DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rx1 and Rx

DIOPT Version :9

Sequence 1:	NP_571300.2	Gene:	rx1 / 30472	ZFINID:	ZDB-GENE-990415-236	Length:	330	Species:	Danio rerio
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	116/305 - (38%)
Similarity:	139/305 - (45%)	Gaps:	93/305 - (30%)

- Green bases have known domain annotations that are detailed below.

Zfish    22 HDMVKAGGAVVGTRVHSIDVILGFNKDQDSLLNPGANAVAHKVGGESLGEPGKLDQRVQPYGHLP 86
            ||...:|........:|.|.....|.|.|||:| |:.|.:..:...:..|.|:
  Fly   488 HDFRNSGNGNPNGNSNSGDHGERLNADSDSLVN-GSCASSEDLNQTNSSEQGE------------ 539

Zfish    87 PLRDGSEQPTFHDADMFSNKCDGDLGDLRKAIESDSKSPDSADGEQPKKKHRRNRTTFTTYQLHE 151
            .:..||:.                               :..|....||||||||||||||||||
  Fly   540 KITSGSDD-------------------------------EGQDDNCAKKKHRRNRTTFTTYQLHE 573

Zfish   152 LERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKIDASTMKLHDSPMLSFNRP 216
            ||||||||||||||||||||||||||||||||||||||||||||||.::..:.|.....|...
  Fly   574 LERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHR-- 636

Zfish   217 SMHPTVGPMNNSLPLDPWLPSPLSSATPVHSIPGFMGPTQGLQTGYPGHSFLSPPQPMAQSM--- 278
                 :|...:.||:||||..||.||     :|||:...   ||.||  |:|:||..:|...
  Fly   637 -----LGCGASGLPVDPWLSPPLLSA-----LPGFLSHP---QTVYP--SYLTPPLSLAPGNLTM 686

Zfish   279 --------------------------QPMAPPPYQCPPPFTDKYP 297
                                      ||..|||   |||....:|
  Fly   687 SSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPP---PPPHGVPHP 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rx1	NP_571300.2	Octapeptide motif	37..44		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..104		4/37 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..142		8/23 (35%)
		Homeobox	141..193	CDD:278475	51/51 (100%)
		OAR	302..318	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
		Nuclear localization signal. /evidence=ECO:0000255	312..316
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	51/51 (100%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5546
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		otm25263
orthoMCL	1	0.900	-	-		OOG6_106944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2565
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850