Protein Alignment c3a.2 and Tep3

DIOPT Version :9

• Sequence 1: NP_571318.1
• Gene: c3a.2 / 30491
• ZFINID: ZDB-GENE-990415-36
• Length: 1651
• Species: Danio rerio
• Sequence 2: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Alignment Length: 1628
• Identity: 381/1628 - (23%)
• Similarity: 664/1628 - (40%)
• Gaps: 328/1628 - (20%)

Zfish    11 VLLSSALL--TLCDPLYVLMAPNLLRVGSSENVFVEAQDYSGEPLRVKISVKNFPAKNVEMMQKT 73
            :|:::.||  |....||.::|||.||..|..:|.|...: :.|....|:.:......:.    ||
  Fly    15 ILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHN-APESATFKVGILGSSYTDF----KT 74

Zfish    74 VTLTGEKYQILTDIEIPDDKNFFSDDEKKQYVYLQAHFPSVTLEKVVMVSFQSGY--LFVQTDKP 136
            |.|.....|:| ..|||..:.       .:|.........|.......:.|:|..  :.|||||.
  Fly    75 VELRPFSTQLL-HFEIPALRT-------DRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKS 131

Zfish   137 IYTPGSNVQYRIFSMTPNLKPLSQPG-ITVDIMNPQGITVASDAIKAEKGVK--SSIYN----IP 194
            ||.||..|.||:..:..||||....| :.|||.:.     ..:.|::.|.::  :|||:    :.
  Fly   132 IYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDS-----GDNIIRSYKDIRLTNSIYSNELRLS 191

Zfish   195 DVTSLGMWKVVTRYTNTPLKTFTAEFEVKEYVLPTFEVKL-TPSSFFYYVGDNKQENDEEDSLTV 258
            |....|.|.:|...::   :..|..||:.:::||.|.|.: ||....|          ::..:..
  Fly   192 DSPRFGTWSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAIY----------KDGKIAA 243

Zfish   259 DIEAKYLFGKKMDGNAFV-VFGVMDGAAKTSIVNSL--QKVPVVNGVGTAELTREMITKTFKNIK 320
            .:.|.|.||:.:.|.|.: ::....|:.: ..||.|  :||..::|....|...|         .
  Fly   244 TVRAHYAFGQPIVGEATLSIYPTFFGSLQ-PFVNDLITRKVVPIDGNAYFEFDIE---------N 298

Zfish   321 DLVGKSIYVSVNLLTESGSEMVEAEKRG-IQIVTSPYTI---HYK----RTSQFFKPGMPLGVSV 377
            :|..|..|....||    ..:||.:..| :|..::..|:   ||:    :...::.||:|...:.
  Fly   299 ELHLKQDYERQYLL----DALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATA 359

Zfish   378 YVTNPDETPAKDVEVEVL-----VDGKGGVSGKTR----DNGIAKVKVNTPGGASTLKITAKTKN 433
            .:...|....:|...::.     |.|...:..:|.    .:|..|:|...|.|          ..
  Fly   360 RIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIG----------DR 414

Zfish   434 TEYTS---EQQAVKTMTAQAYKTKH-DSKNYLHINIESAEFEIGDQMTVNLITGQSSGDRDQD-- 492
            .|:.|   :.|.|.:...: ..:|| .||||:...:      :.|:.|||           |:
  Fly   415 DEFHSIIVDYQGVISEVGK-IPSKHLHSKNYITAKV------LNDRPTVN-----------QEIS 461

Zfish   493 -----------YTYMILSKGQIVLAERFKRQGQTLVTLSLTITKEMVPSFRFVAYYHVGKDEVVS 546
                       :.|.::.:|.|:|:........|..|:....:..|:|....:. |.|...|.|.
  Fly   462 VVVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLLV-YTVIDGEFVY 525

Zfish   547 DSVWVDVKDTCMGKLNVEVKEKKNTYETGNDVNLHITGDPGARVGLVVVDKAVQVLNKNR-LTQS 610
            |...:.:::..:..:.|:...:.   ..|.|:::.|:..|.:.|||::||:....|.... ||..
  Fly   526 DEQVIQLEENLLNAVQVDAPIRA---PPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHK 587

Zfish   611 KVWDVIEKHDTGCT----GGGGKDSMGVFSDAGLIF------ESNTAGGTDTRTVPECPAPLKRK 665
            ::.|.:..::....    |..||:| ||.:.:...:      |||.|...:..|.||
  Fly   588 RLMDALRSYELSDVNTPMGSPGKES-GVITMSNTDYFIEKEAESNPALDREVSTGPE-------- 643

Zfish   666 RRSESLQTITTTLAGQYTEKIR----PCCYDGMRNNRIGYTCERRASYVIDGEECVKAFLHCCKE 726
              .:.|.|:..|..|. ..||.    |   .|.......||              .|.|.|
  Fly   644 --EDKLTTVRKTDIGP-AHKIEVNTLP---PGKGRYAFSYT--------------PKPFWH---- 684

Zfish   727 VKNHKEKETEEEELILARSDEDEEGDYKDYDDITSRTQFPESWLWEEFDLCDKCSKPSKDKV-IY 790
                      ...:.:.|...|                   :||:    |....|...::.: ..
  Fly   685 ----------NPRVHVMRDPAD-------------------TWLF----LNISASSDGRNSIHRR 716

