DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Abl2 and Src42A

DIOPT Version :9

Sequence 1:	XP_038946666.1	Gene:	Abl2 / 304883	RGDID:	1590898	Length:	1188	Species:	Rattus norvegicus
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	187/434 - (43%)
Similarity:	260/434 - (59%)	Gaps:	29/434 - (6%)

- Green bases have known domain annotations that are detailed below.

  Rat   122 GDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAE-- 184
            |..:|:..|..|.|.|.....||:                      |.:.|||...:.|..||
  Fly  1181 GKTSLTTAKKGKSRRLSEFTRGEF----------------------LNEKSWYFRKIKRIEAEKK 1223

  Rat   185 YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDSKVYVTAESRFSTLAELVHHHS 249
            .||....:|:||:|:|||.....|:|:|....|.||||....:...::...:.|.||.|||.|:|
  Fly  1224 LLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYS 1288

  Rat   250 TVADGLVTTLHYPAPKCNKPTVYGVS-PIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 313
            ..:|||...|..|..:..||...|:| ...|:||::||.:....|||.||:|:|:.|:|.. :..
  Fly  1289 KDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNN-TTP 1352

  Rat   314 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSR 378
            ||:||||..||:.::||.||.:||:::|..|:||..|||:|.|.||:||.|.:|:||:||:..:.
  Fly  1353 VAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAG 1417

  Rat   379 E--EVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTA 441
            :  .:....|:.||.||::.|.|||.:|:|||||||||.|||:.::||:|||||:||:..|.|.|
  Fly  1418 KGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEA 1482

  Rat   442 HAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 506
            ..||:|||||||||:..|:.||||||||:||:||.|:.|||..||||:..::|...:|.||||.|
  Fly  1483 RVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQ 1547

  Rat   507 PEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 550
            |..|.|::||:|..||...|..||:| ||.|.....|:.|..|:
  Fly  1548 PPNCEPRLYEIMLECWHKDPMRRPTF-ETLQWKLEDFYTSDQSD 1590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl2	XP_038946666.1	SH3_Abl	111..164	CDD:212784	8/41 (20%)
		SH2_ABL	169..262	CDD:198189	35/94 (37%)
		PTKc_Abl	281..543	CDD:270645	134/263 (51%)
		FABD	1069..1188	CDD:197885
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	34/90 (38%)
		PTKc_Frk_like	1319..1587	CDD:270653	136/269 (51%)
		Pkinase_Tyr	1328..1580	CDD:285015	130/253 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910