Protein Alignment c3a.2 and Tep2

DIOPT Version :9

• Sequence 1: NP_571318.1
• Gene: c3a.2 / 30491
• ZFINID: ZDB-GENE-990415-36
• Length: 1651
• Species: Danio rerio
• Sequence 2: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Alignment Length: 1627
• Identity: 414/1627 - (25%)
• Similarity: 674/1627 - (41%)
• Gaps: 338/1627 - (20%)

Zfish     6 LFLSAVLLSSALLTLCDPLYVLMAPNLLRVGSSENVFVEAQDYSGEPLRVKISVKNFPAKNVEMM 70
            :||:.::|..|||.....:|.::.|..||..|..||.|......| |.::|:|
  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADG-PSQIKVS------------ 55

Zfish    71 QKTVTLTGEKYQILTDIEIPDDKNFFSDDEKKQYVYLQAHFPSVTLEKVVMVSFQSG-------- 127
                 |.|..|.....||:|.   ..:.:.:.:...|.....:::.|.|..|.|::.
  Fly    56 -----LNGPSYNETKQIELPP---MSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADK 112

Zfish   128 --YLFVQTDKPIYTPGSNVQYRIFSMTPNLKP--LSQPGITVDIMNPQG-ITVASDAIKAEKGVK 187
              .:||||||..|.|...||:||..:..|.:|  :.:|...:.|...|. |...|| :|..|||.
  Fly   113 KPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSD-VKLTKGVF 176

Zfish   188 SSIYNIPDVTSLGMWKVVTRYTNTPLKTFTAEFEVKEYVLPTFEVKL-TPSSFFYYVGDNKQEND 251
            |....:.:...||.||:.........:  |..|||.:||||.|||.: ||.:  ..:.|.
  Fly   177 SGELQLSEQPVLGTWKISVSVDGDNRE--TKSFEVDKYVLPKFEVIVDTPKA--VVIADK----- 232

Zfish   252 EEDSLTVDIEAKYLFGKKMDGNAFV-------VFGVMDGAAKTSIVNSLQKVPVVNGVGTAELTR 309
               .:...|.|||.:||.:.|.|.|       .||.::...     |..:|...|:|.|..|.
  Fly   233 ---VIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLNANG-----NKQEKTIDVDGKGHVEF-- 287

Zfish   310 EMITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKRTS-------QFF 367
                    :|.....:..|:....|....:|.:...|   |..|:...:|.:|.|       :.|
  Fly   288 --------DIIHWAQRGQYLPPIKLFAVVTEELTGNK---QNATATVVLHQQRYSIEPYERPEHF 341

Zfish   368 KPGMPLGVSVYVTNPDETP----AKDVEVEVLVDGKGGV----------SGKTR--------DNG 410
            :........|.|.|.|.:|    ||:|::        |.          |.|||        :||
  Fly   342 EANKSFIYQVVVKNVDGSPVTNSAKNVKI--------GFDKSYSYFHEPSPKTRINFEAPVNENG 398

Zfish   411 IAKVKVNTPGGAST-LKITAKTKNTEYTSEQQAVKTMTAQAYKTKHDSKNYLHINIESAEFEIGD 474
            ||...|..|...|. .:|.|....:|.|       ..:...::....|:..|.|.:.:.:..:|:
  Fly   399 IATFNVRLPDSDSRYYRIFASFDGSENT-------IGSISKFEPTPMSREPLKIQVNTKKPRLGE 456

Zfish   475 QMTVNLITGQSSGDRDQDY-TYMILSKGQIVLAERFK-RQGQTLVTLSLTITKEMVPSFRFVAYY 537
            |::.::::.:     |..| .|.|:::|.::|::... ..||...|:..|.|..|||......||
  Fly   457 QVSFDVVSIE-----DLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYY 516

Zfish   538 HVGKDEVVSDSVWVDVKDTCMGKLNVEVKEKKNTYETGNDVNLHITGDPGARVGLVVVDKAVQVL 602
            .|..|....:.. :|.:......::|.........|   :|.|.|..|..:.|||:.||::|.:|
  Fly   517 VVNNDLQFEEKT-IDFEKEFSNSIDVSAPTNAKPSE---EVKLRIKTDADSFVGLLGVDQSVLLL 577

Zfish   603 NK-NRLTQSKVWDVIEKHDTGC--TGGGGKDSMGVFSDAGLIFESNTAGGTDTRTVPECPAPLKR 664
            .. |.|:|..:::.:..:.|..  ..|.|:            :...|:|
  Fly   578 KSGNDLSQDDIFNSLNIYQTSTPWMNGYGR------------YPGQTSG---------------- 614

Zfish   665 KRRSESLQTITTTLAGQYTEKIRPC----CYDGMRNNRIGYTCERRASYVI----DGEECVKAFL 721
                  |.|:|.   ..|.....|.    .::|.|:..|     .|..|.:    |..:.: :||
  Fly   615 ------LVTLTN---ANYPYNTGPLVMSYVFEGSRHPWI-----TRPRYRVGIRGDSGDRI-SFL 664

Zfish   722 HCCKEVKNHKE---KETEEEELILARSDEDEEGDYKDYDDITSRTQFPESWLW-----EEFDLCD 778
            ......:|.||   |:|.:.                    .|.|.:|||:|.:     |||.|..
  Fly   665 SQSLNDRNLKEILLKQTPQR--------------------TTIRKEFPETWFFENVGEEEFTLTK 709

