|.    :......|.::|.|:..::.:...||..|:.:.||:.|.:      |||  |.|.:|
  Fly  1006 NEEY----MPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDK--LDKLAT 1064

Zfish  1203 KGNDGRFWNVPGWHYHS-IEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVF 1266
            :..|.::|........| :|.|:|.:|||::....|.....|.||..:::|:||:.::|.|::..
  Fly  1065 RRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGI 1129

Zfish  1267 QAVAEYRAQVQ------DLKNFDLNVELVVPGRRKTDRWTIQRSNVHLTRSGSV--------DMN 1317
            .|:.:|..|..      |::.:.||.:               :.:|.:|:....        :..
  Fly  1130 MALTKYELQSHASTEAIDIEFWHLNED---------------KKHVRVTKENEFKVQTHQLPENT 1179

Zfish  1318 KDFTVIAKGTGSAILSVLTLYY------ARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTYNFIL 1376
            .:..::|||.|.|.:. ||..|      |||..|.|      .:||.........|..|||..|.
  Fly  1180 NEVKLLAKGQGRAQVQ-LTYRYNVATKEARPSFKLT------TTVKKSHKGRLILGICGTYTPIA 1237

Zfish  1377 DFFYKNKTNDATMTILDIGLPTGF--DIDE-ADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLN 1438
             ...:|||.:  |.::.:.||:|:  ||:. ||::.:|..| |...|.|..:|       .||..
  Fly  1238 -ASERNKTTN--MALMQVQLPSGYVCDIEPFADIEAISDVK-RVETKNEDTEV-------HIYFE 1291

Zfish  1439 KVSHKESETLVFRMHKTFNVGLLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLC 1500
            |:|..:.:.|......|..|..|:|:.|.:|:||:.:....::||   .|::|..:|.|:.|
  Fly  1292 KLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYH---VDTSLCDICHGNEC 1350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
c3a.2NP_571318.1 A2M_N 128..222 CDD:280081 28/102 (27%)
EMA 388..>469 CDD:280624 13/91 (14%)
A2M_N_2 463..599 CDD:285005 38/155 (25%)
ANATO 674..729 CDD:237984 6/54 (11%)
A2M 768..861 CDD:278630 35/102 (34%)
complement_C3_C4_C5 987..1272 CDD:239226 90/293 (31%)
A2M_comp 1042..1272 CDD:284982 76/238 (32%)
A2M_recep 1387..1482 CDD:284981 27/97 (28%)
NTR_complement_C3 1502..1649 CDD:239638
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 26/85 (31%)
A2M_N_2 411..542 CDD:285005 39/157 (25%)
A2M 634..726 CDD:278630 35/94 (37%)
A2M_2 859..1135 CDD:239227 90/292 (31%)
A2M_comp 910..1135 CDD:284982 76/238 (32%)
A2M_recep 1245..1335 CDD:284981 27/99 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584180
Domainoid 1 1.000 56 1.000 Domainoid score I10957
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.800

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