DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkp1 and p120ctn

DIOPT Version :9

Sequence 1:	NP_001381145.1	Gene:	Pkp1 / 304822	RGDID:	1307472	Length:	728	Species:	Rattus norvegicus
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	187/694 - (26%)
Similarity:	306/694 - (44%)	Gaps:	108/694 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat   108 TLKREPDNRRFSSYSQMENWSRHYPRGSCAT-------TGAG-----SDICFMQKIKASRSE--- 157
            :|..||.|.: |.:...:|:.:....|..:|       ||.|     :..|...||:.:.::
  Fly    25 SLTHEPANMQ-SQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSI 88

  Rat   158 PDLYCDPRGTLRKGTLGGKGQKTTQNRYSFYS-TC------SGQKAVKKCPVRPPSCTSKQDPV- 214
            ||:...|..|..:....|:.:.|::  |.... ||      :.:..|..|.....:.|..|:..
  Fly    89 PDIENHPLATTVRYVQAGQYEDTSE--YGVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQNTTS 151

  Rat   215 CMPPIS---CNKDMSFGHSRASSKIC-----------------------------------SEDI 241
            .:.|.|   .|.:::...:.|.|: |                                   ||:.
  Fly   152 SIKPFSGRPFNDNINGAEAVADSQ-CRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSEND 215

  Rat   242 ECSGL-----TIPKAVQYLCSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPN 301
            .||.:     .:.:.:.:|.:.....:|..|.|:||.|:.|:..||:...||||..||.||...:
  Fly   216 ICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDS 280

  Rat   302 QNVQQAAAGALRNLVF--RSTTNKLETRRQNGIREAVSLLRRSGSTEIQKQLTGLLWNLSSTDEL 364
            ..:.:.|.||||||.:  ::..||...:...||...|.||.||..||:::.:||:|||:||.::|
  Fly   281 PEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDL 345

  Rat   365 KEELVADALPVLTDRVIIPFSGW---CDGNSNMSREVVDPEVFFNATGCLRNLSSA-DAGRQTMR 425
            |..::.:||..:...||.|.|||   |.|.:..|      .||.||:|.|||:||| :..|..:|
  Fly   346 KRSIIDEALVAVVCSVIKPHSGWDAVCCGETCFS------TVFRNASGVLRNVSSAGEHARGCLR 404

  Rat   426 NYSGLIDSLMAYVQNCVAASRCDDKSVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSS 490
            |...|::.|:..|:..:..:...:|:||||:|||.|||||........|.:..:.|.......||
  Fly   405 NCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSS 469

  Rat   491 ----TGCFSNRGDKMMNNNYDCPLPEEETNP-------------KGSSWLYHSDAIRTYLNLMGK 538
                .|||.....|...||.|. |.|...:.             ||...|:..:.::.||:|:..
  Fly   470 KGENLGCFGTNKKKKEANNSDA-LNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQS 533

  Rat   539 SKKDATLEACAGALQNLTASKGLMSNGMSQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 603
            .....||||.|||:|||:|.....|..:...:. ||||||.:..||:.....||.:.|:.|.|::
  Fly   534 CSNPETLEAAAGAIQNLSACYWQPSIDIRATVR-KEKGLPILVELLRMEVDRVVCAVATALRNLA 597

  Rat   604 RHPVLHRVMGNQVFPEVTRLLTS----HTGNTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSM 664
            .......::|.....::.:.|.|    |..||  |:|.:::...|:..::...|:.::....:..
  Fly   598 IDQRNKELIGKYAMRDLVQKLPSGNVQHDQNT--SDDTITAVLATINEVIKKNPEFSRSLLDSGG 660

  Rat   665 LNNVFNLC-RNSASSPKAAEAARLLLSDMWASKELQSVLRQQGF 707
            ::.:.|:. |....:....:.|..:|..||...||:.|.::.|:
  Fly   661 IDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKNGW 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkp1	NP_001381145.1	None
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	41/113 (36%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	17/35 (49%)
		armadillo repeat	304..339	CDD:293788	14/34 (41%)
		ARM	307..442	CDD:237987	55/140 (39%)
		armadillo repeat	347..392	CDD:293788	18/50 (36%)
		armadillo repeat	515..556	CDD:293788	15/40 (38%)
		ARM	516..643	CDD:237987	38/129 (29%)
		armadillo repeat	562..596	CDD:293788	12/34 (35%)
		armadillo repeat	601..641	CDD:293788	8/41 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940