DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rxrga and usp

DIOPT Version :9

Sequence 1:	NP_571292.3	Gene:	rxrga / 30464	ZFINID:	ZDB-GENE-980526-36	Length:	441	Species:	Danio rerio
Sequence 2:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	209/526 - (39%)
Similarity:	286/526 - (54%)	Gaps:	117/526 - (22%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MDNNDTYLHLSSSLQVAHGHLSSPPSQPPLSSMVSHHHPSIINGLGSPYSVITSSSL-----GSP 60
            |||.|.    .:|.:::|   .....:|.:|.:...::.|......||...:.:.|:     ||.
  Fly     1 MDNCDQ----DASFRLSH---IKEEVKPDISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSN 58

Zfish    61 SASMPTTSNMGYGALNSPQMNSLNSVSSSEDIKPPPGLAGLGS--------YPCGSPGSLSKHIC 117
            |||                  |.|:.:....:...|..|| ||        ||...|.|.|||:|
  Fly    59 SAS------------------SNNNSAGDAQMAQAPNSAG-GSAAAAVQQQYPPNHPLSGSKHLC 104

Zfish   118 AICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYTCRDNKDCQIDKRQRNRCQYCRYQKCLAMGM 182
            :|||||:||||||||||||||||||||:||||||.||:|::|.||||||||||||||||||..||
  Fly   105 SICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGM 169

Zfish   183 KREAVQEERQRGRERSDNEVDSS---------------------------------------SSF 208
            ||||||||||||...:...:.:|                                       :|.
  Fly   170 KREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSV 234

Zfish   209 NEEMPVEKILDAELAVEP----------KTEAYMESSMSNSTNDPVTNICQAADKQLFTLVEWAK 263
            :.:..:|:|::||...|.          :...|  |::.......|:.:||..:||||.:||:|:
  Fly   235 SRDFSIERIIEAEQRAETQCGDRALTFLRVGPY--STVQPDYKGAVSALCQVVNKQLFQMVEYAR 297

Zfish   264 RIPHFSDLPLDDQVILLRAGWNELLIASFSHRS-VTVKDG------------------------- 302
            .:|||:.:|||||||||:|.|.|||||:.:..| |::.||
  Fly   298 MMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQ 362

Zfish   303 -ILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMREMQMDKTELGCLRAIVLFNPDAKGLSNPS 366
             :.|......||:||..|||.:||||:|:||..||:.:.:|:.||.||:||:|:|||.:|:.:.:
  Fly   363 QLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRA 427

Zfish   367 EVEALREKVYASLEGYTKHNYPDQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLM 431
            |:|..||||||.|:.:.:..:|...||||:|||||||||||.|||.:|||.|::..|.|::...:
  Fly   428 EIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFL 492

Zfish   432 EMLEAP 437
            |.||||
  Fly   493 EQLEAP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rxrga	NP_571292.3	Modulating. /evidence=ECO:0000250	1..116		30/127 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..37		3/20 (15%)
		Nuc_recep-AF1	<40..111	CDD:288658	19/83 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..94		8/42 (19%)
		NR_DBD_RXR	115..191	CDD:143514	64/75 (85%)
		Hinge	183..206		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..210		9/60 (15%)
		NR_LBD_RXR_like	211..419	CDD:132741	100/244 (41%)
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	64/75 (85%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	100/244 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3237
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	365	1.000	Inparanoid score	I2124
OMA	1	1.010	-	-		QHG45637
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm25754
orthoMCL	1	0.900	-	-		OOG6_103349
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980