Zfish   791 LKDSITTWQILAISLSPTHGICVAEPE-EIVVFKSFFIDLKVPYSAVRGEQVEIKAIIHNYTPKH 854
            :...:|:|.:.|.:|.|.:|:.::.|. ::..:|.|:|..::|||..|.|.:.|..::||.....
  Fly   717 IPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSD 781

Zfish   855 LKKVRVEFLETA------GVCSAASKKGKY----RTTVNVDKDSSVAVSFVIVPMTLESQHIEVK 909
            | .|.|.|..:|      .:...|:.:.|.    |.::.|...|:.:|||::.|..:....::..
  Fly   782 L-NVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAM 845

Zfish   910 ASISDYEDGVRKTLKVVSEGVLTKF-RTEKLELNPGKKGEKPLVLRSGIPADQVP-GTPVNSYIT 972
            |:.|...|.|.:.|.|...|.:.:. |....|||...:..:.:.:  .:|.:.:| .|.:.  ::
  Fly   846 AASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTI--AVPRNAIPESTRIE--VS 906

Zfish   973 VTGEEISQSIEQAINGSFMG---ELIIQPHGCGEQNMVTMTLPFIATHYLDNTNQWEYVGIDRRK 1034
            ..|:.|         ||.:|   .||:.|.|||||.||......|...||....|.. ..::.|
  Fly   907 AVGDLI---------GSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLT-PEVELR- 960

Zfish  1035 VAINHIKTGYEGQLKFRKQDGSYA---LWIETDSSTWLTAYVAKVFAMASKLIAIEENVICSALK 1096
             |.|::..||:..|.:|.::|:::   |.|:. ||||||||||:....|:....::.||:..||.
  Fly   961 -ATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLRQAAPFTQVDSNVLQKALT 1023

Zfish  1097 WLVMHKQLPDGSFKEDKPVYHREIMGGIEGQNTDVSLTAFVLIAMQEGKEICGGAVGSLHESIRK 1161
            :| ...|..:|.|:|...|:.|   .|.:|    :||||||.:|:.|..::    ......:|.|
  Fly  1024 YL-GSVQSANGGFEERGDVFER---FGDDG----ISLTAFVTLALMENVDL----YPEYRNNINK 1076

Zfish  1162 SVAFLKNQLTKLTNPYAAALTSYALANADSLDKEILMKH---STKGNDG-RFWN--VPGWHYHS- 1219
            ::.|:...|...:|.:|.|:.:|.|:.|:...|...::.   .....|| ::||  .|.....|
  Fly  1077 ALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSP 1141

Zfish  1220 ---------IEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVFQAV---AE- 1271
                     ||.:|||.|||::......|...::||..|::..||:..:|.|::..||:   ||
  Fly  1142 WYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAER 1206

Zfish  1272 YRAQVQDLK---NFDLNVELVVPGRRKTDRWTIQRSNVHLTRSGSVDMN-KDFTVIAKGTGSAIL 1332
            :.:|..:|:   ::....|.::         .:...|....::..:..| |:.:|.|.|.|.|:.
  Fly  1207 FSSQGNNLQIGFHYGEGAETII---------NVNAENSLALQTVELPNNLKNLSVSATGRGMALA 1262

Zfish  1333 SVLTLYYARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTY-------NFILDFFYKNKTNDATMT 1390
            .|...|       .|:.|.......||  |.....::..|       :|: ....:|:.. :.|.
  Fly  1263 QVSYTY-------NTNVTSAWPRFVLD--PTVNRNSHADYLHLSACASFV-SVVGENEQR-SNMA 1316

Zfish  1391 ILDIGLPTGFDIDEADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLNKVSHKE-SETLVFRMHK 1454
            ::::.||:||.:|...|..|.:.     ::.:|.:..:....::||.:.:..:| ..||  ..:|
  Fly  1317 VMEVHLPSGFVVDRDTLPTLESS-----ERIKKVETQNRNTKVVIYFDYLDRREVCPTL--HAYK 1374

Zfish  1455 TFNVGLLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLC-VCAEENC-SYQKKNQVNE 1517
            |..|...:|.:|.:|:||....|.:::          ||..|.::| :|...|| ...:|.:..|
  Fly  1375 TVKVTKHRPVAVVMYDYYDSARRARQF----------YRAPKSNICDICEHANCGDLCEKAEKRE 1429

Zfish  1518 SDR 1520
            |.|
  Fly  1430 SKR 1432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c3a.2	NP_571318.1	A2M_N	128..222	CDD:280081	31/102 (30%)
		EMA	388..>469	CDD:280624	19/93 (20%)
		A2M_N_2	463..599	CDD:285005	28/148 (19%)
		ANATO	674..729	CDD:237984	11/58 (19%)
		A2M	768..861	CDD:278630	24/94 (26%)
		complement_C3_C4_C5	987..1272	CDD:239226	96/310 (31%)
		A2M_comp	1042..1272	CDD:284982	76/252 (30%)
		A2M_recep	1387..1482	CDD:284981	23/95 (24%)
		NTR_complement_C3	1502..1649	CDD:239638	7/20 (35%)
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	30/98 (31%)
		A2M_N_2	448..573	CDD:285005	27/145 (19%)
		A2M	697..787	CDD:278630	24/94 (26%)
		A2M_2	918..1203	CDD:239227	91/300 (30%)
		A2M_comp	967..1200	CDD:284982	73/245 (30%)
		A2M_recep	1313..1402	CDD:284981	23/105 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584181
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800