Zfish   779 KCSKPSKDKVIYLKDSITTWQILAISLSPTHGICVAE-PEEIVVFKSFFIDLKVPYSAVRGEQVE 842
            |           :.|:||:|.:...||:||.||.:.: |.:|.||:.||:...:|||..|||.:.
  Fly   710 K-----------IPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIA 763

Zfish   843 IKAIIHNYTPKHL--------KKVRVEFLE-TAGVCSAASKKGKYRTTVNVDKDSSVAVSFVIVP 898
            |..:|.||..|.|        .....||.| |..|...|..:.:....|.:..:|..:|||:|.|
  Fly   764 IPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRP 828

Zfish   899 MTLESQHIEVKASISDYEDGVRKTLKVVSEGVLTKFRTEKLELNPGKKGEKPLVLRSGIPADQVP 963
            ..:....:::.|:.:...|.:.:.|||..||| |.|....:.:|...:.|....|.:.||.:.||
  Fly   829 KNVGFTTLKITATSALAGDAIHQKLKVEPEGV-TLFENRAVFINLKDQPEMSQSLDADIPNEVVP 892

Zfish   964 GTPVNSYITVTGEEISQSIEQAINGSFMG-------ELIIQPHGCGEQNMVTMTLPFIATHYLDN 1021
            .              |:.||.::.|..:|       .|:..|:||||||||......:...||:.
  Fly   893 Q--------------SEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEV 943

Zfish  1022 TNQWEYVGIDRRKVAINHIKTGYEGQLKFRKQDGSYALWIETDS--STWLTAYVAKVFAMASKLI 1084
            |.: :...::.:  |...::.||:.:|.::..||||:.:.::|:  ||||||||.:.|..|....
  Fly   944 TGR-KLPSVESK--ARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYT 1005

Zfish  1085 AIEENVICSALKWLVMHKQLPDGSFKEDKPVYHREIMGGIEGQNTDVSLTAFVLIAMQEGKEICG 1149
            .|:..||.:.|.:|| .||...|.|.|...::..      ..|| .::||:|||:|..|..|:
  Fly  1006 DIDPKVITAGLDFLV-SKQKESGEFPEVGKLFDN------ANQN-PLALTSFVLLAFFENHEL-- 1060

Zfish  1150 GAVGSLHESIRKSVAFLKNQLTKLTNPYAAALTSYA--LANADSLDKEILMKHST--KGNDGRFW 1210
              :.....:|:|:|.::..:..|..:.|:.|:.:.|  ||.....:|.|....|.  |.||..:|
  Fly  1061 --IPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWW 1123

Zfish  1211 N-----------VPGWHYHS--IEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVT 1262
            :           |..|...|  :|.|:|.:|||::....:.|...:.||..|::|:||:.:||.|
  Fly  1124 SKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDT 1188

Zfish  1263 IMVFQAVAEYRAQVQDLKNFDLNVELVVPGRRK-TDRWTIQRSNVHLTRSGSVDMNK-----DFT 1321
            ::..||:.:: |......:..:::|....|..| |.:...:.|.|..|.    |:.|     |||
  Fly  1189 VIGLQALTKF-AYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTH----DLPKSTRKVDFT 1248

Zfish  1322 VIAKGTGSAILSVLTLYYARPFEKKTDCTFFDLSVKLDKIPETK--PGTNGTYN--FILDFFYK- 1381
              |||||||::.:...|.....|||               |..|  |....|.|  .|:|...:
  Fly  1249 --AKGTGSAMVQLSYRYNLAEKEKK---------------PSFKVTPTVKDTPNQLLIVDVCAEY 1296

Zfish  1382 ------NKTNDATMTILDIGLPTGFDIDEADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLNKV 1440
                  :|..|:.|.:::|.||:||..|...|     ||.:.:.:.::.:..:...::::|.:.:
  Fly  1297 VPLEDADKDKDSNMAVMEIALPSGFVGDSTSL-----GKIQAVDRVKRVETKNSDSTVVVYFDSL 1356

Zfish  1441 SHKESETLVFRMHKTFNVGLLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLCVCAEE 1505
            :..:...|.....|...|...:||||::|:||..:.:..:||..:   |:|..:|:|..|   .|
  Fly  1357 TPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVK---SSLCDICEGADC---GE 1415

Zfish  1506 NC 1507
            .|
  Fly  1416 GC 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c3a.2	NP_571318.1	A2M_N	128..222	CDD:280081	31/96 (32%)
		EMA	388..>469	CDD:280624	21/99 (21%)
		A2M_N_2	463..599	CDD:285005	33/137 (24%)
		ANATO	674..729	CDD:237984	11/62 (18%)
		A2M	768..861	CDD:278630	34/106 (32%)
		complement_C3_C4_C5	987..1272	CDD:239226	92/310 (30%)
		A2M_comp	1042..1272	CDD:284982	76/248 (31%)
		A2M_recep	1387..1482	CDD:284981	21/94 (22%)
		NTR_complement_C3	1502..1649	CDD:239638	2/6 (33%)
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	31/96 (32%)
		A2M_N_2	445..576	CDD:285005	34/139 (24%)
		A2M	694..782	CDD:278630	34/98 (35%)
		A2M_2	909..1198	CDD:239227	90/303 (30%)
		A2M_comp	961..1199	CDD:284982	76/250 (30%)
		A2M_recep	1308..1398	CDD:284981	21/94 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584182
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800