DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rx2 and hbn

DIOPT Version :9

Sequence 1:	NP_571301.2	Gene:	rx2 / 30473	ZFINID:	ZDB-GENE-990415-237	Length:	327	Species:	Danio rerio
Sequence 2:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	97/282 - (34%)
Similarity:	132/282 - (46%)	Gaps:	62/282 - (21%)

- Green bases have known domain annotations that are detailed below.

Zfish    36 VHSIDVILGFS---KDQDPLLEPIGTH----------------KVDEDQLEEQEKQVNSDPYSHL 81
            |:|||.|||..   |..|...|.:.||                ....:.|..|::|.:|....|.
  Fly    36 VYSIDQILGNQHQIKRSDTPSEVLITHPHHGHPHHIHHLHSSNSNGSNHLSHQQQQQHSQQQHHS 100

Zfish    82 QIPDQTQQQQSVY-----HDTGLFSTDKCDADLGDPRSNVESDSRSPDIPDEDQPKKKHRRNRTT 141
            |   |.||||.:.     .|:...:....|.|..|..|:  |.:...|:.|.::|:|. ||:|||
  Fly   101 Q---QQQQQQQLQVQAKREDSPTNTDGGLDVDNDDELSS--SLNNGHDLSDMERPRKV-RRSRTT 159

Zfish   142 FTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEK---MDTGTMKL 203
            |||:|||:|||||||:.||||::||:|||:::|.|.||||||||||||||::||   .|.....|
  Fly   160 FTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKFMNQDKAGYLL 224

Zfish   204 HDSPIRSFNRPPMAPNVGPMSNSLPLDPWLSSPLSSATPMHSIPGFMGPGQS--LQPTYTAHPGF 266
            .:..:..|                        ||....|.|.:||..|..||  ..|.:..|..|
  Fly   225 PEQGLPEF------------------------PLGIPLPPHGLPGHPGSMQSEFWPPHFALHQHF 265

Zfish   267 LNTSPGMMQNMQP--MPPPPYQ 286
             |.:......:.|  :..|.|:
  Fly   266 -NPAAAAAAGLLPQHLMAPHYK 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rx2	NP_571301.2	Octapeptide motif	37..44		4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..73		6/40 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..139		11/38 (29%)
		Homeobox	139..191	CDD:278475	39/51 (76%)
		OAR	302..316	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	304..317
		Nuclear localization signal. /evidence=ECO:0000255	310..314
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	39/52 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920